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ADRA2B adrenoceptor alpha 2B [ Homo sapiens (human) ]

Gene ID: 151, updated on 11-Jun-2021

Summary

Official Symbol
ADRA2Bprovided by HGNC
Official Full Name
adrenoceptor alpha 2Bprovided by HGNC
Primary source
HGNC:HGNC:282
See related
Ensembl:ENSG00000274286 MIM:104260
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
FAME2; ADRA2L1; ADRARL1; ADRA2RL1; ALPHA2BAR; alpha-2BAR
Summary
This intronless gene encodes a seven-pass transmembrane protein. This protein is a member of a subfamily of G protein-coupled receptors that regulate neurotransmitter release from sympathetic nerves and from adrenergic neurons in the central nervous system. [provided by RefSeq, Apr 2014]
Orthologs
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Genomic context

See ADRA2B in Genome Data Viewer
Location:
2q11.2
Exon count:
1
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 2 NC_000002.12 (96112876..96116571, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (96778624..96782310, complement)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene glycerol-3-phosphate acyltransferase 2, mitochondrial Neighboring gene uncharacterized LOC105373493 Neighboring gene uncharacterized LOC105373494 Neighboring gene astacin like metalloendopeptidase Neighboring gene dual specificity phosphatase 2

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables G protein-coupled receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables alpha2-adrenergic receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables alpha2-adrenergic receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
enables epinephrine binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables epinephrine binding IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in G protein-coupled receptor signaling pathway TAS
Traceable Author Statement
more info
 
involved_in activation of MAPK activity IEA
Inferred from Electronic Annotation
more info
 
involved_in activation of protein kinase B activity IDA
Inferred from Direct Assay
more info
PubMed 
involved_in adenylate cyclase-activating adrenergic receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in adrenergic receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cell-cell signaling TAS
Traceable Author Statement
more info
PubMed 
involved_in female pregnancy IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of epinephrine secretion NAS
Non-traceable Author Statement
more info
PubMed 
involved_in negative regulation of norepinephrine secretion NAS
Non-traceable Author Statement
more info
PubMed 
involved_in negative regulation of norepinephrine secretion TAS
Traceable Author Statement
more info
PubMed 
involved_in platelet activation IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of MAPK cascade IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of blood pressure IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of neuron differentiation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of uterine smooth muscle contraction IEA
Inferred from Electronic Annotation
more info
 
involved_in receptor transactivation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of vascular associated smooth muscle contraction IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in cell surface IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
 
is_active_in integral component of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in intracellular membrane-bounded organelle IDA
Inferred from Direct Assay
more info
 
located_in plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
alpha-2B adrenergic receptor
Names
ADRA2B adrenergic, alpha-2B-, receptor
G-protein coupled receptor
alpha-2 adrenergic receptor subtype C2
alpha-2-adrenergic receptor-like 1
alpha-2B adrenoreceptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_032950.1 RefSeqGene

    Range
    4579..8274
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_000682.7NP_000673.2  alpha-2B adrenergic receptor

    See identical proteins and their annotated locations for NP_000673.2

    Status: REVIEWED

    Source sequence(s)
    AC092603, BC133021
    Consensus CDS
    CCDS56129.1
    UniProtKB/Swiss-Prot
    P18089
    Related
    ENSP00000480573.1, ENST00000620793.2
    Conserved Domains (1) summary
    cd15321
    Location:7437
    7tmA_alpha2B_AR; alpha-2 adrenergic receptors subtype B, member of the class A family of seven-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p13 Primary Assembly

    Range
    96112876..96116571 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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