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CYP4A11 cytochrome P450 family 4 subfamily A member 11 [ Homo sapiens (human) ]

Gene ID: 1579, updated on 21-Dec-2019

Summary

Official Symbol
CYP4A11provided by HGNC
Official Full Name
cytochrome P450 family 4 subfamily A member 11provided by HGNC
Primary source
HGNC:HGNC:2642
See related
Ensembl:ENSG00000187048 MIM:601310
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CP4Y; CYP4A2; CYP4AII; CYPIVA11
Summary
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and hydroxylates medium-chain fatty acids such as laurate and myristate. Multiple transcript variants have been found for this gene. [provided by RefSeq, Jan 2016]
Expression
Biased expression in liver (RPKM 280.4) and kidney (RPKM 130.2) See more
Orthologs

Genomic context

See CYP4A11 in Genome Data Viewer
Location:
1p33
Exon count:
13
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (46929177..46941476, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (47394846..47407156, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene cytochrome P450 family 4 subfamily B member 1 Neighboring gene cytochrome P450 family 4 subfamily Z member 2, pseudogene Neighboring gene tubulin alpha 1c pseudogene Neighboring gene cytochrome P450 family 4 subfamily A member 26, pseudogene Neighboring gene cytochrome P450 family 4 subfamily X member 1 Neighboring gene cytochrome P450 family 4 subfamily A member 43, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
An atlas of genetic influences on human blood metabolites.
NHGRI GWA Catalog
Human metabolic individuality in biomedical and pharmaceutical research.
NHGRI GWA Catalog

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
alkane 1-monooxygenase activity IDA
Inferred from Direct Assay
more info
PubMed 
arachidonic acid epoxygenase activity IDA
Inferred from Direct Assay
more info
PubMed 
aromatase activity IEA
Inferred from Electronic Annotation
more info
 
heme binding IEA
Inferred from Electronic Annotation
more info
 
iron ion binding IEA
Inferred from Electronic Annotation
more info
 
leukotriene-B4 20-monooxygenase activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
arachidonic acid metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
epoxygenase P450 pathway IDA
Inferred from Direct Assay
more info
PubMed 
fatty acid metabolic process TAS
Traceable Author Statement
more info
 
leukotriene B4 catabolic process IEA
Inferred from Electronic Annotation
more info
 
leukotriene metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
long-chain fatty acid metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
omega-hydroxylase P450 pathway TAS
Traceable Author Statement
more info
 
oxidation-reduction process IDA
Inferred from Direct Assay
more info
PubMed 
oxylipin biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
positive regulation of icosanoid secretion IMP
Inferred from Mutant Phenotype
more info
PubMed 
pressure natriuresis IEP
Inferred from Expression Pattern
more info
PubMed 
regulation of lipid metabolic process TAS
Traceable Author Statement
more info
 
renal water homeostasis IEP
Inferred from Expression Pattern
more info
PubMed 
sodium ion homeostasis IEP
Inferred from Expression Pattern
more info
PubMed 
Component Evidence Code Pubs
apical plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
endoplasmic reticulum membrane TAS
Traceable Author Statement
more info
 
intracellular membrane-bounded organelle IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
cytochrome P450 4A11
Names
20-HETE synthase
20-hydroxyeicosatetraenoic acid synthase
P450HL-omega
alkane-1 monooxygenase
cytochrome P-450HK-omega
cytochrome P450, family 4, subfamily A, polypeptide 11
cytochrome P450, subfamily IVA, polypeptide 11
cytochrome P450HL-omega
fatty acid omega-hydroxylase
lauric acid omega-hydroxylase
long-chain fatty acid omega-monooxygenase
NP_000769.2
NP_001306084.1
NP_001350516.1
XP_005270596.1
XP_016855954.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_007932.1 RefSeqGene

    Range
    5009..17297
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_000778.4NP_000769.2  cytochrome P450 4A11 isoform 1

    See identical proteins and their annotated locations for NP_000769.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AL731892, CD014132, D26481, S67580
    Consensus CDS
    CCDS543.1
    UniProtKB/Swiss-Prot
    Q02928
    Related
    ENSP00000311095.4, ENST00000310638.9
    Conserved Domains (1) summary
    pfam00067
    Location:52505
    p450; Cytochrome P450
  2. NM_001319155.2NP_001306084.1  cytochrome P450 4A11 isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice junction compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    AL731892, CD013974, L04751
    UniProtKB/Swiss-Prot
    Q02928
    Conserved Domains (1) summary
    pfam00067
    Location:52473
    p450; Cytochrome P450
  3. NM_001363587.2NP_001350516.1  cytochrome P450 4A11 isoform 3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (10) has multiple differences in the coding region compared to variant 1. The resulting isoform (3) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    AL731892
    Consensus CDS
    CCDS85973.1
    Related
    ENSP00000477495.1, ENST00000462347.5
    Conserved Domains (1) summary
    pfam00067
    Location:52407
    p450; Cytochrome P450

RNA

  1. NR_134988.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks two alternate exons compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AL731892, CD013975, L04751
  2. NR_134989.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) lacks an alternate exon compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AL731892, CD013976, L04751
  3. NR_134990.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) uses an alternate splice junction and lacks an alternate exon compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AL731892, CD013977, L04751
  4. NR_134991.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) uses an alternate splice junction and lacks an alternate exon compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AL731892, CD013978, L04751
  5. NR_134992.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7) lacks four alternate exon compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AL731892, CD013979, L04751
  6. NR_134993.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (8) lacks three alternate exons compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AL731892, CD013980, L04751
    Related
    ENST00000475477.5
  7. NR_134994.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (9) uses an alternate splice junction and lacks an alternate exon compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AL731892, CD014132, L04751

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    46929177..46941476 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017000465.1XP_016855954.1  cytochrome P450 4A11 isoform X2

  2. XM_005270539.1XP_005270596.1  cytochrome P450 4A11 isoform X3

    Conserved Domains (1) summary
    cl12078
    Location:52357
    p450; Cytochrome P450

RNA

  1. XR_001737005.1 RNA Sequence

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