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Icam2 intercellular adhesion molecule 2 [ Mus musculus (house mouse) ]

Gene ID: 15896, updated on 21-Apr-2024

Summary

Official Symbol
Icam2provided by MGI
Official Full Name
intercellular adhesion molecule 2provided by MGI
Primary source
MGI:MGI:96394
See related
Ensembl:ENSMUSG00000001029 AllianceGenome:MGI:96394
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
CD102; Ly-60; Icam-2
Summary
Predicted to enable integrin binding activity. Predicted to be involved in cell adhesion. Located in microvillus; plasma membrane; and uropod. Is integral component of plasma membrane. Is expressed in central nervous system; extraembryonic component; female reproductive system; retina; and vascular element. Orthologous to human ICAM2 (intercellular adhesion molecule 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in lung adult (RPKM 101.8), thymus adult (RPKM 40.1) and 12 other tissues See more
Orthologs
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Genomic context

Location:
11 E1; 11 69.09 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (106268482..106278948, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (106377656..106388139, complement)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_30919 Neighboring gene STARR-positive B cell enhancer ABC_E7081 Neighboring gene CD79B antigen Neighboring gene sodium channel, voltage-gated, type IV, alpha Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:106235839-106236093 Neighboring gene proline rich 29 Neighboring gene STARR-positive B cell enhancer ABC_E10722 Neighboring gene endoplasmic reticulum to nucleus signalling 1 Neighboring gene STARR-positive B cell enhancer ABC_E9845 Neighboring gene STARR-positive B cell enhancer ABC_E10723 Neighboring gene STARR-positive B cell enhancer ABC_E7082 Neighboring gene STARR-seq mESC enhancer starr_30924 Neighboring gene STARR-positive B cell enhancer mm9_chr11:106361934-106362235 Neighboring gene small nucleolar RNA, C/D box 104 Neighboring gene predicted gene, 36220

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables integrin binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables integrin binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in cell adhesion IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in cell-cell adhesion IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in cell periphery IDA
Inferred from Direct Assay
more info
PubMed 
located_in cell projection IEA
Inferred from Electronic Annotation
more info
 
located_in cleavage furrow ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in microvillus IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in uropod IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
intercellular adhesion molecule 2
Names
lymphocyte function-associated AG-1 counter-receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_010494.2NP_034624.1  intercellular adhesion molecule 2 precursor

    See identical proteins and their annotated locations for NP_034624.1

    Status: VALIDATED

    Source sequence(s)
    AL604045, X65493
    Consensus CDS
    CCDS25555.1
    UniProtKB/Swiss-Prot
    P35330, Q9D8Q4
    Related
    ENSMUSP00000001055.9, ENSMUST00000001055.15
    Conserved Domains (2) summary
    pfam03921
    Location:23114
    ICAM_N; Intercellular adhesion molecule (ICAM), N-terminal domain
    cl11960
    Location:112200
    Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    106268482..106278948 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011248762.4XP_011247064.1  intercellular adhesion molecule 2 isoform X1

    See identical proteins and their annotated locations for XP_011247064.1

    Conserved Domains (2) summary
    pfam03921
    Location:59150
    ICAM_N; Intercellular adhesion molecule (ICAM), N-terminal domain
    cl11960
    Location:148236
    Ig; Immunoglobulin domain
  2. XM_006532303.3XP_006532366.1  intercellular adhesion molecule 2 isoform X2

    See identical proteins and their annotated locations for XP_006532366.1

    UniProtKB/Swiss-Prot
    P35330, Q9D8Q4
    Conserved Domains (2) summary
    pfam03921
    Location:23114
    ICAM_N; Intercellular adhesion molecule (ICAM), N-terminal domain
    cl11960
    Location:112200
    Ig; Immunoglobulin domain
  3. XM_011248763.4XP_011247065.1  intercellular adhesion molecule 2 isoform X1

    See identical proteins and their annotated locations for XP_011247065.1

    Conserved Domains (2) summary
    pfam03921
    Location:59150
    ICAM_N; Intercellular adhesion molecule (ICAM), N-terminal domain
    cl11960
    Location:148236
    Ig; Immunoglobulin domain
  4. XM_030245595.2XP_030101455.1  intercellular adhesion molecule 2 isoform X2

    UniProtKB/Swiss-Prot
    P35330, Q9D8Q4
    Conserved Domains (2) summary
    pfam03921
    Location:23114
    ICAM_N; Intercellular adhesion molecule (ICAM), N-terminal domain
    cl11960
    Location:112200
    Ig; Immunoglobulin domain
  5. XM_011248761.4XP_011247063.1  intercellular adhesion molecule 2 isoform X1

    See identical proteins and their annotated locations for XP_011247063.1

    Conserved Domains (2) summary
    pfam03921
    Location:59150
    ICAM_N; Intercellular adhesion molecule (ICAM), N-terminal domain
    cl11960
    Location:148236
    Ig; Immunoglobulin domain