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NFXL1 nuclear transcription factor, X-box binding like 1 [ Homo sapiens (human) ]

Gene ID: 152518, updated on 10-Dec-2019

Summary

Official Symbol
NFXL1provided by HGNC
Official Full Name
nuclear transcription factor, X-box binding like 1provided by HGNC
Primary source
HGNC:HGNC:18726
See related
Ensembl:ENSG00000170448
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
OZFP; CDZFP; HOZFP; URCC5
Expression
Broad expression in testis (RPKM 11.1), thyroid (RPKM 5.9) and 25 other tissues See more
Orthologs

Genomic context

See NFXL1 in Genome Data Viewer
Location:
4p12
Exon count:
25
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 4 NC_000004.12 (47847233..47914667, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (47849250..47916684, complement)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene corin, serine peptidase Neighboring gene ribosomal protein L15 pseudogene 7 Neighboring gene VISTA enhancer hs2414 Neighboring gene uncharacterized LOC101927179 Neighboring gene uncharacterized LOC101927157 Neighboring gene cyclic nucleotide gated channel subunit alpha 1 Neighboring gene NIPA like domain containing 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Potential readthrough

Included gene: CORIN

Homology

Clone Names

  • FLJ16294

Gene Ontology Provided by GOA

Process Evidence Code Pubs
regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 
regulation of transcription, DNA-templated IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
membrane HDA PubMed 
nuclear chromatin ISA
Inferred from Sequence Alignment
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
NF-X1-type zinc finger protein NFXL1
Names
cytoplasm-distribution zinc finger protein
ovarian zinc finger protein
up-regulated in colon cancer 5

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001278623.1NP_001265552.1  NF-X1-type zinc finger protein NFXL1

    See identical proteins and their annotated locations for NP_001265552.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    AB085695, AC107068
    Consensus CDS
    CCDS3478.2
    UniProtKB/Swiss-Prot
    Q6ZNB6
    UniProtKB/TrEMBL
    B1Q2B0
    Related
    ENSP00000333113.4, ENST00000329043.7
    Conserved Domains (1) summary
    cd06008
    Location:414462
    NF-X1-zinc-finger; Presumably a zinc binding domain, which has been shown to bind to DNA in the human nuclear transcriptional repressor NF-X1. The zinc finger can be characterized by the pattern C-X(1-6)-H-X-C-X3-C(H/C)-X(3-4)-(H/C)-X(1-10)-C. The NF-X1 zinc finger ...
  2. NM_001278624.2NP_001265553.1  NF-X1-type zinc finger protein NFXL1

    See identical proteins and their annotated locations for NP_001265553.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    AB181916, AC107068, DA801937
    Consensus CDS
    CCDS3478.2
    UniProtKB/Swiss-Prot
    Q6ZNB6
    Related
    ENSP00000422037.1, ENST00000507489.2
    Conserved Domains (1) summary
    cd06008
    Location:414462
    NF-X1-zinc-finger; Presumably a zinc binding domain, which has been shown to bind to DNA in the human nuclear transcriptional repressor NF-X1. The zinc finger can be characterized by the pattern C-X(1-6)-H-X-C-X3-C(H/C)-X(3-4)-(H/C)-X(1-10)-C. The NF-X1 zinc finger ...
  3. NM_152995.5NP_694540.3  NF-X1-type zinc finger protein NFXL1

    See identical proteins and their annotated locations for NP_694540.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the functional protein. Variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    AC107068, AK131285, BC040151, DB087408
    Consensus CDS
    CCDS3478.2
    UniProtKB/Swiss-Prot
    Q6ZNB6
    Related
    ENSP00000370949.3, ENST00000381538.7
    Conserved Domains (1) summary
    cd06008
    Location:414462
    NF-X1-zinc-finger; Presumably a zinc binding domain, which has been shown to bind to DNA in the human nuclear transcriptional repressor NF-X1. The zinc finger can be characterized by the pattern C-X(1-6)-H-X-C-X3-C(H/C)-X(3-4)-(H/C)-X(1-10)-C. The NF-X1 zinc finger ...

RNA

  1. NR_103795.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' most exon and use an alternate internal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC107068, BC051193
    Related
    ENST00000464756.6

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p13 Primary Assembly

    Range
    47847233..47914667 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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