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Hspb1 heat shock protein 1 [ Mus musculus (house mouse) ]

Gene ID: 15507, updated on 5-Aug-2018

Summary

Official Symbol
Hspb1provided by MGI
Official Full Name
heat shock protein 1provided by MGI
Primary source
MGI:MGI:96240
See related
Ensembl:ENSMUSG00000004951 Vega:OTTMUSG00000024281
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
27kDa; Hsp25
Expression
Biased expression in stomach adult (RPKM 786.6), placenta adult (RPKM 259.7) and 13 other tissues See more
Orthologs

Genomic context

See Hspb1 in Genome Data Viewer
Location:
5 G2; 5 75.51 cM
Exon count:
3
Annotation release Status Assembly Chr Location
106 current GRCm38.p4 (GCF_000001635.24) 5 NC_000071.6 (135887919..135889563)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 5 NC_000071.5 (136363789..136365433)

Chromosome 5 - NC_000071.6Genomic Context describing neighboring genes Neighboring gene malate dehydrogenase 2, NAD (mitochondrial) Neighboring gene serine/arginine repetitive matrix 3 Neighboring gene tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide Neighboring gene predicted gene, 40346 Neighboring gene scavenger receptor cysteine rich family, 4 domains

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
identical protein binding ISO
Inferred from Sequence Orthology
more info
 
protein binding involved in protein folding ISO
Inferred from Sequence Orthology
more info
 
protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
 
protein kinase C binding IDA
Inferred from Direct Assay
more info
PubMed 
protein kinase C inhibitor activity IDA
Inferred from Direct Assay
more info
PubMed 
protein kinase binding ISO
Inferred from Sequence Orthology
more info
 
ubiquitin binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
anterograde axonal protein transport ISO
Inferred from Sequence Orthology
more info
 
cellular response to vascular endothelial growth factor stimulus ISO
Inferred from Sequence Orthology
more info
 
chaperone-mediated protein folding ISO
Inferred from Sequence Orthology
more info
 
intracellular signal transduction ISO
Inferred from Sequence Orthology
more info
 
negative regulation of apoptotic signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of oxidative stress-induced cell death ISO
Inferred from Sequence Orthology
more info
 
negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of protein kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of angiogenesis ISO
Inferred from Sequence Orthology
more info
 
positive regulation of blood vessel endothelial cell migration ISO
Inferred from Sequence Orthology
more info
 
positive regulation of endothelial cell chemotaxis ISO
Inferred from Sequence Orthology
more info
 
positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
positive regulation of interleukin-1 beta production IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of neuron projection development ISO
Inferred from Sequence Orthology
more info
 
positive regulation of tumor necrosis factor biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
regulation of I-kappaB kinase/NF-kappaB signaling IDA
Inferred from Direct Assay
more info
PubMed 
regulation of protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
response to unfolded protein NAS
Non-traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
I band ISO
Inferred from Sequence Orthology
more info
 
M band ISO
Inferred from Sequence Orthology
more info
 
Z disc IDA
Inferred from Direct Assay
more info
PubMed 
axon ISO
Inferred from Sequence Orthology
more info
 
cardiac myofibril ISO
Inferred from Sequence Orthology
more info
 
contractile fiber IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
dendrite ISO
Inferred from Sequence Orthology
more info
 
intracellular IDA
Inferred from Direct Assay
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
nucleus ISO
Inferred from Sequence Orthology
more info
 
perikaryon ISO
Inferred from Sequence Orthology
more info
 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane ISO
Inferred from Sequence Orthology
more info
 
postsynaptic density membrane ISO
Inferred from Sequence Orthology
more info
 
proteasome complex ISO
Inferred from Sequence Orthology
more info
 
synapse ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
heat shock protein beta-1
Names
HSP 25
HSP 27
growth-related 25 kDa protein
heat shock 25 kDa protein
heat shock 27 kDa protein
heat shock 27kDa protein 1
heat shock protein, 25 kDa
p25
truncated hsp25

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_013560.2NP_038588.2  heat shock protein beta-1

    See identical proteins and their annotated locations for NP_038588.2

    Status: VALIDATED

    Source sequence(s)
    AA013886, AV458710, BC099463
    Consensus CDS
    CCDS39320.1
    UniProtKB/Swiss-Prot
    P14602
    UniProtKB/TrEMBL
    Q545F4
    Related
    ENSMUSP00000005077.6, OTTMUSP00000028918, ENSMUST00000005077.6, OTTMUST00000059461
    Conserved Domains (1) summary
    cd06475
    Location:88173
    ACD_HspB1_like; Alpha crystallin domain (ACD) found in mammalian small (s)heat shock protein (Hsp)-27 (also denoted HspB1 in human) and similar proteins. sHsps are molecular chaperones that suppress protein aggregation and protect against cell stress, and are generally ...

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p4 C57BL/6J

Genomic

  1. NC_000071.6 Reference GRCm38.p4 C57BL/6J

    Range
    135887919..135889563
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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