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KLB klotho beta [ Homo sapiens (human) ]

Gene ID: 152831, updated on 4-Jun-2020

Summary

Official Symbol
KLBprovided by HGNC
Official Full Name
klotho betaprovided by HGNC
Primary source
HGNC:HGNC:15527
See related
Ensembl:ENSG00000134962 MIM:611135
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
BKL
Expression
Biased expression in fat (RPKM 16.3), liver (RPKM 5.1) and 2 other tissues See more
Orthologs

Genomic context

See KLB in Genome Data Viewer
Location:
4p14
Exon count:
5
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 4 NC_000004.12 (39406930..39451533)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (39408473..39453153)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene RNA, U6 small nuclear 32, pseudogene Neighboring gene replication factor C subunit 1 Neighboring gene RNA, U6 small nuclear 887, pseudogene Neighboring gene microRNA 5591 Neighboring gene Sharpr-MPRA regulatory region 11886 Neighboring gene ribosomal protein L9 Neighboring gene lipoic acid synthetase

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC142213

Gene Ontology Provided by GOA

Function Evidence Code Pubs
fibroblast growth factor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
fibroblast growth factor binding IPI
Inferred from Physical Interaction
more info
PubMed 
fibroblast growth factor receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
fibroblast growth factor receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
hydrolase activity, hydrolyzing O-glycosyl compounds IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
MAPK cascade TAS
Traceable Author Statement
more info
 
carbohydrate metabolic process IEA
Inferred from Electronic Annotation
more info
 
fibroblast growth factor receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
fibroblast growth factor receptor signaling pathway TAS
Traceable Author Statement
more info
 
positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
positive regulation of cell proliferation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of protein kinase B signaling TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
beta-klotho
Names
b-Klotho
betaKlotho
klotho beta like
klotho beta-like protein

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_175737.4NP_783864.1  beta-klotho

    See identical proteins and their annotated locations for NP_783864.1

    Status: VALIDATED

    Source sequence(s)
    AB079373, AC021148, AK302436, BJ993426
    Consensus CDS
    CCDS3451.1
    UniProtKB/Swiss-Prot
    Q86Z14
    UniProtKB/TrEMBL
    B4DYH5
    Related
    ENSP00000257408.4, ENST00000257408.5
    Conserved Domains (1) summary
    cl23725
    Location:77508
    Glyco_hydro_1; Glycosyl hydrolase family 1

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p13 Primary Assembly

    Range
    39406930..39451533
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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