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PPP4R2 protein phosphatase 4 regulatory subunit 2 [ Homo sapiens (human) ]

Gene ID: 151987, updated on 13-Mar-2020

Summary

Official Symbol
PPP4R2provided by HGNC
Official Full Name
protein phosphatase 4 regulatory subunit 2provided by HGNC
Primary source
HGNC:HGNC:18296
See related
Ensembl:ENSG00000163605 MIM:613822
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PP4R2
Summary
The protein encoded by this gene is a regulatory subunit of the serine/threonine-protein phosphatase 4 complex. In addition to being required for efficient DNA double strand break repair, this complex plays a role in organization of microtubules at centrosomes and processing of spliceosomal snRNPs. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2015]
Expression
Ubiquitous expression in bone marrow (RPKM 21.8), testis (RPKM 13.7) and 25 other tissues See more
Orthologs

Genomic context

See PPP4R2 in Genome Data Viewer
Location:
3p13
Exon count:
12
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 3 NC_000003.12 (72996743..73069201)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (73045985..73118349)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene glucoside xylosyltransferase 2 Neighboring gene lysosomal protein transmembrane 4 beta pseudogene 2 Neighboring gene ferritin heavy chain 1 pseudogene 23 Neighboring gene Sharpr-MPRA regulatory region 10785 Neighboring gene RNA, U7 small nuclear 19 pseudogene Neighboring gene uncharacterized LOC107986098 Neighboring gene endogenous Bornavirus like nucleoprotein 2 Neighboring gene RNA, U6 small nuclear 557, pseudogene Neighboring gene RNA, U2 small nuclear 64, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC131930

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding, bridging IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein phosphatase regulator activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein phosphatase regulator activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
Process Evidence Code Pubs
RNA splicing IEA
Inferred from Electronic Annotation
more info
 
cellular protein modification process TAS
Traceable Author Statement
more info
PubMed 
mRNA processing IEA
Inferred from Electronic Annotation
more info
 
protein dephosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of double-strand break repair via homologous recombination IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of phosphoprotein phosphatase activity IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
centrosome TAS
Traceable Author Statement
more info
PubMed 
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
protein phosphatase 4 complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein phosphatase 4 complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
serine/threonine-protein phosphatase 4 regulatory subunit 2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001318025.2NP_001304954.1  serine/threonine-protein phosphatase 4 regulatory subunit 2 isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    AC098481, AC103559
    UniProtKB/Swiss-Prot
    Q9NY27
    Conserved Domains (2) summary
    pfam09184
    Location:9202
    PPP4R2; PPP4R2
    cl26761
    Location:141360
    MDN1; Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis]
  2. NM_001318026.1NP_001304955.1  serine/threonine-protein phosphatase 4 regulatory subunit 2 isoform 3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) uses an alternate first exon compared to variant 1. The resulting isoform (3) is shorter at the N-terminus compared to isoform 1.
    Source sequence(s)
    AC103559, AF327345, HY034679, R44190
    UniProtKB/Swiss-Prot
    Q9NY27
    Conserved Domains (1) summary
    pfam09184
    Location:1220
    PPP4R2; PPP4R2
  3. NM_001318027.2NP_001304956.1  serine/threonine-protein phosphatase 4 regulatory subunit 2 isoform 4

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) lacks an alternate exon and uses an alternate splice junction compared to variant 1. The resulting isoform (4) has a shorter and distinct N-terminus compared to isoform 1.
    Source sequence(s)
    AC098481, AC103559
    UniProtKB/Swiss-Prot
    Q9NY27
    Conserved Domains (1) summary
    COG5271
    Location:27246
    MDN1; Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis]
  4. NM_001318028.2NP_001304957.1  serine/threonine-protein phosphatase 4 regulatory subunit 2 isoform 5

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) contains two alternate exons in place of the last seven exons compared to variant 1. The resulting isoform (5) has a shorter and distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AC098481, BX089727, DB469745
    Consensus CDS
    CCDS82805.1
    UniProtKB/TrEMBL
    C9IZF4
    Related
    ENSP00000418675.1, ENST00000495566.1
    Conserved Domains (1) summary
    pfam09184
    Location:957
    PPP4R2; PPP4R2
  5. NM_174907.4NP_777567.1  serine/threonine-protein phosphatase 4 regulatory subunit 2 isoform 1

    See identical proteins and their annotated locations for NP_777567.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AC098481, AC103559
    Consensus CDS
    CCDS2917.1
    UniProtKB/Swiss-Prot
    Q9NY27
    Related
    ENSP00000349124.5, ENST00000356692.10
    Conserved Domains (2) summary
    pfam09184
    Location:9259
    PPP4R2; PPP4R2
    cl26761
    Location:198417
    MDN1; Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis]

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p13 Primary Assembly

    Range
    72996743..73069201
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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