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IQUB IQ motif and ubiquitin domain containing [ Homo sapiens (human) ]

Gene ID: 154865, updated on 12-Aug-2022

Summary

Official Symbol
IQUBprovided by HGNC
Official Full Name
IQ motif and ubiquitin domain containingprovided by HGNC
Primary source
HGNC:HGNC:21995
See related
Ensembl:ENSG00000164675 AllianceGenome:HGNC:21995
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Predicted to be involved in cilium assembly. Predicted to act upstream of or within smoothened signaling pathway. Predicted to be active in acrosomal vesicle and motile cilium. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in testis (RPKM 8.0), thyroid (RPKM 0.9) and 1 other tissue See more
Orthologs
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Genomic context

See IQUB in Genome Data Viewer
Location:
7q31.32
Exon count:
19
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (123452193..123534595, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (124768955..124851361, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (123092247..123174649, complement)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene solute carrier family 13 member 1 Neighboring gene LYPLA1 pseudogene 1 Neighboring gene RNA, U6 small nuclear 296, pseudogene Neighboring gene uncharacterized LOC124901740 Neighboring gene NADH:ubiquinone oxidoreductase subunit A5 Neighboring gene Sharpr-MPRA regulatory region 8884 Neighboring gene ankyrin repeat and SOCS box containing 15 Neighboring gene ASB15 antisense RNA 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of IQ motif and ubiquitin domain containing (IQUB) by siRNA inhibits HIV-1 replication in HeLa-derived TZM-bl cells PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ35834, MGC149284, MGC149285

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in cilium assembly IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in smoothened signaling pathway IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in acrosomal vesicle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
is_active_in motile cilium IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
IQ and ubiquitin-like domain-containing protein

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001282855.2NP_001269784.1  IQ and ubiquitin-like domain-containing protein

    See identical proteins and their annotated locations for NP_001269784.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate promoter and differs in the 5' UTR compared to variant 1. Variants 1, 2, and 5 all encode the same protein.
    Source sequence(s)
    AI377787, BC036121
    Consensus CDS
    CCDS5787.1
    UniProtKB/Swiss-Prot
    Q8N9Y2, Q8NA54
    UniProtKB/TrEMBL
    A0A024R771
    Related
    ENSP00000417769.1, ENST00000466202.5
    Conserved Domains (1) summary
    cd01769
    Location:141200
    UBL; Ubiquitin-like domain of UBL
  2. NM_001321293.2NP_001308222.1  IQ and ubiquitin-like domain-containing protein

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) and variants 1 and 2 all encode the same protein.
    Source sequence(s)
    AC073323, BC036121, BC057256
    Consensus CDS
    CCDS5787.1
    UniProtKB/Swiss-Prot
    Q8N9Y2, Q8NA54
    UniProtKB/TrEMBL
    A0A024R771
    Conserved Domains (1) summary
    cd01769
    Location:141200
    UBL; Ubiquitin-like domain of UBL
  3. NM_178827.5NP_849149.3  IQ and ubiquitin-like domain-containing protein

    See identical proteins and their annotated locations for NP_849149.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the predominant transcript. Variants 1, 2, and 5 all encode the same protein.
    Source sequence(s)
    AC073323, BC128181, DA112303
    Consensus CDS
    CCDS5787.1
    UniProtKB/Swiss-Prot
    Q8N9Y2, Q8NA54
    UniProtKB/TrEMBL
    A0A024R771
    Related
    ENSP00000324882.6, ENST00000324698.11
    Conserved Domains (1) summary
    cd01769
    Location:141200
    UBL; Ubiquitin-like domain of UBL

RNA

  1. NR_104244.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate promoter and contains an additional exon in the 3' region compared to variant 1. This variant is represented as non-coding because the use of the 5'-most translational start codon, as used in variant 1, renders this transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AI377787, BC026173, BC036121
    Related
    ENST00000484508.5
  2. NR_104245.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) lacks an exon in the mid region compared to variant 1. This variant is represented as non-coding because the use of the 5'-most translational start codon, as used in variant 1, renders this transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AI377787, BC036121, BC128182, DA112303
    Related
    ENST00000469057.1

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

    Range
    123452193..123534595 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017011772.3XP_016867261.1  IQ and ubiquitin-like domain-containing protein isoform X3

  2. XM_011515834.4XP_011514136.1  IQ and ubiquitin-like domain-containing protein isoform X1

    See identical proteins and their annotated locations for XP_011514136.1

    UniProtKB/Swiss-Prot
    Q8N9Y2, Q8NA54
    UniProtKB/TrEMBL
    A0A024R771
    Conserved Domains (1) summary
    cd01769
    Location:141200
    UBL; Ubiquitin-like domain of UBL
  3. XM_011515833.3XP_011514135.1  IQ and ubiquitin-like domain-containing protein isoform X1

    See identical proteins and their annotated locations for XP_011514135.1

    UniProtKB/Swiss-Prot
    Q8N9Y2, Q8NA54
    UniProtKB/TrEMBL
    A0A024R771
    Conserved Domains (1) summary
    cd01769
    Location:141200
    UBL; Ubiquitin-like domain of UBL
  4. XM_017011771.2XP_016867260.1  IQ and ubiquitin-like domain-containing protein isoform X1

    UniProtKB/Swiss-Prot
    Q8N9Y2, Q8NA54
    UniProtKB/TrEMBL
    A0A024R771
    Conserved Domains (1) summary
    cd01769
    Location:141200
    UBL; Ubiquitin-like domain of UBL
  5. XM_047419924.1XP_047275880.1  IQ and ubiquitin-like domain-containing protein isoform X1

    UniProtKB/Swiss-Prot
    Q8N9Y2
    UniProtKB/TrEMBL
    A0A024R771
  6. XM_005250161.4XP_005250218.1  IQ and ubiquitin-like domain-containing protein isoform X1

    See identical proteins and their annotated locations for XP_005250218.1

    UniProtKB/Swiss-Prot
    Q8N9Y2, Q8NA54
    UniProtKB/TrEMBL
    A0A024R771
    Conserved Domains (1) summary
    cd01769
    Location:141200
    UBL; Ubiquitin-like domain of UBL
  7. XM_005250162.6XP_005250219.1  IQ and ubiquitin-like domain-containing protein isoform X2

    Conserved Domains (1) summary
    cd01769
    Location:141200
    UBL; Ubiquitin-like domain of UBL

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060931.1 Alternate T2T-CHM13v2.0

    Range
    124768955..124851361 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)