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SPAAR small regulatory polypeptide of amino acid response [ Homo sapiens (human) ]

Gene ID: 158376, updated on 25-Jan-2022

Summary

Official Symbol
SPAARprovided by HGNC
Official Full Name
small regulatory polypeptide of amino acid responseprovided by HGNC
Primary source
HGNC:HGNC:27244
See related
Ensembl:ENSG00000235387 MIM:617627; AllianceGenome:HGNC:27244
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SPAR; LINC00961
Summary
Involved in cellular response to amino acid stimulus and negative regulation of TORC1 signaling. Located in late endosome membrane. Is integral component of lysosomal membrane. Colocalizes with lysosomal proton-transporting V-type ATPase complex. [provided by Alliance of Genome Resources, Nov 2021]
Expression
Biased expression in fat (RPKM 6.4), testis (RPKM 5.2) and 8 other tissues See more
Orthologs
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Genomic context

See SPAAR in Genome Data Viewer
Location:
9p13.3
Exon count:
2
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 9 NC_000009.12 (35909490..35911686)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (35909487..35911683)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene NADH:ubiquinone oxidoreductase subunit A5 pseudogene 4 Neighboring gene histidine rich carboxyl terminus 1 Neighboring gene phosphoglycerate mutase 1 pseudogene 2 Neighboring gene olfactory receptor family 2 subfamily S member 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

General protein information

Preferred Names
small regulatory polypeptide of amino acid response
Names
long intergenic non-protein coding RNA 961
small regulatory polypeptide of amino acids response

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001348107.3NP_001335036.2  small regulatory polypeptide of amino acid response

    Status: VALIDATED

    Source sequence(s)
    AA807870, AK056723, AL135841, BC113682
    Related
    ENSP00000490187.1, ENST00000443779.3

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p13 Primary Assembly

    Range
    35909490..35911686
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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