U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

HSPB1 heat shock protein family B (small) member 1 [ Homo sapiens (human) ]

Gene ID: 3315, updated on 6-Oct-2024

Summary

Official Symbol
HSPB1provided by HGNC
Official Full Name
heat shock protein family B (small) member 1provided by HGNC
Primary source
HGNC:HGNC:5246
See related
Ensembl:ENSG00000106211 MIM:602195; AllianceGenome:HGNC:5246
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CMT2F; HMN2B; HMND3; HSP27; HSP28; Hsp25; SRP27; HS.76067; HEL-S-102
Summary
This gene encodes a member of the small heat shock protein (HSP20) family of proteins. In response to environmental stress, the encoded protein translocates from the cytoplasm to the nucleus and functions as a molecular chaperone that promotes the correct folding of other proteins. This protein plays an important role in the differentiation of a wide variety of cell types. Expression of this gene is correlated with poor clinical outcome in multiple human cancers, and the encoded protein may promote cancer cell proliferation and metastasis, while protecting cancer cells from apoptosis. Mutations in this gene have been identified in human patients with Charcot-Marie-Tooth disease and distal hereditary motor neuropathy. [provided by RefSeq, Aug 2017]
Expression
Broad expression in esophagus (RPKM 497.4), skin (RPKM 350.7) and 23 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See HSPB1 in Genome Data Viewer
Location:
7q11.23
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (76302673..76304292)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (77590142..77591761)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (75931990..75933609)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene GTF2I repeat domain containing 1 pseudogene Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:75814843-75815508 Neighboring gene Sharpr-MPRA regulatory region 5015 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:75826515-75827312 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18306 Neighboring gene serine/arginine repetitive matrix 3 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:75852108-75852608 Neighboring gene NANOG hESC enhancer GRCh37_chr7:75853947-75854451 Neighboring gene MPRA-validated peak6610 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26193 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18307 Neighboring gene uncharacterized LOC124901679 Neighboring gene MPRA-validated peak6611 silencer Neighboring gene ReSE screen-validated silencer GRCh37_chr7:75884084-75884282 Neighboring gene Sharpr-MPRA regulatory region 1121 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18308 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:75890756-75891279 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:75896022-75896767 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26194 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26195 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18310 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:75919557-75920072 Neighboring gene CRISPRi-validated cis-regulatory element chr7.2946 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26197 Neighboring gene Sharpr-MPRA regulatory region 11180 Neighboring gene Sharpr-MPRA regulatory region 14050 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:75946434-75947430 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:75947431-75948427 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:75957380-75957880 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:75957881-75958381 Neighboring gene fibroblast proliferation associated lncRNA Neighboring gene tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma Neighboring gene ReSE screen-validated silencer GRCh37_chr7:75981845-75982083 Neighboring gene ReSE screen-validated silencer GRCh37_chr7:75987439-75987629 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:75987737-75988383

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Vif vif HIV Vif interacts with HSPB1 PubMed
Vpr vpr Activation of HSP27 is mediated through heat shock factor 1 and is counteracted by HIV-1 Vpr PubMed
vpr HSP27 reverses HIV-1 Vpr-induced G2 arrest and blocks Vpr-induced cell death and apoptosis PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • DKFZp586P1322

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables RNA binding HDA PubMed 
enables RNA polymerase II-specific DNA-binding transcription factor binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables identical protein binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein folding chaperone IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables protein homodimerization activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein kinase C binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables protein kinase C inhibitor activity ISS
Inferred from Sequence or Structural Similarity
more info
 
enables protein kinase binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables ubiquitin binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables unfolded protein binding IBA
Inferred from Biological aspect of Ancestor
more info
 
Process Evidence Code Pubs
involved_in anterograde axonal protein transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cellular response to vascular endothelial growth factor stimulus IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in chaperone-mediated protein folding IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in intracellular signal transduction IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of apoptotic process IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in negative regulation of apoptotic process TAS
Traceable Author Statement
more info
PubMed 
involved_in negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of protein kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in platelet aggregation HMP PubMed 
involved_in positive regulation of angiogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of blood vessel endothelial cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of endothelial cell chemotaxis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of interleukin-1 beta production ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of tumor necrosis factor production ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in protein refolding IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in regulation of autophagy NAS
Non-traceable Author Statement
more info
PubMed 
involved_in regulation of canonical NF-kappaB signal transduction ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in regulation of protein phosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of translational initiation TAS
Traceable Author Statement
more info
PubMed 
involved_in response to heat IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in response to unfolded protein NAS
Non-traceable Author Statement
more info
PubMed 
involved_in response to virus IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in vascular endothelial growth factor receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in Z disc IEA
Inferred from Electronic Annotation
more info
 
located_in axon cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in cornified envelope IEA
Inferred from Electronic Annotation
more info
 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm TAS
Traceable Author Statement
more info
PubMed 
located_in cytoskeleton TAS
Traceable Author Statement
more info
PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in extracellular exosome HDA PubMed 
located_in extracellular space HDA PubMed 
located_in focal adhesion HDA PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
part_of proteasome complex ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in spindle IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
heat shock protein beta-1
Names
28 kDa heat shock protein
epididymis secretory protein Li 102
estrogen-regulated 24 kDa protein
heat shock 27 kDa protein
heat shock 27kD protein 1
heat shock 27kDa protein 1
heat shock protein family B member 1
stress-responsive protein 27

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_008995.1 RefSeqGene

    Range
    5001..6740
    Download
    GenBank, FASTA, Sequence Viewer (Graphics), LRG_248

mRNA and Protein(s)

  1. NM_001540.5NP_001531.1  heat shock protein beta-1

    See identical proteins and their annotated locations for NP_001531.1

    Status: REVIEWED

    Source sequence(s)
    BC012768, BP231480
    Consensus CDS
    CCDS5583.1
    UniProtKB/Swiss-Prot
    B2R4N8, P04792, Q6FI47, Q96C20, Q96EI7, Q9UC31, Q9UC34, Q9UC35, Q9UC36
    UniProtKB/TrEMBL
    A0A6Q8PFK8, V9HW43
    Related
    ENSP00000248553.6, ENST00000248553.7
    Conserved Domains (1) summary
    cd06475
    Location:84169
    ACD_HspB1_like; Alpha crystallin domain (ACD) found in mammalian small (s)heat shock protein (Hsp)-27 (also denoted HspB1 in human) and similar proteins. sHsps are molecular chaperones that suppress protein aggregation and protect against cell stress, and are generally ...

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

    Range
    76302673..76304292
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060931.1 Alternate T2T-CHM13v2.0

    Range
    77590142..77591761
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)