Format

Send to:

Choose Destination

ICAM2 intercellular adhesion molecule 2 [ Homo sapiens (human) ]

Gene ID: 3384, updated on 23-Dec-2018

Summary

Official Symbol
ICAM2provided by HGNC
Official Full Name
intercellular adhesion molecule 2provided by HGNC
Primary source
HGNC:HGNC:5345
See related
Ensembl:ENSG00000108622 MIM:146630
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CD102
Summary
The protein encoded by this gene is a member of the intercellular adhesion molecule (ICAM) family. All ICAM proteins are type I transmembrane glycoproteins, contain 2-9 immunoglobulin-like C2-type domains, and bind to the leukocyte adhesion LFA-1 protein. This protein may play a role in lymphocyte recirculation by blocking LFA-1-dependent cell adhesion. It mediates adhesive interactions important for antigen-specific immune response, NK-cell mediated clearance, lymphocyte recirculation, and other cellular interactions important for immune response and surveillance. Several transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
Expression
Broad expression in spleen (RPKM 62.3), placenta (RPKM 26.4) and 17 other tissues See more
Orthologs

Genomic context

See ICAM2 in Genome Data Viewer
Location:
17q23.3
Exon count:
6
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 17 NC_000017.11 (64002595..64020634, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (62079955..62097994, complement)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene sodium voltage-gated channel alpha subunit 4 Neighboring gene uncharacterized LOC105371858 Neighboring gene PRR29 antisense RNA 1 Neighboring gene proline rich 29 Neighboring gene endoplasmic reticulum to nucleus signaling 1 Neighboring gene small nucleolar RNA, C/D box 104 Neighboring gene small nucleolar RNA host gene 25

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

HIV-1 interactions

Replication interactions

Interaction Pubs
HIV-1 infection (VSV-G pseudotyped) of CEMT4 T cells downregulates plasma membrane expression of ICAM2 PubMed

Protein interactions

Protein Gene Interaction Pubs
Nef nef Both HIV-1 Nef and Vpu downregulate the cell surface expression of intercellular adhesion molecule 2 (ICAM2, CD102) PubMed
Vpu vpu Both HIV-1 Nef and Vpu downregulate the cell surface expression of intercellular adhesion molecule 2 (ICAM2, CD102) PubMed
vpu HIV-1 Vpu is identified to have a physical interaction with intercellular adhesion molecule 2 (ICAM2) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

  • Adaptive Immune System, organism-specific biosystem (from REACTOME)
    Adaptive Immune System, organism-specific biosystemAdaptive immunity refers to antigen-specific immune response efficiently involved in clearing the pathogens. The adaptive immune system is comprised of B and T lymphocytes that express receptors with...
  • C-type lectin receptors (CLRs), organism-specific biosystem (from REACTOME)
    C-type lectin receptors (CLRs), organism-specific biosystemPathogen recognition is central to the induction of T cell differentiation. Groups of pathogens share similar structures known as pathogen-associated molecular patterns (PAMPs), which are recognised ...
  • CD209 (DC-SIGN) signaling, organism-specific biosystem (from REACTOME)
    CD209 (DC-SIGN) signaling, organism-specific biosystemCD209 (also called as DC-SIGN (DC-specific intracellular adhesion molecule-3-grabbing non-integrin)) is a type II transmembrane C-type lectin receptor preferentially expressed on dendritic cells (DCs...
  • Cell adhesion molecules (CAMs), organism-specific biosystem (from KEGG)
    Cell adhesion molecules (CAMs), organism-specific biosystemCell adhesion molecules are (glyco)proteins expressed on the cell surface and play a critical role in a wide array of biologic processes that include hemostasis, the immune response, inflammation, em...
  • Cell adhesion molecules (CAMs), conserved biosystem (from KEGG)
    Cell adhesion molecules (CAMs), conserved biosystemCell adhesion molecules are (glyco)proteins expressed on the cell surface and play a critical role in a wide array of biologic processes that include hemostasis, the immune response, inflammation, em...
  • Extracellular matrix organization, organism-specific biosystem (from REACTOME)
    Extracellular matrix organization, organism-specific biosystemThe extracellular matrix is a component of all mammalian tissues, a network consisting largely of the fibrous proteins collagen, elastin and associated-microfibrils, fibronectin and laminins embedded...
  • Immune System, organism-specific biosystem (from REACTOME)
    Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
  • Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell, organism-specific biosystem (from REACTOME)
    Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell, organism-specific biosystemA number of receptors and cell adhesion molecules play a key role in modifying the response of cells of lymphoid origin (such as B-, T- and NK cells) to self and tumor antigens, as well as to pathoge...
  • Innate Immune System, organism-specific biosystem (from REACTOME)
    Innate Immune System, organism-specific biosystemInnate immunity encompases the nonspecific part of immunity tha are part of an individual's natural biologic makeup
  • Integrin cell surface interactions, organism-specific biosystem (from REACTOME)
    Integrin cell surface interactions, organism-specific biosystemThe extracellular matrix (ECM) is a network of macro-molecules that underlies all epithelia and endothelia and that surrounds all connective tissue cells. This matrix provides the mechanical strength...
  • Natural killer cell mediated cytotoxicity, organism-specific biosystem (from KEGG)
    Natural killer cell mediated cytotoxicity, organism-specific biosystemNatural killer (NK) cells are lymphocytes of the innate immune system that are involved in early defenses against both allogeneic (nonself) cells and autologous cells undergoing various forms of stre...
  • Natural killer cell mediated cytotoxicity, conserved biosystem (from KEGG)
    Natural killer cell mediated cytotoxicity, conserved biosystemNatural killer (NK) cells are lymphocytes of the innate immune system that are involved in early defenses against both allogeneic (nonself) cells and autologous cells undergoing various forms of stre...
  • amb2 Integrin signaling, organism-specific biosystem (from Pathway Interaction Database)
    amb2 Integrin signaling, organism-specific biosystem
    amb2 Integrin signaling

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
integrin binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
integrin binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
cell adhesion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cell-cell adhesion IEA
Inferred from Electronic Annotation
more info
 
extracellular matrix organization TAS
Traceable Author Statement
more info
 
regulation of immune response TAS
Traceable Author Statement
more info
 
stimulatory C-type lectin receptor signaling pathway TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
cleavage furrow IDA
Inferred from Direct Assay
more info
PubMed 
integral component of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
membrane HDA PubMed 
microvillus ISS
Inferred from Sequence or Structural Similarity
more info
 
plasma membrane TAS
Traceable Author Statement
more info
 
uropod IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
intercellular adhesion molecule 2
Names
ICAM-2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_000873.3NP_000864.2  intercellular adhesion molecule 2 precursor

    See identical proteins and their annotated locations for NP_000864.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR compared to variant 1. All 5 variants encode the same protein.
    Source sequence(s)
    AK223219, BM695682
    Consensus CDS
    CCDS11657.1
    UniProtKB/Swiss-Prot
    P13598
    UniProtKB/TrEMBL
    Q6FHE2
    Related
    ENSP00000392634.2, ENST00000449662.6
    Conserved Domains (2) summary
    cd05755
    Location:112211
    Ig2_ICAM-1_like; Second immunoglobulin (Ig)-like domain of intercellular cell adhesion molecule-1 (ICAM-1, CD54) and similar proteins
    pfam03921
    Location:24109
    ICAM_N; Intercellular adhesion molecule (ICAM), N-terminal domain
  2. NM_001099786.1NP_001093256.1  intercellular adhesion molecule 2 precursor

    See identical proteins and their annotated locations for NP_001093256.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. All 5 variants encode the same protein.
    Source sequence(s)
    AK223219, BX363874, CA841927
    Consensus CDS
    CCDS11657.1
    UniProtKB/Swiss-Prot
    P13598
    UniProtKB/TrEMBL
    Q6FHE2
    Related
    ENSP00000415283.1, ENST00000412356.5
    Conserved Domains (2) summary
    cd05755
    Location:112211
    Ig2_ICAM-1_like; Second immunoglobulin (Ig)-like domain of intercellular cell adhesion molecule-1 (ICAM-1, CD54) and similar proteins
    pfam03921
    Location:24109
    ICAM_N; Intercellular adhesion molecule (ICAM), N-terminal domain
  3. NM_001099787.1NP_001093257.1  intercellular adhesion molecule 2 precursor

    See identical proteins and their annotated locations for NP_001093257.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. All 5 variants encode the same protein.
    Source sequence(s)
    AK223219, BX363874, CA841927
    Consensus CDS
    CCDS11657.1
    UniProtKB/Swiss-Prot
    P13598
    UniProtKB/TrEMBL
    Q6FHE2
    Related
    ENSP00000388666.1, ENST00000418105.5
    Conserved Domains (2) summary
    cd05755
    Location:112211
    Ig2_ICAM-1_like; Second immunoglobulin (Ig)-like domain of intercellular cell adhesion molecule-1 (ICAM-1, CD54) and similar proteins
    pfam03921
    Location:24109
    ICAM_N; Intercellular adhesion molecule (ICAM), N-terminal domain
  4. NM_001099788.1NP_001093258.1  intercellular adhesion molecule 2 precursor

    See identical proteins and their annotated locations for NP_001093258.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. All 5 variants encode the same protein.
    Source sequence(s)
    AK223219, CA841927
    Consensus CDS
    CCDS11657.1
    UniProtKB/Swiss-Prot
    P13598
    UniProtKB/TrEMBL
    Q6FHE2
    Related
    ENSP00000462579.1, ENST00000579687.5
    Conserved Domains (2) summary
    cd05755
    Location:112211
    Ig2_ICAM-1_like; Second immunoglobulin (Ig)-like domain of intercellular cell adhesion molecule-1 (ICAM-1, CD54) and similar proteins
    pfam03921
    Location:24109
    ICAM_N; Intercellular adhesion molecule (ICAM), N-terminal domain
  5. NM_001099789.2NP_001093259.1  intercellular adhesion molecule 2 precursor

    See identical proteins and their annotated locations for NP_001093259.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. All 5 variants encode the same protein.
    Source sequence(s)
    AK223219, CA841927
    Consensus CDS
    CCDS11657.1
    UniProtKB/Swiss-Prot
    P13598
    UniProtKB/TrEMBL
    Q6FHE2
    Related
    ENSP00000464665.1, ENST00000579788.5
    Conserved Domains (2) summary
    cd05755
    Location:112211
    Ig2_ICAM-1_like; Second immunoglobulin (Ig)-like domain of intercellular cell adhesion molecule-1 (ICAM-1, CD54) and similar proteins
    pfam03921
    Location:24109
    ICAM_N; Intercellular adhesion molecule (ICAM), N-terminal domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p12 Primary Assembly

    Range
    64002595..64020634 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Support Center