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LINGO2 leucine rich repeat and Ig domain containing 2 [ Homo sapiens (human) ]

Gene ID: 158038, updated on 11-Jun-2021

Summary

Official Symbol
LINGO2provided by HGNC
Official Full Name
leucine rich repeat and Ig domain containing 2provided by HGNC
Primary source
HGNC:HGNC:21207
See related
Ensembl:ENSG00000174482 MIM:609793
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
LERN3; LRRN6C
Expression
Low expression observed in reference dataset See more
Orthologs
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Genomic context

See LINGO2 in Genome Data Viewer
Location:
9p21.2-p21.1
Exon count:
16
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 9 NC_000009.12 (27937617..29215243, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (27937615..29213599, complement)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107987058 Neighboring gene uncharacterized LOC105376002 Neighboring gene putative UPF0607 protein ENSP00000383783 pseudogene Neighboring gene uncharacterized LOC105376004 Neighboring gene uncharacterized LOC105376003 Neighboring gene potassium channel tetramerization domain containing 10 pseudogene 1 Neighboring gene microRNA 876 Neighboring gene microRNA 873 Neighboring gene pyruvate dehydrogenase kinase 1 pseudogene 1 Neighboring gene uncharacterized LOC105376005

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index.
GeneReviews: Not available
Association of IFIH1 and other autoimmunity risk alleles with selective IgA deficiency.
GeneReviews: Not available
Genome-wide association study of endometrial cancer in E2C2.
GeneReviews: Not available
Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture.
GeneReviews: Not available
Genome-wide survival analysis of age at onset of alcohol dependence in extended high-risk COGA families.
GeneReviews: Not available
Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers.
GeneReviews: Not available
Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
GeneReviews: Not available
Sequence variants in SLC16A11 are a common risk factor for type 2 diabetes in Mexico.
GeneReviews: Not available

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ31810

Gene Ontology Provided by GOA

Process Evidence Code Pubs
involved_in positive regulation of synapse assembly IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in extracellular matrix IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in integral component of membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 2
Names
leucine rich repeat neuronal 6C
leucine-rich repeat neuronal protein 3
leucine-rich repeat neuronal protein 6C

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001258282.3NP_001245211.1  leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 2 precursor

    See identical proteins and their annotated locations for NP_001245211.1

    Status: VALIDATED

    Source sequence(s)
    AL158072, AL162388, AL353683, AL353746, AL592206, AL596323, BX538226
    Consensus CDS
    CCDS6524.1
    UniProtKB/Swiss-Prot
    Q7L985
    Conserved Domains (6) summary
    TIGR00864
    Location:327391
    PCC; polycystin cation channel protein
    smart00013
    Location:2760
    LRRNT; Leucine rich repeat N-terminal domain
    pfam07679
    Location:410500
    I-set; Immunoglobulin I-set domain
    sd00033
    Location:83106
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:106165
    LRR_8; Leucine rich repeat
    cl26222
    Location:146276
    LRR_5; Leucine rich repeats (6 copies)
  2. NM_001354574.2NP_001341503.1  leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 2 precursor

    Status: VALIDATED

    Source sequence(s)
    AL158072, AL162388, AL353683, AL353746, AL592206, AL596323, BX538226
    Consensus CDS
    CCDS6524.1
    Related
    ENSP00000479634.1, ENST00000613945.3
    Conserved Domains (6) summary
    TIGR00864
    Location:327391
    PCC; polycystin cation channel protein
    smart00013
    Location:2760
    LRRNT; Leucine rich repeat N-terminal domain
    pfam07679
    Location:410500
    I-set; Immunoglobulin I-set domain
    sd00033
    Location:83106
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:106165
    LRR_8; Leucine rich repeat
    cl26222
    Location:146276
    LRR_5; Leucine rich repeats (6 copies)
  3. NM_001354575.2NP_001341504.1  leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 2 precursor

    Status: VALIDATED

    Source sequence(s)
    AL158072, AL162388, AL353683, AL353746, AL592206, AL596323, BX538226
    Consensus CDS
    CCDS6524.1
    Conserved Domains (6) summary
    TIGR00864
    Location:327391
    PCC; polycystin cation channel protein
    smart00013
    Location:2760
    LRRNT; Leucine rich repeat N-terminal domain
    pfam07679
    Location:410500
    I-set; Immunoglobulin I-set domain
    sd00033
    Location:83106
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:106165
    LRR_8; Leucine rich repeat
    cl26222
    Location:146276
    LRR_5; Leucine rich repeats (6 copies)
  4. NM_152570.4NP_689783.1  leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 2 precursor

    See identical proteins and their annotated locations for NP_689783.1

    Status: VALIDATED

    Source sequence(s)
    AL353683, AL353746, AL450428, AL592206, AL596323, BX538226
    Consensus CDS
    CCDS6524.1
    UniProtKB/Swiss-Prot
    Q7L985
    Related
    ENSP00000369328.1, ENST00000379992.6
    Conserved Domains (6) summary
    TIGR00864
    Location:327391
    PCC; polycystin cation channel protein
    smart00013
    Location:2760
    LRRNT; Leucine rich repeat N-terminal domain
    pfam07679
    Location:410500
    I-set; Immunoglobulin I-set domain
    sd00033
    Location:83106
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:106165
    LRR_8; Leucine rich repeat
    cl26222
    Location:146276
    LRR_5; Leucine rich repeats (6 copies)

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p13 Primary Assembly

    Range
    27937617..29215243 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017014303.2XP_016869792.1  leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 2 isoform X1

    UniProtKB/Swiss-Prot
    Q7L985
    Conserved Domains (6) summary
    TIGR00864
    Location:327391
    PCC; polycystin cation channel protein
    smart00013
    Location:2760
    LRRNT; Leucine rich repeat N-terminal domain
    pfam07679
    Location:410500
    I-set; Immunoglobulin I-set domain
    sd00033
    Location:83106
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:106165
    LRR_8; Leucine rich repeat
    cl26222
    Location:146276
    LRR_5; Leucine rich repeats (6 copies)
  2. XM_011517728.2XP_011516030.1  leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 2 isoform X1

    See identical proteins and their annotated locations for XP_011516030.1

    UniProtKB/Swiss-Prot
    Q7L985
    Conserved Domains (6) summary
    TIGR00864
    Location:327391
    PCC; polycystin cation channel protein
    smart00013
    Location:2760
    LRRNT; Leucine rich repeat N-terminal domain
    pfam07679
    Location:410500
    I-set; Immunoglobulin I-set domain
    sd00033
    Location:83106
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:106165
    LRR_8; Leucine rich repeat
    cl26222
    Location:146276
    LRR_5; Leucine rich repeats (6 copies)
  3. XM_011517724.2XP_011516026.1  leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 2 isoform X1

    See identical proteins and their annotated locations for XP_011516026.1

    UniProtKB/Swiss-Prot
    Q7L985
    Conserved Domains (6) summary
    TIGR00864
    Location:327391
    PCC; polycystin cation channel protein
    smart00013
    Location:2760
    LRRNT; Leucine rich repeat N-terminal domain
    pfam07679
    Location:410500
    I-set; Immunoglobulin I-set domain
    sd00033
    Location:83106
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:106165
    LRR_8; Leucine rich repeat
    cl26222
    Location:146276
    LRR_5; Leucine rich repeats (6 copies)
  4. XM_017014305.1XP_016869794.1  leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 2 isoform X1

    UniProtKB/Swiss-Prot
    Q7L985
    Conserved Domains (6) summary
    TIGR00864
    Location:327391
    PCC; polycystin cation channel protein
    smart00013
    Location:2760
    LRRNT; Leucine rich repeat N-terminal domain
    pfam07679
    Location:410500
    I-set; Immunoglobulin I-set domain
    sd00033
    Location:83106
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:106165
    LRR_8; Leucine rich repeat
    cl26222
    Location:146276
    LRR_5; Leucine rich repeats (6 copies)
  5. XM_017014304.1XP_016869793.1  leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 2 isoform X1

    UniProtKB/Swiss-Prot
    Q7L985
    Conserved Domains (6) summary
    TIGR00864
    Location:327391
    PCC; polycystin cation channel protein
    smart00013
    Location:2760
    LRRNT; Leucine rich repeat N-terminal domain
    pfam07679
    Location:410500
    I-set; Immunoglobulin I-set domain
    sd00033
    Location:83106
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:106165
    LRR_8; Leucine rich repeat
    cl26222
    Location:146276
    LRR_5; Leucine rich repeats (6 copies)
  6. XM_017014306.2XP_016869795.1  leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 2 isoform X1

    UniProtKB/Swiss-Prot
    Q7L985
    Conserved Domains (6) summary
    TIGR00864
    Location:327391
    PCC; polycystin cation channel protein
    smart00013
    Location:2760
    LRRNT; Leucine rich repeat N-terminal domain
    pfam07679
    Location:410500
    I-set; Immunoglobulin I-set domain
    sd00033
    Location:83106
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:106165
    LRR_8; Leucine rich repeat
    cl26222
    Location:146276
    LRR_5; Leucine rich repeats (6 copies)
  7. XM_017014307.1XP_016869796.1  leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 2 isoform X1

    UniProtKB/Swiss-Prot
    Q7L985
    Conserved Domains (6) summary
    TIGR00864
    Location:327391
    PCC; polycystin cation channel protein
    smart00013
    Location:2760
    LRRNT; Leucine rich repeat N-terminal domain
    pfam07679
    Location:410500
    I-set; Immunoglobulin I-set domain
    sd00033
    Location:83106
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:106165
    LRR_8; Leucine rich repeat
    cl26222
    Location:146276
    LRR_5; Leucine rich repeats (6 copies)

RNA

  1. XR_001746186.2 RNA Sequence

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