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Htr1a 5-hydroxytryptamine (serotonin) receptor 1A [ Mus musculus (house mouse) ]

Gene ID: 15550, updated on 8-Feb-2024

Summary

Official Symbol
Htr1aprovided by MGI
Official Full Name
5-hydroxytryptamine (serotonin) receptor 1Aprovided by MGI
Primary source
MGI:MGI:96273
See related
Ensembl:ENSMUSG00000021721 AllianceGenome:MGI:96273
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Gpcr18
Summary
Enables G protein-coupled serotonin receptor activity. Involved in several processes, including behavioral fear response; serotonin metabolic process; and serotonin receptor signaling pathway. Acts upstream of or within gamma-aminobutyric acid signaling pathway. Predicted to be located in axon hillock. Predicted to be active in dendrite. Predicted to be integral component of plasma membrane. Is expressed in several structures, including central nervous system; exocrine gland; eye; genitourinary system; and intestine. Used to study anxiety disorder. Human ortholog(s) of this gene implicated in anxiety disorder; mental depression; and panic disorder. Orthologous to human HTR1A (5-hydroxytryptamine receptor 1A). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

See Htr1a in Genome Data Viewer
Location:
13 D1; 13 56.92 cM
Exon count:
1
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (105580040..105584630)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (105443693..105448133)

Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 41049 Neighboring gene predicted gene, 31130 Neighboring gene STARR-seq mESC enhancer starr_35552 Neighboring gene predicted gene, 41050 Neighboring gene STARR-seq mESC enhancer starr_35553 Neighboring gene VISTA enhancer mm5 Neighboring gene predicted gene, 57602

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (11)  1 citation
  • Endonuclease-mediated (3) 

Pathways from PubChem

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables G protein-coupled receptor activity IEA
Inferred from Electronic Annotation
more info
 
enables G protein-coupled serotonin receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables G protein-coupled serotonin receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
enables G protein-coupled serotonin receptor activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables G protein-coupled serotonin receptor activity ISO
Inferred from Sequence Orthology
more info
 
enables G-protein alpha-subunit binding ISO
Inferred from Sequence Orthology
more info
 
enables neurotransmitter receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables receptor-receptor interaction ISO
Inferred from Sequence Orthology
more info
 
enables serotonin binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables serotonin binding ISO
Inferred from Sequence Orthology
more info
 
enables signaling receptor binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within G protein-coupled serotonin receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in NMDA glutamate receptor clustering ISO
Inferred from Sequence Orthology
more info
 
involved_in adenylate cyclase-inhibiting serotonin receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in adenylate cyclase-inhibiting serotonin receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within behavior IEA
Inferred from Electronic Annotation
more info
 
involved_in behavioral fear response IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in chemical synaptic transmission IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in exploration behavior IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within gamma-aminobutyric acid signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of gamma-aminobutyric acid secretion ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of microtubule depolymerization ISO
Inferred from Sequence Orthology
more info
 
involved_in presynaptic modulation of chemical synaptic transmission ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of behavior IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of dopamine metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of feeding behavior ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of hormone secretion IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of serotonin secretion IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of vasoconstriction IEA
Inferred from Electronic Annotation
more info
 
involved_in serotonin metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in serotonin receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in serotonin receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within signal transduction IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in GABA-ergic synapse ISO
Inferred from Sequence Orthology
more info
 
located_in axon hillock ISO
Inferred from Sequence Orthology
more info
 
located_in cell projection IEA
Inferred from Electronic Annotation
more info
 
is_active_in dendrite IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in neuronal cell body ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
is_active_in presynaptic membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
5-hydroxytryptamine receptor 1A
Names
5-HT-1A
5-HT1A receptor
G-protein coupled receptor 18
serotonin receptor 1A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_008308.5NP_032334.2  5-hydroxytryptamine receptor 1A

    See identical proteins and their annotated locations for NP_032334.2

    Status: VALIDATED

    Source sequence(s)
    AC114573
    Consensus CDS
    CCDS26756.1
    UniProtKB/Swiss-Prot
    Q60956, Q61617, Q64264, Q8BGS4
    UniProtKB/TrEMBL
    Q8BZP1
    Related
    ENSMUSP00000022235.5, ENSMUST00000022235.6
    Conserved Domains (2) summary
    pfam00001
    Location:53400
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    cl21561
    Location:48169
    7tm_4; Olfactory receptor

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000079.7 Reference GRCm39 C57BL/6J

    Range
    105580040..105584630
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)