Format

Send to:

Choose Destination

ID2 inhibitor of DNA binding 2 [ Homo sapiens (human) ]

Gene ID: 3398, updated on 22-Jun-2021

Summary

Official Symbol
ID2provided by HGNC
Official Full Name
inhibitor of DNA binding 2provided by HGNC
Primary source
HGNC:HGNC:5361
See related
Ensembl:ENSG00000115738 MIM:600386
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GIG8; ID2A; ID2H; bHLHb26
Summary
The protein encoded by this gene belongs to the inhibitor of DNA binding family, members of which are transcriptional regulators that contain a helix-loop-helix (HLH) domain but not a basic domain. Members of the inhibitor of DNA binding family inhibit the functions of basic helix-loop-helix transcription factors in a dominant-negative manner by suppressing their heterodimerization partners through the HLH domains. This protein may play a role in negatively regulating cell differentiation. A pseudogene of this gene is located on chromosome 3. [provided by RefSeq, Aug 2011]
Expression
Ubiquitous expression in liver (RPKM 128.2), bone marrow (RPKM 111.2) and 24 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See ID2 in Genome Data Viewer
Location:
2p25.1
Exon count:
3
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 2 NC_000002.12 (8682056..8684461)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (8822186..8824591)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105373411 Neighboring gene VISTA enhancer hs1527 Neighboring gene ID2 antisense RNA 1 Neighboring gene uncharacterized LOC107985849 Neighboring gene kinase D interacting substrate 220 Neighboring gene ADP ribosylation factor like GTPase 1 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
A genome-wide association meta-analysis of self-reported allergy identifies shared and allergy-specific susceptibility loci.
GeneReviews: Not available
A genome-wide association study of plasma total IgE concentrations in the Framingham Heart Study.
GeneReviews: Not available

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC26389

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables RNA polymerase II-specific DNA-binding transcription factor binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein dimerization activity IEA
Inferred from Electronic Annotation
more info
 
enables transcription regulator activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables transcription regulator inhibitor activity ISS
Inferred from Sequence or Structural Similarity
more info
 
enables transcription regulator inhibitor activity TAS
Traceable Author Statement
more info
PubMed 
enables transmembrane transporter binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within bundle of His development ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in bundle of His development NAS
Non-traceable Author Statement
more info
PubMed 
involved_in cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in cellular senescence ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in circadian regulation of gene expression IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in circadian regulation of gene expression ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in circadian rhythm ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in embryonic digestive tract morphogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in endodermal digestive tract morphogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in entrainment of circadian clock by photoperiod ISS
Inferred from Sequence or Structural Similarity
more info
 
acts_upstream_of_or_within enucleate erythrocyte differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in epithelial cell differentiation involved in mammary gland alveolus development ISS
Inferred from Sequence or Structural Similarity
more info
 
acts_upstream_of_or_within heart development ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in locomotor rhythm ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in mammary gland alveolus development ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in mammary gland epithelial cell proliferation ISS
Inferred from Sequence or Structural Similarity
more info
 
acts_upstream_of_or_within negative regulation of B cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of DNA-binding transcription factor activity IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of gene expression ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of muscle cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in negative regulation of transcription by RNA polymerase II ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of transcription, DNA-templated IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of neuron fate commitment ISS
Inferred from Sequence or Structural Similarity
more info
 
acts_upstream_of_or_within olfactory bulb development ISS
Inferred from Sequence or Structural Similarity
more info
 
acts_upstream_of_or_within positive regulation of astrocyte differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of blood pressure ISS
Inferred from Sequence or Structural Similarity
more info
 
acts_upstream_of_or_within positive regulation of fat cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of gene expression ISS
Inferred from Sequence or Structural Similarity
more info
 
acts_upstream_of_or_within positive regulation of macrophage differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of smooth muscle cell proliferation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of transcription involved in G1/S transition of mitotic cell cycle IC
Inferred by Curator
more info
PubMed 
involved_in positive regulation of transcription, DNA-templated ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in regulation of G1/S transition of mitotic cell cycle IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of cell cycle ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in regulation of circadian rhythm ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in regulation of lipid metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
 
acts_upstream_of_negative_effect regulation of neural precursor cell proliferation ISS
Inferred from Sequence or Structural Similarity
more info
 
acts_upstream_of_negative_effect regulation of neuron differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
colocalizes_with cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
PubMed 
located_in euchromatin ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
part_of protein-containing complex ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
DNA-binding protein inhibitor ID-2
Names
DNA-binding protein inhibitor ID2
cell growth-inhibiting gene 8
class B basic helix-loop-helix protein 26
helix-loop-helix protein ID2
inhibitor of DNA binding 2, HLH protein
inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
inhibitor of differentiation 2

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_002166.5NP_002157.2  DNA-binding protein inhibitor ID-2

    See identical proteins and their annotated locations for NP_002157.2

    Status: REVIEWED

    Source sequence(s)
    AC011747
    Consensus CDS
    CCDS1659.1
    UniProtKB/Swiss-Prot
    Q02363
    UniProtKB/TrEMBL
    Q53T66
    Related
    ENSP00000379585.1, ENST00000396290.2
    Conserved Domains (1) summary
    cd19692
    Location:1883
    bHLH_dnHLH_ID2; basic helix-loop-helix (bHLH) domain found in DNA-binding protein inhibitor ID2 and similar proteins

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p13 Primary Assembly

    Range
    8682056..8684461
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Support Center