ID2 inhibitor of DNA binding 2 [Homo sapiens (human)] - Gene

Summary

Official Symbol: ID2provided by HGNC
Official Full Name: inhibitor of DNA binding 2provided by HGNC
Primary source: HGNC:HGNC:5361
See related: Ensembl:ENSG00000115738 MIM:600386; AllianceGenome:HGNC:5361
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: GIG8; ID2A; ID2H; bHLHb26
Summary: The protein encoded by this gene belongs to the inhibitor of DNA binding family, members of which are transcriptional regulators that contain a helix-loop-helix (HLH) domain but not a basic domain. Members of the inhibitor of DNA binding family inhibit the functions of basic helix-loop-helix transcription factors in a dominant-negative manner by suppressing their heterodimerization partners through the HLH domains. This protein may play a role in negatively regulating cell differentiation. A pseudogene of this gene is located on chromosome 3. [provided by RefSeq, Aug 2011]
Expression: Ubiquitous expression in liver (RPKM 128.2), bone marrow (RPKM 111.2) and 24 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 2p25.1

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
110	current	GRCh38.p14 (GCF_000001405.40)	2	NC_000002.12 (8682056..8684461)
110	current	T2T-CHM13v2.0 (GCF_009914755.1)	2	NC_060926.1 (8705779..8708184)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	2	NC_000002.11 (8822186..8824591)

Chromosome 2 - NC_000002.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

ID proteins promote the survival and primed-to-naive transition of human embryonic stem cells through TCF3-mediated transcription.
Title: ID proteins promote the survival and primed-to-naive transition of human embryonic stem cells through TCF3-mediated transcription.
KSHV RTA Induces Degradation of the Host Transcription Repressor ID2 To Promote the Viral Lytic Cycle.
Title: KSHV RTA Induces Degradation of the Host Transcription Repressor ID2 To Promote the Viral Lytic Cycle.
GDF-11 promotes human trophoblast cell invasion by increasing ID2-mediated MMP2 expression.
Title: GDF-11 promotes human trophoblast cell invasion by increasing ID2-mediated MMP2 expression.
Temporal Expression of Transcription Factor ID2 Improves Natural Killer Cell Differentiation from Human Pluripotent Stem Cells.
Title: Temporal Expression of Transcription Factor <i>ID2</i> Improves Natural Killer Cell Differentiation from Human Pluripotent Stem Cells.
[Increased expression of inhibitor of differentiation 2 (Id2) in CD4(+)T cells in joint synovial fluid of patients with rheumatoid arthritis].
Title: [Increased expression of inhibitor of differentiation 2 (Id2) in CD4<sup>+</sup>T cells in joint synovial fluid of patients with rheumatoid arthritis].
Inhibitor of DNA binding 2 (ID2) regulates the expression of developmental genes and tumorigenesis in ewing sarcoma.
Title: Inhibitor of DNA binding 2 (ID2) regulates the expression of developmental genes and tumorigenesis in ewing sarcoma.
LncRNA IPW inhibits growth of ductal carcinoma in situ by downregulating ID2 through miR-29c.
Title: LncRNA IPW inhibits growth of ductal carcinoma in situ by downregulating ID2 through miR-29c.
ASCL1 phosphorylation and ID2 upregulation are roadblocks to glioblastoma stem cell differentiation.
Title: ASCL1 phosphorylation and ID2 upregulation are roadblocks to glioblastoma stem cell differentiation.
USP1 Promotes GC Metastasis via Stabilizing ID2.
Title: USP1 Promotes GC Metastasis via Stabilizing ID2.
Inhibitor of Differentiation-2 Protein Ameliorates DSS-Induced Ulcerative Colitis by Inhibiting NF-kappaB Activation in Neutrophils.
Title: Inhibitor of Differentiation-2 Protein Ameliorates DSS-Induced Ulcerative Colitis by Inhibiting NF-κB Activation in Neutrophils.

Submit: New GeneRIF Correction See all GeneRIFs (110)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
A genome-wide association meta-analysis of self-reported allergy identifies shared and allergy-specific susceptibility loci. EBI GWAS Catalog EBI GWAS CatalogPubMed
A genome-wide association study of plasma total IgE concentrations in the Framingham Heart Study. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH25021 (e-PCR)
- UniSTS:92939

D2S208E (e-PCR)
- UniSTS:147792

D3S4003 (e-PCR)
- UniSTS:67215

RH67912 (e-PCR)
- UniSTS:39848

RH11441 (e-PCR)
- UniSTS:87477

ID2_2310 (e-PCR)
- UniSTS:280771

Homology

Homologs of the ID2 gene: The ID2 gene is conserved in chimpanzee, Rhesus monkey, cow, mouse, rat, chicken, zebrafish, and frog.
Orthologs from Annotation Pipeline: 307 organisms have orthologs with human gene ID2
Orthologs

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables RNA polymerase II-specific DNA-binding transcription factor binding	ISS Inferred from Sequence or Structural Similarity more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein dimerization activity	IEA Inferred from Electronic Annotation more info
enables transcription regulator activity	IBA Inferred from Biological aspect of Ancestor more info	PubMed
enables transcription regulator inhibitor activity	ISS Inferred from Sequence or Structural Similarity more info
enables transcription regulator inhibitor activity	TAS Traceable Author Statement more info	PubMed
enables transmembrane transporter binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within bundle of His development	ISS Inferred from Sequence or Structural Similarity more info
involved_in cell differentiation	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in cellular senescence	ISS Inferred from Sequence or Structural Similarity more info
involved_in circadian regulation of gene expression	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in circadian regulation of gene expression	ISS Inferred from Sequence or Structural Similarity more info
involved_in circadian rhythm	ISS Inferred from Sequence or Structural Similarity more info
involved_in embryonic digestive tract morphogenesis	ISS Inferred from Sequence or Structural Similarity more info
involved_in endodermal digestive tract morphogenesis	ISS Inferred from Sequence or Structural Similarity more info
involved_in entrainment of circadian clock by photoperiod	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within enucleate erythrocyte differentiation	ISS Inferred from Sequence or Structural Similarity more info
involved_in epithelial cell differentiation involved in mammary gland alveolus development	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within heart development	ISS Inferred from Sequence or Structural Similarity more info
involved_in locomotor rhythm	ISS Inferred from Sequence or Structural Similarity more info
involved_in mammary gland alveolus development	ISS Inferred from Sequence or Structural Similarity more info
involved_in mammary gland epithelial cell proliferation	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within negative regulation of B cell differentiation	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of DNA-binding transcription factor activity	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of DNA-templated transcription	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of gene expression	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of muscle cell differentiation	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of neuron fate commitment	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within olfactory bulb development	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of DNA-templated transcription	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within positive regulation of astrocyte differentiation	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of blood pressure	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within positive regulation of fat cell differentiation	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of gene expression	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within positive regulation of macrophage differentiation	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of smooth muscle cell proliferation	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of transcription involved in G1/S transition of mitotic cell cycle	IC Inferred by Curator more info	PubMed
involved_in regulation of G1/S transition of mitotic cell cycle	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of circadian rhythm	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of lipid metabolic process	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_negative_effect regulation of neural precursor cell proliferation	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_negative_effect regulation of neuron differentiation	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
colocalizes_with cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
located_in euchromatin	ISS Inferred from Sequence or Structural Similarity more info
located_in nucleoplasm	TAS Traceable Author Statement more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info	PubMed
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
part_of protein-containing complex	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: DNA-binding protein inhibitor ID-2

Names: DNA-binding protein inhibitor ID2; cell growth-inhibiting gene 8; class B basic helix-loop-helix protein 26; helix-loop-helix protein ID2; inhibitor of DNA binding 2, HLH protein; inhibitor of DNA binding 2, dominant negative helix-loop-helix protein; inhibitor of differentiation 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_002166.5 → NP_002157.2 DNA-binding protein inhibitor ID-2

See identical proteins and their annotated locations for NP_002157.2

Status: REVIEWED

Source sequence(s)

AC011747

Consensus CDS

CCDS1659.1

UniProtKB/Swiss-Prot

Q02363

UniProtKB/TrEMBL

D6W4Y7, Q53T66

Related

ENSP00000379585.1, ENST00000396290.2

Conserved Domains (1) summary

cd19692
Location:18 → 83

bHLH_dnHLH_ID2; basic helix-loop-helix (bHLH) domain found in DNA-binding protein inhibitor ID2 and similar proteins