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METTL21A methyltransferase like 21A [ Homo sapiens (human) ]

Gene ID: 151194, updated on 7-Jun-2020

Summary

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Official Symbol
METTL21Aprovided by HGNC
Official Full Name
methyltransferase like 21Aprovided by HGNC
Primary source
HGNC:HGNC:30476
See related
Ensembl:ENSG00000144401 MIM:615257
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
FAM119A; HCA557b; HSPA-KMT
Expression
Ubiquitous expression in lymph node (RPKM 1.8), spleen (RPKM 1.7) and 25 other tissues See more
Orthologs
mouse all

Genomic context

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See METTL21A in Genome Data Viewer
Location:
2q33.3
Exon count:
9
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 2 NC_000002.12 (207580631..207626053, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (208473839..208490652, complement)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 1802 Neighboring gene microRNA 1302-4 Neighboring gene uncharacterized LOC105373851 Neighboring gene cAMP responsive element binding protein 1 Neighboring gene long intergenic non-protein coding RNA 1857 Neighboring gene ribosomal protein S29 pseudogene 9

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Genome-wide association study identifies a potent locus associated with human opioid sensitivity. Nishizawa D, et al. Mol Psychiatry, 2014 Jan. PMID 23183491, Free PMC Article
  2. Saccharomyces cerevisiae Eukaryotic Elongation Factor 1A (eEF1A) Is Methylated at Lys-390 by a METTL21-Like Methyltransferase. Jakobsson ME, et al. PLoS One, 2015. PMID 26115316, Free PMC Article
  3. Lysine methylation of VCP by a member of a novel human protein methyltransferase family. Kernstock S, et al. Nat Commun, 2012. PMID 22948820
  4. Identification and characterization of a novel human methyltransferase modulating Hsp70 protein function through lysine methylation. Jakobsson ME, et al. J Biol Chem, 2013 Sep 27. PMID 23921388, Free PMC Article
  5. Genome-wide association study combining pathway analysis for typical sporadic amyotrophic lateral sclerosis in Chinese Han populations. Xie T, et al. Neurobiol Aging, 2014 Jul. PMID 24529757

See all (19) citations in PubMed

See citations in PubMed for homologs of this gene provided by HomoloGene

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. methyltransferase METTL21A is the enzyme responsible for trimethylation of a conserved lysine residue found in several human Hsp70 (HSPA) proteins
    Title: Identification and characterization of a novel human methyltransferase modulating Hsp70 protein function through lysine methylation.
  2. METTL21A trimethylates Lys-561 in Hsp70 and corresponding residues in other isoforms (Hsc70, BiP)
    Title: A newly uncovered group of distantly related lysine methyltransferases preferentially interact with molecular chaperones to regulate their activity.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

NHGRI GWAS Catalog

Description
Genome-wide association study combining pathway analysis for typical sporadic amyotrophic lateral sclerosis in Chinese Han populations.
NHGRI GWA Catalog
Genome-wide association study identifies a potent locus associated with human opioid sensitivity.
NHGRI GWA Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC45373

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATPase binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Hsp70 protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
heat shock protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
protein methyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
protein-lysine N-methyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
protein-lysine N-methyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
protein-lysine N-methyltransferase activity TAS
Traceable Author Statement
more info
  
Process Evidence Code Pubs
peptidyl-lysine methylation IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
peptidyl-lysine methylation IDA
Inferred from Direct Assay
more info
 PubMed 
protein methylation IDA
Inferred from Direct Assay
more info
 PubMed 
protein methylation TAS
Traceable Author Statement
more info
  
NOT regulation of ATPase activity IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
cytosol IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
nucleoplasm TAS
Traceable Author Statement
more info
  
protein-containing complex IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
protein N-lysine methyltransferase METTL21A
Names
HSPA lysine methyltransferase
family with sequence similarity 119, member A
heat shock protein 70kDa lysine (K) methyltransferase
hepatocellular carcinoma-associated antigen 557b
methyltransferase-like protein 21A
NP_001120867.1
NP_001294950.1
NP_001317059.1
NP_001317060.1
NP_001317061.1
NP_001317062.1
NP_001317063.1
NP_001317064.1
NP_001317065.1
NP_001317066.1
NP_660323.3
XP_005246393.1
XP_005246394.1
XP_005246396.1
XP_005246397.1
XP_006712390.1
XP_011509026.1
XP_011509027.1
XP_011509029.1
XP_011509030.1
XP_011509031.1
XP_016858933.1
XP_016858934.1
XP_016858935.1
XP_016858936.1
XP_024308489.1
XP_024308490.1
XP_024308491.1
XP_024308492.1
XP_024308493.1
XP_024308494.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001127395.3 → NP_001120867.1  protein N-lysine methyltransferase METTL21A isoform 1

    See identical proteins and their annotated locations for NP_001120867.1

    Status: VALIDATED

    Source sequence(s)
    AC079767, BC033720, BG832122
    Consensus CDS
    CCDS2376.1
    UniProtKB/Swiss-Prot
    Q8WXB1
    Related
    ENSP00000415115.1, ENST00000411432.5
    Conserved Domains (1) summary
    pfam10294
    Location:25 → 190
    Methyltransf_16; Lysine methyltransferase

  2. NM_001308021.3 → NP_001294950.1  protein N-lysine methyltransferase METTL21A isoform 2

    See identical proteins and their annotated locations for NP_001294950.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks the 3' terminal exon used in variant 1 and contains two alternate 3' exons. This results in a novel 3' coding region and 3' UTR, compared to variant 1. It encodes isoform 2 which is shorter and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AC079767, BC009462, BG198655, CN367990
    Consensus CDS
    CCDS77514.1
    UniProtKB/Swiss-Prot
    Q8WXB1
    UniProtKB/TrEMBL
    C9JES0
    Related
    ENSP00000416570.1, ENST00000432416.5
    Conserved Domains (1) summary
    cl17173
    Location:25 → 87
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

  3. NM_001330130.2 → NP_001317059.1  protein N-lysine methyltransferase METTL21A isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC079767, AF455817
    Consensus CDS
    CCDS2376.1
    UniProtKB/Swiss-Prot
    Q8WXB1
    Related
    ENSP00000385481.2, ENST00000406927.6
    Conserved Domains (1) summary
    pfam10294
    Location:25 → 190
    Methyltransf_16; Lysine methyltransferase

  4. NM_001330131.2 → NP_001317060.1  protein N-lysine methyltransferase METTL21A isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC009298, AC079767, BC009462
    Consensus CDS
    CCDS82562.1
    UniProtKB/Swiss-Prot
    Q8WXB1
    Related
    ENSP00000389684.1, ENST00000458426.5
    Conserved Domains (1) summary
    cl17173
    Location:25 → 90
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

  5. NM_001330132.1 → NP_001317061.1  protein N-lysine methyltransferase METTL21A isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC009298, AC079767
    Consensus CDS
    CCDS77514.1
    UniProtKB/TrEMBL
    C9JES0
    Conserved Domains (1) summary
    cl17173
    Location:25 → 87
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

  6. NM_001330133.1 → NP_001317062.1  protein N-lysine methyltransferase METTL21A isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC009298, AC079767
    Consensus CDS
    CCDS82562.1
    UniProtKB/Swiss-Prot
    Q8WXB1
    Conserved Domains (1) summary
    cl17173
    Location:25 → 90
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

  7. NM_001330134.1 → NP_001317063.1  protein N-lysine methyltransferase METTL21A isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC079767
    Consensus CDS
    CCDS2376.1
    UniProtKB/Swiss-Prot
    Q8WXB1
    Related
    ENSP00000392062.1, ENST00000442521.1
    Conserved Domains (1) summary
    pfam10294
    Location:25 → 190
    Methyltransf_16; Lysine methyltransferase

  8. NM_001330135.2 → NP_001317064.1  protein N-lysine methyltransferase METTL21A isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC009298, AC079767
    Consensus CDS
    CCDS82562.1
    UniProtKB/Swiss-Prot
    Q8WXB1
    Related
    ENSP00000400730.1, ENST00000425132.5
    Conserved Domains (1) summary
    cl17173
    Location:25 → 90
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

  9. NM_001330136.1 → NP_001317065.1  protein N-lysine methyltransferase METTL21A isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC009298, AC079767
    Consensus CDS
    CCDS77514.1
    UniProtKB/TrEMBL
    C9JES0
    Conserved Domains (1) summary
    cl17173
    Location:25 → 87
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

  10. NM_001330137.1 → NP_001317066.1  protein N-lysine methyltransferase METTL21A isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC079767
    Consensus CDS
    CCDS82563.1
    UniProtKB/TrEMBL
    H7BXH9
    Related
    ENSP00000272839.3, ENST00000272839.7
    Conserved Domains (1) summary
    pfam10294
    Location:25 → 208
    Methyltransf_16; Lysine methyltransferase

  11. NM_145280.6 → NP_660323.3  protein N-lysine methyltransferase METTL21A isoform 1

    See identical proteins and their annotated locations for NP_660323.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes isoform 1.
    Source sequence(s)
    AC079767, AK093812, BC033720
    Consensus CDS
    CCDS2376.1
    UniProtKB/Swiss-Prot
    Q8WXB1
    Related
    ENSP00000407622.2, ENST00000448007.6
    Conserved Domains (1) summary
    pfam10294
    Location:25 → 190
    Methyltransf_16; Lysine methyltransferase

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p13 Primary Assembly

    Range
    207580631..207626053 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024452725.1 → XP_024308493.1  protein N-lysine methyltransferase METTL21A isoform X7

    Conserved Domains (1) summary
    cl17173
    Location:25 → 87
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

  2. XM_011510728.3 → XP_011509030.1  protein N-lysine methyltransferase METTL21A isoform X5

    See identical proteins and their annotated locations for XP_011509030.1

    Conserved Domains (1) summary
    cl17173
    Location:50 → 112
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

  3. XM_024452724.1 → XP_024308492.1  protein N-lysine methyltransferase METTL21A isoform X7

    Conserved Domains (1) summary
    cl17173
    Location:25 → 87
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

  4. XM_011510727.3 → XP_011509029.1  protein N-lysine methyltransferase METTL21A isoform X5

    See identical proteins and their annotated locations for XP_011509029.1

    Conserved Domains (1) summary
    cl17173
    Location:50 → 112
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

  5. XM_017003445.1 → XP_016858934.1  protein N-lysine methyltransferase METTL21A isoform X9

  6. XM_024452726.1 → XP_024308494.1  protein N-lysine methyltransferase METTL21A isoform X10

    Conserved Domains (1) summary
    cl17173
    Location:25 → 86
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

  7. XM_011510729.2 → XP_011509031.1  protein N-lysine methyltransferase METTL21A isoform X6

    Conserved Domains (1) summary
    cl17173
    Location:50 → 111
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

  8. XM_006712327.3 → XP_006712390.1  protein N-lysine methyltransferase METTL21A isoform X3

    See identical proteins and their annotated locations for XP_006712390.1

    UniProtKB/TrEMBL
    H7BXH9
    Conserved Domains (1) summary
    pfam10294
    Location:25 → 208
    Methyltransf_16; Lysine methyltransferase

  9. XM_017003447.1 → XP_016858936.1  protein N-lysine methyltransferase METTL21A isoform X11

    Conserved Domains (1) summary
    cl17173
    Location:25 → 86
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

  10. XM_005246337.4 → XP_005246394.1  protein N-lysine methyltransferase METTL21A isoform X3

    See identical proteins and their annotated locations for XP_005246394.1

    UniProtKB/TrEMBL
    H7BXH9
    Conserved Domains (1) summary
    pfam10294
    Location:25 → 208
    Methyltransf_16; Lysine methyltransferase

  11. XM_017003446.1 → XP_016858935.1  protein N-lysine methyltransferase METTL21A isoform X11

    Conserved Domains (1) summary
    cl17173
    Location:25 → 86
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

  12. XM_005246336.3 → XP_005246393.1  protein N-lysine methyltransferase METTL21A isoform X3

    See identical proteins and their annotated locations for XP_005246393.1

    UniProtKB/TrEMBL
    H7BXH9
    Conserved Domains (1) summary
    pfam10294
    Location:25 → 208
    Methyltransf_16; Lysine methyltransferase

  13. XM_017003444.1 → XP_016858933.1  protein N-lysine methyltransferase METTL21A isoform X8

    Conserved Domains (1) summary
    cl17173
    Location:50 → 111
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

  14. XM_011510724.2 → XP_011509026.1  protein N-lysine methyltransferase METTL21A isoform X1

    Conserved Domains (1) summary
    pfam10294
    Location:50 → 233
    Methyltransf_16; Lysine methyltransferase

  15. XM_011510725.2 → XP_011509027.1  protein N-lysine methyltransferase METTL21A isoform X2

    Conserved Domains (1) summary
    pfam10294
    Location:50 → 215
    Methyltransf_16; Lysine methyltransferase

  16. XM_024452721.1 → XP_024308489.1  protein N-lysine methyltransferase METTL21A isoform X3

    Conserved Domains (1) summary
    pfam10294
    Location:25 → 208
    Methyltransf_16; Lysine methyltransferase

  17. XM_005246340.4 → XP_005246397.1  protein N-lysine methyltransferase METTL21A isoform X4

    See identical proteins and their annotated locations for XP_005246397.1

    UniProtKB/Swiss-Prot
    Q8WXB1
    Conserved Domains (1) summary
    pfam10294
    Location:25 → 190
    Methyltransf_16; Lysine methyltransferase

  18. XM_024452723.1 → XP_024308491.1  protein N-lysine methyltransferase METTL21A isoform X4

    Conserved Domains (1) summary
    pfam10294
    Location:25 → 190
    Methyltransf_16; Lysine methyltransferase

  19. XM_024452722.1 → XP_024308490.1  protein N-lysine methyltransferase METTL21A isoform X4

    Conserved Domains (1) summary
    pfam10294
    Location:25 → 190
    Methyltransf_16; Lysine methyltransferase

  20. XM_005246339.4 → XP_005246396.1  protein N-lysine methyltransferase METTL21A isoform X4

    See identical proteins and their annotated locations for XP_005246396.1

    UniProtKB/Swiss-Prot
    Q8WXB1
    Conserved Domains (1) summary
    pfam10294
    Location:25 → 190
    Methyltransf_16; Lysine methyltransferase
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8WXB1.2 GenPept UniProtKB/Swiss-Prot:Q8WXB1

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