Format

Send to:

Choose Destination

CORIN corin, serine peptidase [ Homo sapiens (human) ]

Gene ID: 10699, updated on 25-Nov-2019

Summary

Official Symbol
CORINprovided by HGNC
Official Full Name
corin, serine peptidaseprovided by HGNC
Primary source
HGNC:HGNC:19012
See related
Ensembl:ENSG00000145244 MIM:605236
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CRN; ATC2; Lrp4; PEE5; TMPRSS10
Summary
This gene encodes a member of the type II transmembrane serine protease class of the trypsin superfamily. Members of this family are composed of multiple structurally distinct domains. The encoded protein converts pro-atrial natriuretic peptide to biologically active atrial natriuretic peptide, a cardiac hormone that regulates blood volume and pressure. This protein may also function as a pro-brain-type natriuretic peptide convertase. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2013]
Expression
Biased expression in heart (RPKM 20.5), skin (RPKM 3.4) and 2 other tissues See more
Orthologs

Genomic context

See CORIN in Genome Data Viewer
Location:
4p12
Exon count:
22
Annotation release Status Assembly Chr Location
109.20190905 current GRCh38.p13 (GCF_000001405.39) 4 NC_000004.12 (47593998..47838106, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (47596015..47840395, complement)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107986277 Neighboring gene ribosomal protein L21 pseudogene 52 Neighboring gene ATPase phospholipid transporting 10D (putative) Neighboring gene uncharacterized LOC105374444 Neighboring gene uncharacterized LOC105374443 Neighboring gene microRNA 8053 Neighboring gene ribosomal protein L15 pseudogene 7 Neighboring gene VISTA enhancer hs2414 Neighboring gene uncharacterized LOC101927179 Neighboring gene nuclear transcription factor, X-box binding like 1 Neighboring gene uncharacterized LOC101927157 Neighboring gene cyclic nucleotide gated channel subunit alpha 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of corin, serine peptidase (CORIN) by shRNA library screening inhibits HIV-1 replication in cultured Jurkat T-cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

  • Cardiac conduction, organism-specific biosystem (from REACTOME)
    Cardiac conduction, organism-specific biosystemThe normal sequence of contraction of atria and ventricles of the heart require activation of groups of cardiac cells. The mechanism must elicit rapid changes in heart rate and respond to changes in ...
  • Muscle contraction, organism-specific biosystem (from REACTOME)
    Muscle contraction, organism-specific biosystemIn this module, the processes by which calcium binding triggers actin - myosin interactions and force generation in smooth and striated muscle tissues are annotated.
  • Myometrial Relaxation and Contraction Pathways, organism-specific biosystem (from WikiPathways)
    Myometrial Relaxation and Contraction Pathways, organism-specific biosystemThis pathway illustrates signaling networks implicated in uterine muscle contraction at labor and quiescence throughout gestation (pregnancy). The muscle of the uterus, responsible for contractile ac...
  • Physiological factors, organism-specific biosystem (from REACTOME)
    Physiological factors, organism-specific biosystemCardiovascular homeostasis can be regulated by natriuretic peptides (Pandey 2014).

General gene information

Markers

Potential readthrough

Included gene: NFXL1

Homology

Clone Names

  • MGC119742

Gene Ontology Provided by GOA

Function Evidence Code Pubs
serine-type endopeptidase activity IDA
Inferred from Direct Assay
more info
PubMed 
serine-type endopeptidase activity TAS
Traceable Author Statement
more info
 
Process Evidence Code Pubs
female pregnancy IMP
Inferred from Mutant Phenotype
more info
PubMed 
peptide hormone processing IDA
Inferred from Direct Assay
more info
PubMed 
regulation of blood pressure ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of cardiac conduction TAS
Traceable Author Statement
more info
 
regulation of renal sodium excretion ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of systemic arterial blood pressure by atrial natriuretic peptide IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of systemic arterial blood pressure by atrial natriuretic peptide ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
actin cytoskeleton IDA
Inferred from Direct Assay
more info
 
cell surface IEA
Inferred from Electronic Annotation
more info
 
extracellular region IEA
Inferred from Electronic Annotation
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
nuclear body IDA
Inferred from Direct Assay
more info
 
plasma membrane IDA
Inferred from Direct Assay
more info
 
plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
atrial natriuretic peptide-converting enzyme
Names
heart-specific serine proteinase ATC2
pro-ANP-convertase
pro-ANP-converting enzyme
transmembrane protease serine 10

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_032679.1 RefSeqGene

    Range
    4976..249042
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001278585.1NP_001265514.1  atrial natriuretic peptide-converting enzyme isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks two in-frame exons in the coding region, compared to variant 1. The resulting isoform (2) lacks two internal segments, compared to isoform 1.
    Source sequence(s)
    AF133845, AI378383, AK304038, AK304466
    Consensus CDS
    CCDS75122.1
    UniProtKB/Swiss-Prot
    Q9Y5Q5
    UniProtKB/TrEMBL
    A0A087X1D5, B4E1Y7, B4E2W9
    Related
    ENSP00000484087.1, ENST00000610355.4
    Conserved Domains (6) summary
    cd07445
    Location:69196
    CRD_corin_1; One of two cysteine-rich domains of the corin protein, a type II transmembrane serine protease
    cd07888
    Location:350471
    CRD_corin_2; One of two cysteine-rich domains of the corin protein, a type II transmembrane serine protease
    smart00020
    Location:697926
    Tryp_SPc; Trypsin-like serine protease
    smart00202
    Location:586682
    SR; Scavenger receptor Cys-rich
    cd00112
    Location:476510
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
    cd00190
    Location:698929
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
  2. NM_001278586.2NP_001265515.1  atrial natriuretic peptide-converting enzyme isoform 3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks an in-frame internal exon and multiple 3' terminal exons, and its transcription extends past a splice site that is used in variant 1, resulting in a novel 3' coding region and 3' UTR compared to variant 1. The resulting isoform (3) is shorter; it lacks an internal segment and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AI338960, AK304466
    Consensus CDS
    CCDS63958.1
    UniProtKB/TrEMBL
    B4E2W9, J3KR83
    Related
    ENSP00000423216.1, ENST00000504584.1
    Conserved Domains (3) summary
    cd07445
    Location:135263
    CRD_corin_1; One of two cysteine-rich domains of the corin protein, a type II transmembrane serine protease
    cd07888
    Location:417538
    CRD_corin_2; One of two cysteine-rich domains of the corin protein, a type II transmembrane serine protease
    cd00112
    Location:543577
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
  3. NM_006587.4NP_006578.2  atrial natriuretic peptide-converting enzyme isoform 1

    See identical proteins and their annotated locations for NP_006578.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AC092597, AF133845, AI378383, AK304466
    Consensus CDS
    CCDS3477.1
    UniProtKB/Swiss-Prot
    Q9Y5Q5
    UniProtKB/TrEMBL
    B4E2W9
    Related
    ENSP00000273857.4, ENST00000273857.9
    Conserved Domains (7) summary
    cd07445
    Location:135263
    CRD_corin_1; One of two cysteine-rich domains of the corin protein, a type II transmembrane serine protease
    cd07888
    Location:454575
    CRD_corin_2; One of two cysteine-rich domains of the corin protein, a type II transmembrane serine protease
    smart00020
    Location:8011030
    Tryp_SPc; Trypsin-like serine protease
    smart00202
    Location:690786
    SR; Scavenger receptor Cys-rich
    cd00112
    Location:580614
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
    cd00190
    Location:8021033
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
    pfam00057
    Location:347377
    Ldl_recept_a; Low-density lipoprotein receptor domain class A

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109.20190905

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p13 Primary Assembly

    Range
    47593998..47838106 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Support Center