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TTC23L tetratricopeptide repeat domain 23 like [ Homo sapiens (human) ]

Gene ID: 153657, updated on 11-Jun-2021

Summary

Official Symbol
TTC23Lprovided by HGNC
Official Full Name
tetratricopeptide repeat domain 23 likeprovided by HGNC
Primary source
HGNC:HGNC:26355
See related
Ensembl:ENSG00000205838 MIM:616344
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MC25-1
Expression
Biased expression in testis (RPKM 3.3), adrenal (RPKM 0.3) and 2 other tissues See more
Orthologs
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Genomic context

See TTC23L in Genome Data Viewer
Location:
5p13.2
Exon count:
27
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 5 NC_000005.10 (34839164..34925682)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (34839269..34925787)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105374723 Neighboring gene retinoic acid induced 14 Neighboring gene TTC23L antisense RNA 1 Neighboring gene ribosomal protein L21 pseudogene 54 Neighboring gene RAD1 checkpoint DNA exonuclease Neighboring gene biogenesis of ribosomes BRX1 Neighboring gene DnaJ heat shock protein family (Hsp40) member C21 Neighboring gene alanine--glyoxylate aminotransferase 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of tetratricopeptide repeat domain 23-like (TTC23L) by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ25439

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in response to endoplasmic reticulum stress NAS
Non-traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in microtubule organizing center IEA
Inferred from Electronic Annotation
more info
 
located_in midbody IEA
Inferred from Electronic Annotation
more info
 
located_in spindle IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
tetratricopeptide repeat protein 23-like

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001317949.2NP_001304878.1  tetratricopeptide repeat protein 23-like isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC026801, JN799997
    UniProtKB/Swiss-Prot
    Q6PF05
    Conserved Domains (1) summary
    pfam13424
    Location:262341
    TPR_12; Tetratricopeptide repeat
  2. NM_001386169.1NP_001373098.1  tetratricopeptide repeat protein 23-like isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC026801
    Related
    ENSP00000491000.1, ENST00000638320.2
  3. NM_001386170.1NP_001373099.1  tetratricopeptide repeat protein 23-like isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC026801
  4. NM_001386171.1NP_001373100.1  tetratricopeptide repeat protein 23-like isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC026801
  5. NM_001386172.1NP_001373101.1  tetratricopeptide repeat protein 23-like isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC026801
  6. NM_144725.4NP_653326.3  tetratricopeptide repeat protein 23-like isoform 2

    See identical proteins and their annotated locations for NP_653326.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, initiates translation at a downstream start site, and contains a shorter 3' UTR, compared to variant 1. The encoded isoform (2) has a shorter N-terminus than isoform 1.
    Source sequence(s)
    AC026801, AK058168, BC057775, BX088767
    Consensus CDS
    CCDS54840.1
    UniProtKB/Swiss-Prot
    Q6PF05
    Related
    ENSP00000422188.1, ENST00000505624.5
    Conserved Domains (1) summary
    pfam13424
    Location:253332
    TPR_12; Tetratricopeptide repeat

RNA

  1. NR_169874.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC026801
  2. NR_169875.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC026801
  3. NR_169876.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC026801

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p13 Primary Assembly

    Range
    34839164..34925682
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011513984.3XP_011512286.1  tetratricopeptide repeat protein 23-like isoform X1

    Related
    ENSP00000497109.1, ENST00000514080.2
    Conserved Domains (1) summary
    pfam13424
    Location:253332
    TPR_12; Tetratricopeptide repeat
  2. XM_011513985.2XP_011512287.1  tetratricopeptide repeat protein 23-like isoform X3

    Conserved Domains (1) summary
    pfam13424
    Location:253332
    TPR_12; Tetratricopeptide repeat
  3. XM_017009123.2XP_016864612.1  tetratricopeptide repeat protein 23-like isoform X4

  4. XM_011513987.3XP_011512289.1  tetratricopeptide repeat protein 23-like isoform X6

    Related
    ENSP00000484792.1, ENST00000610313.1
  5. XM_017009120.2XP_016864609.1  tetratricopeptide repeat protein 23-like isoform X1

    Conserved Domains (1) summary
    pfam13424
    Location:253332
    TPR_12; Tetratricopeptide repeat
  6. XM_017009121.2XP_016864610.1  tetratricopeptide repeat protein 23-like isoform X1

    Conserved Domains (1) summary
    pfam13424
    Location:253332
    TPR_12; Tetratricopeptide repeat
  7. XM_017009125.1XP_016864614.1  tetratricopeptide repeat protein 23-like isoform X7

  8. XM_017009124.2XP_016864613.1  tetratricopeptide repeat protein 23-like isoform X5

  9. XM_017009126.2XP_016864615.1  tetratricopeptide repeat protein 23-like isoform X7

  10. XM_017009119.2XP_016864608.1  tetratricopeptide repeat protein 23-like isoform X2

  11. XM_017009122.2XP_016864611.1  tetratricopeptide repeat protein 23-like isoform X1

    Conserved Domains (1) summary
    pfam13424
    Location:253332
    TPR_12; Tetratricopeptide repeat
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