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Id2 inhibitor of DNA binding 2 [ Mus musculus (house mouse) ]

Gene ID: 15902, updated on 13-Mar-2020

Summary

Official Symbol
Id2provided by MGI
Official Full Name
inhibitor of DNA binding 2provided by MGI
Primary source
MGI:MGI:96397
See related
Ensembl:ENSMUSG00000020644
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Idb2; C78922; bHLHb26; AI255428
Expression
Ubiquitous expression in kidney adult (RPKM 169.1), adrenal adult (RPKM 168.8) and 26 other tissues See more
Orthologs

Genomic context

See Id2 in Genome Data Viewer
Location:
12 A1.3; 12 8.57 cM
Exon count:
3
Annotation release Status Assembly Chr Location
108 current GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (25093799..25096092, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 12 NC_000078.5 (25778664..25780957, complement)

Chromosome 12 - NC_000078.6Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 2900060N12 gene Neighboring gene membrane bound O-acyltransferase domain containing 2 Neighboring gene kinase D-interacting substrate 220 Neighboring gene predicted gene, 36236 Neighboring gene predicted gene, 17746 Neighboring gene predicted gene, 36287 Neighboring gene predicted gene, 36496

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
ion channel binding ISO
Inferred from Sequence Orthology
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein dimerization activity IEA
Inferred from Electronic Annotation
more info
 
transcription coactivator activity IDA
Inferred from Direct Assay
more info
PubMed 
transcription regulator activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
Peyer's patch development IGI
Inferred from Genetic Interaction
more info
PubMed 
adipose tissue development IMP
Inferred from Mutant Phenotype
more info
PubMed 
adult locomotory behavior IMP
Inferred from Mutant Phenotype
more info
PubMed 
bundle of His development IMP
Inferred from Mutant Phenotype
more info
PubMed 
cell development IGI
Inferred from Genetic Interaction
more info
PubMed 
cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cell maturation IMP
Inferred from Mutant Phenotype
more info
PubMed 
cell morphogenesis involved in neuron differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
cellular response to lithium ion IDA
Inferred from Direct Assay
more info
PubMed 
cellular senescence IMP
Inferred from Mutant Phenotype
more info
PubMed 
circadian regulation of gene expression IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
circadian regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
circadian rhythm IEP
Inferred from Expression Pattern
more info
PubMed 
embryonic digestive tract morphogenesis IDA
Inferred from Direct Assay
more info
PubMed 
endodermal digestive tract morphogenesis IEP
Inferred from Expression Pattern
more info
PubMed 
entrainment of circadian clock IMP
Inferred from Mutant Phenotype
more info
PubMed 
entrainment of circadian clock by photoperiod IMP
Inferred from Mutant Phenotype
more info
PubMed 
enucleate erythrocyte differentiation IGI
Inferred from Genetic Interaction
more info
PubMed 
epithelial cell differentiation involved in mammary gland alveolus development IMP
Inferred from Mutant Phenotype
more info
PubMed 
heart development IGI
Inferred from Genetic Interaction
more info
PubMed 
leukocyte differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
locomotor rhythm IMP
Inferred from Mutant Phenotype
more info
PubMed 
lymph node development TAS
Traceable Author Statement
more info
PubMed 
mammary gland alveolus development IMP
Inferred from Mutant Phenotype
more info
PubMed 
mammary gland epithelial cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
membranous septum morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
metanephros development IMP
Inferred from Mutant Phenotype
more info
PubMed 
multicellular organism development IEA
Inferred from Electronic Annotation
more info
 
natural killer cell differentiation IGI
Inferred from Genetic Interaction
more info
PubMed 
natural killer cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of B cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of DNA-binding transcription factor activity ISO
Inferred from Sequence Orthology
more info
 
negative regulation of core promoter binding IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
negative regulation of neuron differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of oligodendrocyte differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of osteoblast differentiation IGI
Inferred from Genetic Interaction
more info
PubMed 
negative regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of transcription by RNA polymerase II IGI
Inferred from Genetic Interaction
more info
PubMed 
negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
negative regulation of transcription, DNA-templated IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of transcription, DNA-templated ISO
Inferred from Sequence Orthology
more info
 
neuron fate commitment IMP
Inferred from Mutant Phenotype
more info
PubMed 
olfactory bulb development IMP
Inferred from Mutant Phenotype
more info
PubMed 
oligodendrocyte development IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of astrocyte differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of blood pressure IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of cell cycle ISO
Inferred from Sequence Orthology
more info
 
positive regulation of cell cycle arrest IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of cell proliferation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of erythrocyte differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of fat cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of gene expression IEP
Inferred from Expression Pattern
more info
PubMed 
positive regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of macrophage differentiation IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of smooth muscle cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of transcription, DNA-templated IDA
Inferred from Direct Assay
more info
PubMed 
regulation of G1/S transition of mitotic cell cycle ISO
Inferred from Sequence Orthology
more info
 
regulation of circadian rhythm IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of gene expression IEP
Inferred from Expression Pattern
more info
PubMed 
regulation of lipid metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of neural precursor cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of neuron differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
rhythmic process IEA
Inferred from Electronic Annotation
more info
 
thigmotaxis IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
chromatin ISO
Inferred from Sequence Orthology
more info
 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
colocalizes_with cytoplasm ISO
Inferred from Sequence Orthology
more info
 
cytosol ISO
Inferred from Sequence Orthology
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
nucleus ISO
Inferred from Sequence Orthology
more info
 
protein-containing complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
DNA-binding protein inhibitor ID-2
Names
inhibitor of differentiation 2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_010496.3NP_034626.1  DNA-binding protein inhibitor ID-2

    See identical proteins and their annotated locations for NP_034626.1

    Status: VALIDATED

    Source sequence(s)
    AK135547, BQ044638
    Consensus CDS
    CCDS25846.1
    UniProtKB/Swiss-Prot
    P41136
    UniProtKB/TrEMBL
    Q545T4
    Related
    ENSMUSP00000020974.6, ENSMUST00000020974.6
    Conserved Domains (1) summary
    cd00083
    Location:3879
    HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p6 C57BL/6J

Genomic

  1. NC_000078.6 Reference GRCm38.p6 C57BL/6J

    Range
    25093799..25096092 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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