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Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 [ Mus musculus (house mouse) ]

Gene ID: 13076, updated on 1-Mar-2024

Summary

Official Symbol
Cyp1a1provided by MGI
Official Full Name
cytochrome P450, family 1, subfamily a, polypeptide 1provided by MGI
Primary source
MGI:MGI:88588
See related
Ensembl:ENSMUSG00000032315 AllianceGenome:MGI:88588
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
AHH; AHRR; CP11; CYPIA1; P450-1
Summary
Enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen. Acts upstream of or within several processes, including hydrogen peroxide biosynthetic process; response to toxic substance; and toxin metabolic process. Predicted to be located in mitochondrial inner membrane. Predicted to be active in intracellular membrane-bounded organelle. Is expressed in several structures, including genitourinary system; liver; maxillary process; spleen; and upper jaw. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); diabetes mellitus (multiple); gastrointestinal system cancer (multiple); hematologic cancer (multiple); and lung disease (multiple). Orthologous to human CYP1A1 (cytochrome P450 family 1 subfamily A member 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in liver adult (RPKM 18.0), lung adult (RPKM 13.7) and 2 other tissues See more
Orthologs
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Genomic context

See Cyp1a1 in Genome Data Viewer
Location:
9 B; 9 31.34 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (57595211..57611107)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (57687928..57703824)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E9763 Neighboring gene c-src tyrosine kinase Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:57498764-57498965 Neighboring gene Cyp1a2 5' enhancer Neighboring gene cytochrome P450, family 1, subfamily a, polypeptide 2 Neighboring gene Cyp1a1 5' regulatory region Neighboring gene enhancer of mRNA decapping 3 Neighboring gene STARR-positive B cell enhancer ABC_E11409 Neighboring gene CDC-like kinase 3 Neighboring gene CapStarr-seq enhancers MGSCv37_chr9:57617333-57617516 and MGSCv37_chr9:57617555-57617846 Neighboring gene predicted gene, 32510

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (8)  1 citation
  • Endonuclease-mediated (4) 

Pathways from PubChem

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables Hsp70 protein binding ISO
Inferred from Sequence Orthology
more info
 
enables Hsp90 protein binding ISO
Inferred from Sequence Orthology
more info
 
enables arachidonic acid monooxygenase activity ISO
Inferred from Sequence Orthology
more info
 
enables aromatase activity IEA
Inferred from Electronic Annotation
more info
 
enables catalytic activity ISO
Inferred from Sequence Orthology
more info
 
enables demethylase activity ISO
Inferred from Sequence Orthology
more info
 
enables enzyme binding ISO
Inferred from Sequence Orthology
more info
 
enables estrogen 16-alpha-hydroxylase activity ISO
Inferred from Sequence Orthology
more info
 
enables estrogen 2-hydroxylase activity ISO
Inferred from Sequence Orthology
more info
 
enables flavonoid 3'-monooxygenase activity ISO
Inferred from Sequence Orthology
more info
 
enables heme binding IEA
Inferred from Electronic Annotation
more info
 
enables hydroperoxy icosatetraenoate dehydratase activity IEA
Inferred from Electronic Annotation
more info
 
enables iron ion binding IEA
Inferred from Electronic Annotation
more info
 
enables long-chain fatty acid omega-1 hydroxylase activity ISO
Inferred from Sequence Orthology
more info
 
enables long-chain fatty acid omega-hydroxylase activity ISO
Inferred from Sequence Orthology
more info
 
enables lyase activity IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables monooxygenase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables monooxygenase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables monooxygenase activity ISO
Inferred from Sequence Orthology
more info
 
contributes_to oxidoreductase activity ISO
Inferred from Sequence Orthology
more info
 
enables oxidoreductase activity ISO
Inferred from Sequence Orthology
more info
 
enables oxidoreductase activity, acting on diphenols and related substances as donors ISO
Inferred from Sequence Orthology
more info
 
enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen IEA
Inferred from Electronic Annotation
more info
 
enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen IDA
Inferred from Direct Assay
more info
PubMed 
enables steroid hydroxylase activity ISO
Inferred from Sequence Orthology
more info
 
enables vitamin D 24-hydroxylase activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in 9-cis-retinoic acid biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within amine metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within cellular response to organic cyclic compound ISO
Inferred from Sequence Orthology
more info
PubMed 
involved_in coumarin metabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in dibenzo-p-dioxin catabolic process ISO
Inferred from Sequence Orthology
more info
 
NOT acts_upstream_of_or_within dibenzo-p-dioxin metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in estrogen metabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in fatty acid metabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in flavonoid metabolic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within heterocycle metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within hydrogen peroxide biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in insecticide metabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in lipid hydroxylation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within lipid metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in long-chain fatty acid metabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in porphyrin-containing compound metabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of G1/S transition of mitotic cell cycle ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within response to toxic substance IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in retinol metabolic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within steroid biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
involved_in steroid metabolic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within toxin metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in xenobiotic metabolic process ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
 
is_active_in intracellular membrane-bounded organelle IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in intracellular membrane-bounded organelle IEA
Inferred from Electronic Annotation
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in mitochondrial inner membrane ISO
Inferred from Sequence Orthology
more info
 
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
cytochrome P450 1A1
Names
cytochrome P450 form 6
cytochrome P450 subfamily I, polypeptide 1
cytochrome P450, 1a1, aromatic compound inducible
cytochrome P450-C
cytochrome P450-P1
hydroperoxy icosatetraenoate dehydratase
NP_001129531.1
NP_034122.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001136059.2NP_001129531.1  cytochrome P450 1A1

    See identical proteins and their annotated locations for NP_001129531.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) contains an alternate 5' non-coding exon compared to variant 1. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AW110759, Y00071
    Consensus CDS
    CCDS23230.1
    UniProtKB/Swiss-Prot
    P00184, Q61455
    UniProtKB/TrEMBL
    Q05A20
    Related
    ENSMUSP00000034865.5, ENSMUST00000034865.6
    Conserved Domains (1) summary
    pfam00067
    Location:44503
    p450; Cytochrome P450
  2. NM_009992.4NP_034122.1  cytochrome P450 1A1

    See identical proteins and their annotated locations for NP_034122.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AK005000, AW110759
    Consensus CDS
    CCDS23230.1
    UniProtKB/Swiss-Prot
    P00184, Q61455
    UniProtKB/TrEMBL
    Q05A20
    Related
    ENSMUSP00000150277.2, ENSMUST00000216433.2
    Conserved Domains (1) summary
    pfam00067
    Location:44503
    p450; Cytochrome P450

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    57595211..57611107
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)