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Hba-a1 hemoglobin alpha, adult chain 1 [ Mus musculus (house mouse) ]

Gene ID: 15122, updated on 18-Apr-2024

Summary

Official Symbol
Hba-a1provided by MGI
Official Full Name
hemoglobin alpha, adult chain 1provided by MGI
Primary source
MGI:MGI:96015
See related
Ensembl:ENSMUSG00000069919 AllianceGenome:MGI:96015
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Hba; Hba1; Hbat1
Summary
Predicted to enable several functions, including heme binding activity; oxygen binding activity; and oxygen carrier activity. Predicted to contribute to haptoglobin binding activity and peroxidase activity. Acts upstream of or within several processes, including erythrocyte development; in utero embryonic development; and response to stilbenoid. Located in myelin sheath. Is expressed in several structures, including blood vessel; early conceptus; hematopoietic system; liver; and visceral pericardium. Human ortholog(s) of this gene implicated in Heinz body anemia; alpha thalassemia; familial erythrocytosis 7; and hemoglobin H disease. Orthologous to human HBA2 (hemoglobin subunit alpha 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in spleen adult (RPKM 54307.5), heart adult (RPKM 17770.4) and 4 other tissues See more
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Genomic context

Location:
11 A4; 11 18.86 cM
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (32233672..32234486)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (32283672..32284486)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene alpha-globin locus regulatory region Neighboring gene N-methylpurine-DNA glycosylase Neighboring gene nitrogen permease regulator-like 3 Neighboring gene hemoglobin X, alpha-like embryonic chain in Hba complex Neighboring gene hemoglobin, theta 1B Neighboring gene hemoglobin alpha, adult chain 2

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables G protein-coupled receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables amyloid-beta binding ISO
Inferred from Sequence Orthology
more info
 
contributes_to haptoglobin binding IBA
Inferred from Biological aspect of Ancestor
more info
 
contributes_to haptoglobin binding ISO
Inferred from Sequence Orthology
more info
 
enables heme binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables heme binding ISO
Inferred from Sequence Orthology
more info
 
enables organic acid binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables organic acid binding ISO
Inferred from Sequence Orthology
more info
 
enables oxygen binding IBA
Inferred from Biological aspect of Ancestor
more info
 
contributes_to oxygen binding ISO
Inferred from Sequence Orthology
more info
 
enables oxygen carrier activity IBA
Inferred from Biological aspect of Ancestor
more info
 
contributes_to peroxidase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
contributes_to peroxidase activity ISO
Inferred from Sequence Orthology
more info
 
enables protein-containing complex binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in carbon dioxide transport NAS
Non-traceable Author Statement
more info
PubMed 
acts_upstream_of_or_within erythrocyte development IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in hydrogen peroxide catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within in utero embryonic development IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within response to bacterium IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to stilbenoid IEP
Inferred from Expression Pattern
more info
PubMed 
Component Evidence Code Pubs
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
 
part_of haptoglobin-hemoglobin complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of haptoglobin-hemoglobin complex ISO
Inferred from Sequence Orthology
more info
 
part_of hemoglobin complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of hemoglobin complex IPI
Inferred from Physical Interaction
more info
PubMed 
part_of hemoglobin complex ISO
Inferred from Sequence Orthology
more info
 
located_in myelin sheath HDA PubMed 

General protein information

Preferred Names
hemoglobin subunit alpha
Names
alpha 1 globin
alpha globin 1
alpha-globin
haemaglobin alpha 1
hemoglobin alpha chain

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_008218.2NP_032244.2  hemoglobin subunit alpha

    See identical proteins and their annotated locations for NP_032244.2

    Status: VALIDATED

    Source sequence(s)
    AK011055, BC043020
    Consensus CDS
    CCDS24523.1
    UniProtKB/Swiss-Prot
    P01942
    UniProtKB/TrEMBL
    A8DUV3, Q8BPF4, Q91VB8, Q9CWS5, Q9CY06
    Related
    ENSMUSP00000090897.4, ENSMUST00000093209.4
    Conserved Domains (1) summary
    cd08927
    Location:3142
    Hb-alpha_like; Hemoglobin alpha, zeta, mu, theta, and related Hb subunits

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    32233672..32234486
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)