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CYP1A1 cytochrome P450 family 1 subfamily A member 1 [ Homo sapiens (human) ]

Gene ID: 1543, updated on 11-Jun-2021

Summary

Official Symbol
CYP1A1provided by HGNC
Official Full Name
cytochrome P450 family 1 subfamily A member 1provided by HGNC
Primary source
HGNC:HGNC:2595
See related
Ensembl:ENSG00000140465 MIM:108330
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
AHH; AHRR; CP11; CYP1; CYPIA1; P1-450; P450-C; P450DX
Summary
This gene, CYP1A1, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by some polycyclic aromatic hydrocarbons (PAHs), some of which are found in cigarette smoke. The enzyme's endogenous substrate is unknown; however, it is able to metabolize some PAHs to carcinogenic intermediates. The gene has been associated with lung cancer risk. A related family member, CYP1A2, is located approximately 25 kb away from CYP1A1 on chromosome 15. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jan 2016]
Expression
Biased expression in urinary bladder (RPKM 40.8), liver (RPKM 18.0) and 1 other tissue See more
Orthologs
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Genomic context

See CYP1A1 in Genome Data Viewer
Location:
15q24.1
Exon count:
7
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 15 NC_000015.10 (74719542..74725528, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (75011883..75017869, complement)

Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102723750 Neighboring gene CDC like kinase 3 Neighboring gene enhancer of mRNA decapping 3 Neighboring gene CYP1A1 5' regulatory region Neighboring gene CYP1A2 5' regulatory region Neighboring gene enhancer downstream of CYP1A2 Neighboring gene cytochrome P450 family 1 subfamily A member 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk.
GeneReviews: Not available
Genome-wide association analysis of coffee drinking suggests association with CYP1A1/CYP1A2 and NRCAM.
GeneReviews: Not available
Genome-wide association study identifies eight loci associated with blood pressure.
GeneReviews: Not available
Genome-wide meta-analysis identifies regions on 7p21 (AHR) and 15q24 (CYP1A2) as determinants of habitual caffeine consumption.
GeneReviews: Not available
Genome-wide meta-analysis identifies six novel loci associated with habitual coffee consumption.
GeneReviews: Not available
Sequence variants at CYP1A1-CYP1A2 and AHR associate with coffee consumption.
GeneReviews: Not available

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables Hsp70 protein binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables Hsp90 protein binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables arachidonic acid monooxygenase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables aromatase activity IEA
Inferred from Electronic Annotation
more info
 
enables demethylase activity IEA
Inferred from Electronic Annotation
more info
 
enables enzyme binding IEA
Inferred from Electronic Annotation
more info
 
enables estrogen 16-alpha-hydroxylase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables estrogen 2-hydroxylase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables flavonoid 3'-monooxygenase activity IEA
Inferred from Electronic Annotation
more info
 
enables heme binding IEA
Inferred from Electronic Annotation
more info
 
enables hydroperoxy icosatetraenoate dehydratase activity IEA
Inferred from Electronic Annotation
more info
 
enables iron ion binding IEA
Inferred from Electronic Annotation
more info
 
enables monooxygenase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables oxidoreductase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables oxidoreductase activity, acting on diphenols and related substances as donors IEA
Inferred from Electronic Annotation
more info
 
enables oxygen binding TAS
Traceable Author Statement
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables vitamin D 24-hydroxylase activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
involved_in 9-cis-retinoic acid biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
involved_in DNA methylation IEA
Inferred from Electronic Annotation
more info
 
involved_in aging IEA
Inferred from Electronic Annotation
more info
 
involved_in amine metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in camera-type eye development IEA
Inferred from Electronic Annotation
more info
 
involved_in cell population proliferation IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular response to copper ion IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within cellular response to organic cyclic compound IDA
Inferred from Direct Assay
more info
PubMed 
involved_in coumarin metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in demethylation IEA
Inferred from Electronic Annotation
more info
 
involved_in dibenzo-p-dioxin catabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in digestive tract development IEA
Inferred from Electronic Annotation
more info
 
involved_in drug metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in epoxygenase P450 pathway TAS
Traceable Author Statement
more info
 
involved_in estrogen metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in ethylene metabolic process TAS
Traceable Author Statement
more info
 
involved_in fatty acid metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in flavonoid metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in hepatocyte differentiation IEA
Inferred from Electronic Annotation
more info
 
involved_in hydrogen peroxide biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
involved_in insecticide metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in lipid hydroxylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in long-chain fatty acid biosynthetic process TAS
Traceable Author Statement
more info
 
involved_in maternal process involved in parturition IEA
Inferred from Electronic Annotation
more info
 
involved_in omega-hydroxylase P450 pathway TAS
Traceable Author Statement
more info
 
involved_in porphyrin-containing compound metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of G1/S transition of mitotic cell cycle IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of metabolic process TAS
Traceable Author Statement
more info
 
involved_in response to antibiotic IEA
Inferred from Electronic Annotation
more info
 
involved_in response to arsenic-containing substance IEA
Inferred from Electronic Annotation
more info
 
involved_in response to drug IEA
Inferred from Electronic Annotation
more info
 
involved_in response to food IEA
Inferred from Electronic Annotation
more info
 
involved_in response to herbicide IEA
Inferred from Electronic Annotation
more info
 
involved_in response to hyperoxia IEA
Inferred from Electronic Annotation
more info
 
involved_in response to hypoxia IEA
Inferred from Electronic Annotation
more info
 
involved_in response to immobilization stress IEA
Inferred from Electronic Annotation
more info
 
involved_in response to iron(III) ion IEA
Inferred from Electronic Annotation
more info
 
involved_in response to lipopolysaccharide IEA
Inferred from Electronic Annotation
more info
 
involved_in response to nematode IEA
Inferred from Electronic Annotation
more info
 
involved_in response to virus IEA
Inferred from Electronic Annotation
more info
 
involved_in response to vitamin A IEA
Inferred from Electronic Annotation
more info
 
involved_in response to wounding IEA
Inferred from Electronic Annotation
more info
 
involved_in retinol metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in retinol metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in steroid biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
involved_in steroid metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in vitamin D metabolic process IC
Inferred by Curator
more info
PubMed 
Component Evidence Code Pubs
located_in endoplasmic reticulum membrane TAS
Traceable Author Statement
more info
 
is_active_in intracellular membrane-bounded organelle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in mitochondrial inner membrane ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
cytochrome P450 1A1
Names
aryl hydrocarbon hydroxylase
cytochrome P1-450, dioxin-inducible
cytochrome P450 form 6
cytochrome P450, family 1, subfamily A, polypeptide 1
cytochrome P450, subfamily I (aromatic compound-inducible), polypeptide 1
cytochrome P450-C
cytochrome P450-P1
flavoprotein-linked monooxygenase
hydroperoxy icosatetraenoate dehydratase
xenobiotic monooxygenase
NP_000490.1
NP_001306145.1
NP_001306146.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_061374.1 RefSeqGene

    Range
    5001..10987
    Download
    GenBank, FASTA, Sequence Viewer (Graphics), LRG_1262

mRNA and Protein(s)

  1. NM_000499.5NP_000490.1  cytochrome P450 1A1 isoform 1

    See identical proteins and their annotated locations for NP_000490.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1). Variants 1 and 3 encode the same isoform (1).
    Source sequence(s)
    AC091230
    Consensus CDS
    CCDS10268.1
    UniProtKB/Swiss-Prot
    P04798
    UniProtKB/TrEMBL
    A0N0X8
    Related
    ENSP00000378488.2, ENST00000395048.6
    Conserved Domains (1) summary
    pfam00067
    Location:40499
    p450; Cytochrome P450
  2. NM_001319216.2NP_001306145.1  cytochrome P450 1A1 isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and lacks an in-frame coding exon, compared to variant 1, and encodes a shorter isoform (2), compared to isoform 1.
    Source sequence(s)
    AC091230
    Consensus CDS
    CCDS81906.1
    UniProtKB/Swiss-Prot
    P04798
    UniProtKB/TrEMBL
    E7EMT5
    Related
    ENSP00000378489.4, ENST00000395049.8
    Conserved Domains (1) summary
    pfam00067
    Location:40464
    p450; Cytochrome P450
  3. NM_001319217.2NP_001306146.1  cytochrome P450 1A1 isoform 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, compared to variant 1, and encodes isoform 1. Variants 1 and 3 encode the same isoform (1).
    Source sequence(s)
    AK223108, BC023019
    Consensus CDS
    CCDS10268.1
    UniProtKB/Swiss-Prot
    P04798
    UniProtKB/TrEMBL
    A0N0X8
    Related
    ENSP00000369050.3, ENST00000379727.8
    Conserved Domains (1) summary
    pfam00067
    Location:40499
    p450; Cytochrome P450

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000015.10 Reference GRCh38.p13 Primary Assembly

    Range
    74719542..74725528 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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