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Hspa1l heat shock protein 1-like [ Mus musculus (house mouse) ]

Gene ID: 15482, updated on 9-Dec-2024

Summary

Official Symbol
Hspa1lprovided by MGI
Official Full Name
heat shock protein 1-likeprovided by MGI
Primary source
MGI:MGI:96231
See related
Ensembl:ENSMUSG00000007033 AllianceGenome:MGI:96231
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Msh5; Hsc70t
Summary
Predicted to enable several functions, including ATP hydrolysis activity; ubiquitin protein ligase binding activity; and unfolded protein binding activity. Acts upstream of or within binding activity of sperm to zona pellucida. Located in cell body. Part of zona pellucida receptor complex. Is expressed in several structures, including alimentary system; brain; genitourinary system; integumental system; and limb segment. Human ortholog(s) of this gene implicated in Kawasaki disease; major depressive disorder; schizophrenia; systemic lupus erythematosus; and uveitis. Orthologous to human HSPA1L (heat shock protein family A (Hsp70) member 1 like). [provided by Alliance of Genome Resources, Dec 2024]
Expression
Biased expression in testis adult (RPKM 320.0) and ovary adult (RPKM 8.9) See more
Orthologs
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Genomic context

See Hspa1l in Genome Data Viewer
Location:
17 B1; 17 18.51 cM
Exon count:
2
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (35191679..35198204)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (34972703..34979228)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E5598 Neighboring gene heat shock protein 1B Neighboring gene heat shock protein 1A Neighboring gene LSM2 homolog, U6 small nuclear RNA and mRNA degradation associated Neighboring gene DNA segment, Chr 17, human D6S56E 5 Neighboring gene STARR-positive B cell enhancer ABC_E1941

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1)  1 citation
  • Targeted (2) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • MGC150263, MGC150264

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables ATP hydrolysis activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables ATP-dependent protein folding chaperone IEA
Inferred from Electronic Annotation
more info
 
enables heat shock protein binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables heat shock protein binding IEA
Inferred from Electronic Annotation
more info
 
enables heat shock protein binding ISO
Inferred from Sequence Orthology
more info
 
enables protein folding chaperone IBA
Inferred from Biological aspect of Ancestor
more info
 
enables ubiquitin protein ligase binding IEA
Inferred from Electronic Annotation
more info
 
enables ubiquitin protein ligase binding ISO
Inferred from Sequence Orthology
more info
 
enables unfolded protein binding IEA
Inferred from Electronic Annotation
more info
 
enables unfolded protein binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within binding of sperm to zona pellucida IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cell differentiation IEA
Inferred from Electronic Annotation
more info
 
involved_in chaperone cofactor-dependent protein refolding IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in positive regulation of protein targeting to mitochondrion IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of protein targeting to mitochondrion ISO
Inferred from Sequence Orthology
more info
 
involved_in protein refolding IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in protein refolding IEA
Inferred from Electronic Annotation
more info
 
involved_in protein refolding ISO
Inferred from Sequence Orthology
more info
 
involved_in spermatogenesis IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
part_of COP9 signalosome IEA
Inferred from Electronic Annotation
more info
 
part_of COP9 signalosome ISO
Inferred from Sequence Orthology
more info
 
located_in cell body IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytosol IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in mitochondrial matrix IEA
Inferred from Electronic Annotation
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of zona pellucida receptor complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
heat shock 70 kDa protein 1-like
Names
heat shock 70 kDa protein 1L
heat shock 70 kDa-like protein 1
heat shock 70kDa protein 1-like
heat shock protein cognate 70, testis
heat shock-related protein hsc70t
inducible heat shock protein 70
spermatid-specific heat shock protein 70

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_013558.2NP_038586.2  heat shock 70 kDa protein 1-like

    See identical proteins and their annotated locations for NP_038586.2

    Status: VALIDATED

    Source sequence(s)
    AC087117, BC129895, BY099756
    Consensus CDS
    CCDS28670.1
    UniProtKB/Swiss-Prot
    O88686, P16627, Q61693
    UniProtKB/TrEMBL
    A1L347, B2CSK2
    Related
    ENSMUSP00000007248.4, ENSMUST00000007248.5
    Conserved Domains (1) summary
    cl26953
    Location:3641
    HSP70; Hsp70 protein

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    35191679..35198204
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)