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Dnaja1 DnaJ heat shock protein family (Hsp40) member A1 [ Mus musculus (house mouse) ]

Gene ID: 15502, updated on 8-Jan-2023

Summary

Official Symbol
Dnaja1provided by MGI
Official Full Name
DnaJ heat shock protein family (Hsp40) member A1provided by MGI
Primary source
MGI:MGI:1270129
See related
Ensembl:ENSMUSG00000028410 AllianceGenome:MGI:1270129
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Hsj2; HSJ-2; Nedd7
Summary
The protein encoded by this gene is a member of the DnaJ family, whose members act as cochaperones of heat shock protein 70. Heat shock proteins facilitate protein folding, trafficking, prevention of aggregation, and proteolytic degradation. Members of this family are characterized by a highly conserved N-terminal J domain, a glycine/phenylalanine-rich region, four CxxCxGxG zinc finger repeats, and a C-terminal substrate-binding domain. The J domain mediates the interaction with heat shock protein 70 to recruit substrates and regulate ATP hydrolysis activity. Mice deficient for this gene display reduced levels of activation‐induced deaminase, an enzyme that deaminates deoxycytidine at the immunoglobulin genes during immune responses. In addition, mice lacking this gene exhibit severe defects in spermatogenesis. Several pseudogenes of this gene are found on other chromosomes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015]
Expression
Broad expression in CNS E11.5 (RPKM 48.9), CNS E14 (RPKM 41.5) and 19 other tissues See more
Orthologs
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Genomic context

See Dnaja1 in Genome Data Viewer
Location:
4; 4 A5
Exon count:
10
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (40722468..40734965)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (40722468..40734965)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 4933428C19 gene Neighboring gene aprataxin Neighboring gene predicted gene 6297 Neighboring gene microRNA 207 Neighboring gene smu-1 suppressor of mec-8 and unc-52 homolog (C. elegans) Neighboring gene presenilin enhancer gamma secretase subunit, pseudogene Neighboring gene predicted gene, 34213

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (3)  1 citation
  • Endonuclease-mediated (1) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables ATPase activator activity ISO
Inferred from Sequence Orthology
more info
 
enables C3HC4-type RING finger domain binding ISO
Inferred from Sequence Orthology
more info
 
enables G protein-coupled receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables Hsp70 protein binding ISO
Inferred from Sequence Orthology
more info
 
enables Tat protein binding ISO
Inferred from Sequence Orthology
more info
 
enables chaperone binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables chaperone binding ISO
Inferred from Sequence Orthology
more info
 
enables heat shock protein binding IEA
Inferred from Electronic Annotation
more info
 
enables low-density lipoprotein particle receptor binding ISO
Inferred from Sequence Orthology
more info
PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables ubiquitin protein ligase binding ISO
Inferred from Sequence Orthology
more info
 
enables unfolded protein binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within androgen receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within flagellated sperm motility IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of JUN kinase activity ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of establishment of protein localization to mitochondrion ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of nitrosative stress-induced intrinsic apoptotic signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of protein ubiquitination ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in protein folding IEA
Inferred from Electronic Annotation
more info
 
involved_in protein localization to mitochondrion ISO
Inferred from Sequence Orthology
more info
 
involved_in protein refolding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of protein transport ISO
Inferred from Sequence Orthology
more info
 
involved_in response to heat IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within spermatogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within toxin transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
 
located_in intracellular membrane-bounded organelle IEA
Inferred from Electronic Annotation
more info
 
located_in membrane ISO
Inferred from Sequence Orthology
more info
 
located_in microtubule cytoskeleton ISO
Inferred from Sequence Orthology
more info
 
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
dnaJ homolog subfamily A member 1
Names
DnaJ (Hsp40) homolog, subfamily A, member 1
dnaJ protein homolog 2
heat shock 40 kDa protein 4
heat shock protein J2
heat shock protein, Dnaj-like 2
neural precursor cell expressed, developmentally down-regulated gene 7

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001164671.2NP_001158143.1  dnaJ homolog subfamily A member 1

    See identical proteins and their annotated locations for NP_001158143.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    AK083046, AK145963, BP766105, BY245852, CN669546
    Consensus CDS
    CCDS18049.1
    UniProtKB/Swiss-Prot
    P54102, P63037
    UniProtKB/TrEMBL
    A0A6P5PJP6, A0A8C6GLX2, Q5NTY0
    Related
    ENSMUSP00000129730.2, ENSMUST00000164233.8
    Conserved Domains (1) summary
    PTZ00037
    Location:2394
    PTZ00037; DnaJ_C chaperone protein; Provisional
  2. NM_001164672.2NP_001158144.1  dnaJ homolog subfamily A member 1

    See identical proteins and their annotated locations for NP_001158144.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    AK083046, AK145963, BP766105, CK617936
    Consensus CDS
    CCDS18049.1
    UniProtKB/Swiss-Prot
    P54102, P63037
    UniProtKB/TrEMBL
    A0A6P5PJP6, A0A8C6GLX2, Q5NTY0
    Conserved Domains (1) summary
    PTZ00037
    Location:2394
    PTZ00037; DnaJ_C chaperone protein; Provisional
  3. NM_008298.6NP_032324.1  dnaJ homolog subfamily A member 1

    See identical proteins and their annotated locations for NP_032324.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    AK083046, AK145963, BB574002, BP766105
    Consensus CDS
    CCDS18049.1
    UniProtKB/Swiss-Prot
    P54102, P63037
    UniProtKB/TrEMBL
    A0A6P5PJP6, A0A8C6GLX2, Q5NTY0
    Related
    ENSMUSP00000030118.4, ENSMUST00000030118.10
    Conserved Domains (1) summary
    PTZ00037
    Location:2394
    PTZ00037; DnaJ_C chaperone protein; Provisional

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    40722468..40734965
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)