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HTR1A 5-hydroxytryptamine receptor 1A [ Homo sapiens (human) ]

Gene ID: 3350, updated on 24-Nov-2020

Summary

Official Symbol
HTR1Aprovided by HGNC
Official Full Name
5-hydroxytryptamine receptor 1Aprovided by HGNC
Primary source
HGNC:HGNC:5286
See related
Ensembl:ENSG00000178394 MIM:109760
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
G-21; 5HT1a; PFMCD; 5-HT1A; 5-HT-1A; ADRBRL1; ADRB2RL1
Summary
This gene encodes a G protein-coupled receptor for 5-hydroxytryptamine (serotonin), and belongs to the 5-hydroxytryptamine receptor subfamily. Serotonin has been implicated in a number of physiologic processes and pathologic conditions. Inactivation of this gene in mice results in behavior consistent with an increased anxiety and stress response. Mutation in the promoter of this gene has been associated with menstrual cycle-dependent periodic fevers. [provided by RefSeq, Jun 2012]
Orthologs

Genomic context

See HTR1A in Genome Data Viewer
Location:
5q12.3
Exon count:
1
Annotation release Status Assembly Chr Location
109.20201120 current GRCh38.p13 (GCF_000001405.39) 5 NC_000005.10 (63957874..63962445, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (63255875..63258119, complement)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107986416 Neighboring gene uncharacterized LOC105378999 Neighboring gene ring finger protein 180 Neighboring gene RNA, 7SL, cytoplasmic 169, pseudogene Neighboring gene regulator of G protein signaling 7 binding protein

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
A genome-wide association study (GWAS) for bronchopulmonary dysplasia.
GeneReviews: Not available
Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index.
GeneReviews: Not available
Genome-wide contribution of genotype by environment interaction to variation of diabetes-related traits.
GeneReviews: Not available
Genome-wide significant association signals in IPO11-HTR1A region specific for alcohol and nicotine codependence.
GeneReviews: Not available
Periodic fever, menstrual cycle-dependent
MedGen: C3553418 OMIM: 614674 GeneReviews: Not available
Compare labs

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
G protein-coupled serotonin receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
G protein-coupled serotonin receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
G protein-coupled serotonin receptor activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
neurotransmitter receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
receptor-receptor interaction IDA
Inferred from Direct Assay
more info
PubMed 
serotonin binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
G protein-coupled receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
G protein-coupled receptor signaling pathway TAS
Traceable Author Statement
more info
 
G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
adenylate cyclase-inhibiting serotonin receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
adenylate cyclase-inhibiting serotonin receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
behavioral fear response ISS
Inferred from Sequence or Structural Similarity
more info
 
cell population proliferation IEA
Inferred from Electronic Annotation
more info
 
chemical synaptic transmission IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
exploration behavior ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of cell population proliferation TAS
Traceable Author Statement
more info
PubMed 
regulation of behavior IEA
Inferred from Electronic Annotation
more info
 
regulation of dopamine metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of hormone secretion IEA
Inferred from Electronic Annotation
more info
 
regulation of serotonin secretion ISS
Inferred from Sequence or Structural Similarity
more info
 
serotonin metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
 
serotonin receptor signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
vasoconstriction IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
dendrite IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
integral component of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
integral component of plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 
synapse IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
5-hydroxytryptamine receptor 1A
Names
5-HT1a receptor
5-hydroxytryptamine (serotonin) receptor 1A, G protein-coupled
guanine nucleotide-binding regulatory protein-coupled receptor

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_032816.1 RefSeqGene

    Range
    5001..7245
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_000524.4NP_000515.2  5-hydroxytryptamine receptor 1A

    See identical proteins and their annotated locations for NP_000515.2

    Status: VALIDATED

    Source sequence(s)
    AC122707
    Consensus CDS
    CCDS34168.1
    UniProtKB/Swiss-Prot
    P08908
    UniProtKB/TrEMBL
    A8K5W4, Q5ZGX3
    Related
    ENSP00000316244.3, ENST00000323865.4
    Conserved Domains (2) summary
    pfam00001
    Location:53400
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    cl21561
    Location:48169
    7tm_4; Olfactory receptor

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20201120

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p13 Primary Assembly

    Range
    63957874..63962445 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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