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ICAM2 intercellular adhesion molecule 2 [ Homo sapiens (human) ]

Gene ID: 3384, updated on 1-Aug-2020

Summary

Official Symbol
ICAM2provided by HGNC
Official Full Name
intercellular adhesion molecule 2provided by HGNC
Primary source
HGNC:HGNC:5345
See related
Ensembl:ENSG00000108622 MIM:146630
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CD102
Summary
The protein encoded by this gene is a member of the intercellular adhesion molecule (ICAM) family. All ICAM proteins are type I transmembrane glycoproteins, contain 2-9 immunoglobulin-like C2-type domains, and bind to the leukocyte adhesion LFA-1 protein. This protein may play a role in lymphocyte recirculation by blocking LFA-1-dependent cell adhesion. It mediates adhesive interactions important for antigen-specific immune response, NK-cell mediated clearance, lymphocyte recirculation, and other cellular interactions important for immune response and surveillance. Several transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
Expression
Broad expression in spleen (RPKM 62.3), placenta (RPKM 26.4) and 17 other tissues See more
Orthologs

Genomic context

See ICAM2 in Genome Data Viewer
Location:
17q23.3
Exon count:
6
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 17 NC_000017.11 (64002595..64020634, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (62079955..62097994, complement)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene sodium voltage-gated channel alpha subunit 4 Neighboring gene uncharacterized LOC105371858 Neighboring gene PRR29 antisense RNA 1 Neighboring gene proline rich 29 Neighboring gene CRISPRi-validated cis-regulatory element chr17.4314 Neighboring gene CRISPRi-validated cis-regulatory element chr17.4315

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Replication interactions

Interaction Pubs
HIV-1 infection (VSV-G pseudotyped) of CEMT4 T cells downregulates plasma membrane expression of ICAM2 PubMed

Protein interactions

Protein Gene Interaction Pubs
Nef nef Both HIV-1 Nef and Vpu downregulate the cell surface expression of intercellular adhesion molecule 2 (ICAM2, CD102) PubMed
Vpu vpu Both HIV-1 Nef and Vpu downregulate the cell surface expression of intercellular adhesion molecule 2 (ICAM2, CD102) PubMed
vpu HIV-1 Vpu is identified to have a physical interaction with intercellular adhesion molecule 2 (ICAM2) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
integrin binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
integrin binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
cell adhesion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cell-cell adhesion IEA
Inferred from Electronic Annotation
more info
 
extracellular matrix organization TAS
Traceable Author Statement
more info
 
regulation of immune response TAS
Traceable Author Statement
more info
 
stimulatory C-type lectin receptor signaling pathway TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
cleavage furrow IDA
Inferred from Direct Assay
more info
PubMed 
integral component of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
membrane HDA PubMed 
microvillus ISS
Inferred from Sequence or Structural Similarity
more info
 
plasma membrane TAS
Traceable Author Statement
more info
 
uropod IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
intercellular adhesion molecule 2
Names
ICAM-2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_000873.3NP_000864.2  intercellular adhesion molecule 2 precursor

    See identical proteins and their annotated locations for NP_000864.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR compared to variant 1. All 5 variants encode the same protein.
    Source sequence(s)
    AK223219, BM695682
    Consensus CDS
    CCDS11657.1
    UniProtKB/Swiss-Prot
    P13598
    UniProtKB/TrEMBL
    Q6FHE2
    Related
    ENSP00000392634.2, ENST00000449662.6
    Conserved Domains (2) summary
    cd05755
    Location:112211
    Ig2_ICAM-1_like; Second immunoglobulin (Ig)-like domain of intercellular cell adhesion molecule-1 (ICAM-1, CD54) and similar proteins
    pfam03921
    Location:24109
    ICAM_N; Intercellular adhesion molecule (ICAM), N-terminal domain
  2. NM_001099786.1NP_001093256.1  intercellular adhesion molecule 2 precursor

    See identical proteins and their annotated locations for NP_001093256.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. All 5 variants encode the same protein.
    Source sequence(s)
    AK223219, BX363874, CA841927
    Consensus CDS
    CCDS11657.1
    UniProtKB/Swiss-Prot
    P13598
    UniProtKB/TrEMBL
    Q6FHE2
    Related
    ENSP00000415283.1, ENST00000412356.5
    Conserved Domains (2) summary
    cd05755
    Location:112211
    Ig2_ICAM-1_like; Second immunoglobulin (Ig)-like domain of intercellular cell adhesion molecule-1 (ICAM-1, CD54) and similar proteins
    pfam03921
    Location:24109
    ICAM_N; Intercellular adhesion molecule (ICAM), N-terminal domain
  3. NM_001099787.1NP_001093257.1  intercellular adhesion molecule 2 precursor

    See identical proteins and their annotated locations for NP_001093257.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. All 5 variants encode the same protein.
    Source sequence(s)
    AK223219, BX363874, CA841927
    Consensus CDS
    CCDS11657.1
    UniProtKB/Swiss-Prot
    P13598
    UniProtKB/TrEMBL
    Q6FHE2
    Related
    ENSP00000388666.1, ENST00000418105.5
    Conserved Domains (2) summary
    cd05755
    Location:112211
    Ig2_ICAM-1_like; Second immunoglobulin (Ig)-like domain of intercellular cell adhesion molecule-1 (ICAM-1, CD54) and similar proteins
    pfam03921
    Location:24109
    ICAM_N; Intercellular adhesion molecule (ICAM), N-terminal domain
  4. NM_001099788.1NP_001093258.1  intercellular adhesion molecule 2 precursor

    See identical proteins and their annotated locations for NP_001093258.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. All 5 variants encode the same protein.
    Source sequence(s)
    AK223219, CA841927
    Consensus CDS
    CCDS11657.1
    UniProtKB/Swiss-Prot
    P13598
    UniProtKB/TrEMBL
    Q6FHE2
    Related
    ENSP00000462579.1, ENST00000579687.5
    Conserved Domains (2) summary
    cd05755
    Location:112211
    Ig2_ICAM-1_like; Second immunoglobulin (Ig)-like domain of intercellular cell adhesion molecule-1 (ICAM-1, CD54) and similar proteins
    pfam03921
    Location:24109
    ICAM_N; Intercellular adhesion molecule (ICAM), N-terminal domain
  5. NM_001099789.2NP_001093259.1  intercellular adhesion molecule 2 precursor

    See identical proteins and their annotated locations for NP_001093259.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. All 5 variants encode the same protein.
    Source sequence(s)
    AK223219, CA841927
    Consensus CDS
    CCDS11657.1
    UniProtKB/Swiss-Prot
    P13598
    UniProtKB/TrEMBL
    Q6FHE2
    Related
    ENSP00000464665.1, ENST00000579788.6
    Conserved Domains (2) summary
    cd05755
    Location:112211
    Ig2_ICAM-1_like; Second immunoglobulin (Ig)-like domain of intercellular cell adhesion molecule-1 (ICAM-1, CD54) and similar proteins
    pfam03921
    Location:24109
    ICAM_N; Intercellular adhesion molecule (ICAM), N-terminal domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109.20200522

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p13 Primary Assembly

    Range
    64002595..64020634 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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