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GPAT2 glycerol-3-phosphate acyltransferase 2, mitochondrial [ Homo sapiens (human) ]

Gene ID: 150763, updated on 20-Mar-2020

Summary

Official Symbol
GPAT2provided by HGNC
Official Full Name
glycerol-3-phosphate acyltransferase 2, mitochondrialprovided by HGNC
Primary source
HGNC:HGNC:27168
See related
Ensembl:ENSG00000186281 MIM:616431
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CT123
Expression
Broad expression in testis (RPKM 7.1), spleen (RPKM 3.6) and 22 other tissues See more
Orthologs

Genomic context

See GPAT2 in Genome Data Viewer
Location:
2q11.2
Exon count:
23
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 2 NC_000002.12 (96021946..96035974, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (96687694..96701722, complement)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene ankyrin repeat domain 36C Neighboring gene RNA, 7SL, cytoplasmic 210, pseudogene Neighboring gene fumarylacetoacetate hydrolase domain containing 2C, pseudogene Neighboring gene uncharacterized LOC105373493 Neighboring gene uncharacterized LOC105373494 Neighboring gene adrenoceptor alpha 2B

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of glycerol-3-phosphate acyltransferase 2, mitochondrial (GPAT2) by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
glycerol-3-phosphate O-acyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
glycerol-3-phosphate O-acyltransferase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
sn-1-glycerol-3-phosphate C16:0-DCA-CoA acyl transferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
CDP-diacylglycerol biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
fatty acid metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
glycerol-3-phosphate metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
glycerol-3-phosphate metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
 
phosphatidic acid biosynthetic process TAS
Traceable Author Statement
more info
 
phospholipid biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
piRNA biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
piRNA biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
 
triglyceride biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
triglyceride biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
mitochondrial membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mitochondrial outer membrane TAS
Traceable Author Statement
more info
 
mitochondrion ISS
Inferred from Sequence or Structural Similarity
more info
 
mitochondrion NAS
Non-traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
glycerol-3-phosphate acyltransferase 2, mitochondrial
Names
cancer/testis antigen 123
NP_001308454.1
NP_001308455.1
NP_001308456.1
NP_001308457.1
NP_001308458.1
NP_001308459.1
NP_001308460.1
NP_997211.2
XP_005263945.1
XP_006712371.1
XP_006712374.1
XP_006712375.1
XP_006712376.1
XP_016858913.1
XP_016858914.1
XP_016858915.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001321525.1NP_001308454.1  glycerol-3-phosphate acyltransferase 2, mitochondrial isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC013272
    UniProtKB/Swiss-Prot
    Q6NUI2
    Conserved Domains (1) summary
    cd07993
    Location:176388
    LPLAT_DHAPAT-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like
  2. NM_001321526.1NP_001308455.1  glycerol-3-phosphate acyltransferase 2, mitochondrial isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC013272
    UniProtKB/Swiss-Prot
    Q6NUI2
    Conserved Domains (1) summary
    cd07993
    Location:176388
    LPLAT_DHAPAT-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like
  3. NM_001321527.1NP_001308456.1  glycerol-3-phosphate acyltransferase 2, mitochondrial isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC013272
    UniProtKB/Swiss-Prot
    Q6NUI2
    Conserved Domains (1) summary
    cd07993
    Location:176388
    LPLAT_DHAPAT-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like
  4. NM_001321528.1NP_001308457.1  glycerol-3-phosphate acyltransferase 2, mitochondrial isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC013272
    Conserved Domains (1) summary
    cd07993
    Location:176388
    LPLAT_DHAPAT-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like
  5. NM_001321529.1NP_001308458.1  glycerol-3-phosphate acyltransferase 2, mitochondrial isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC013272
    Conserved Domains (1) summary
    cl17185
    Location:176317
    LPLAT; Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis
  6. NM_001321530.1NP_001308459.1  glycerol-3-phosphate acyltransferase 2, mitochondrial isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC013272, AK131194, AK298131, BC068596
    Consensus CDS
    CCDS82482.1
    UniProtKB/Swiss-Prot
    Q6NUI2
    UniProtKB/TrEMBL
    B4DNZ9, E9PE95
    Related
    ENSP00000393770.1, ENST00000453542.5
    Conserved Domains (1) summary
    cl17185
    Location:176317
    LPLAT; Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis
  7. NM_001321531.1NP_001308460.1  glycerol-3-phosphate acyltransferase 2, mitochondrial isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC013272, AK131194, BC068596
    UniProtKB/Swiss-Prot
    Q6NUI2
    Conserved Domains (1) summary
    cd07993
    Location:176388
    LPLAT_DHAPAT-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like
  8. NM_207328.3NP_997211.2  glycerol-3-phosphate acyltransferase 2, mitochondrial isoform 1

    See identical proteins and their annotated locations for NP_997211.2

    Status: VALIDATED

    Source sequence(s)
    AK131194, BC042847, BC068596, CB961934
    Consensus CDS
    CCDS42714.1
    UniProtKB/Swiss-Prot
    Q6NUI2
    Related
    ENSP00000352547.4, ENST00000359548.8
    Conserved Domains (1) summary
    cd07993
    Location:176388
    LPLAT_DHAPAT-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p13 Primary Assembly

    Range
    96021946..96035974 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005263888.4XP_005263945.1  glycerol-3-phosphate acyltransferase 2, mitochondrial isoform X6

    See identical proteins and their annotated locations for XP_005263945.1

    UniProtKB/Swiss-Prot
    Q6NUI2
    Conserved Domains (1) summary
    cd07993
    Location:176388
    LPLAT_DHAPAT-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like
  2. XM_017003426.2XP_016858915.1  glycerol-3-phosphate acyltransferase 2, mitochondrial isoform X8

  3. XM_006712313.4XP_006712376.1  glycerol-3-phosphate acyltransferase 2, mitochondrial isoform X5

    Conserved Domains (1) summary
    cd07993
    Location:176388
    LPLAT_DHAPAT-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like
  4. XM_006712311.4XP_006712374.1  glycerol-3-phosphate acyltransferase 2, mitochondrial isoform X3

    Related
    ENST00000484440.5
    Conserved Domains (1) summary
    cd07993
    Location:176388
    LPLAT_DHAPAT-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like
  5. XM_017003424.1XP_016858913.1  glycerol-3-phosphate acyltransferase 2, mitochondrial isoform X1

    UniProtKB/Swiss-Prot
    Q6NUI2
    Related
    ENST00000486463.5
    Conserved Domains (1) summary
    cd07993
    Location:176388
    LPLAT_DHAPAT-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like
  6. XM_017003425.2XP_016858914.1  glycerol-3-phosphate acyltransferase 2, mitochondrial isoform X7

  7. XM_006712312.4XP_006712375.1  glycerol-3-phosphate acyltransferase 2, mitochondrial isoform X4

    Conserved Domains (1) summary
    cd07993
    Location:176388
    LPLAT_DHAPAT-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like
  8. XM_006712308.4XP_006712371.1  glycerol-3-phosphate acyltransferase 2, mitochondrial isoform X2

    Conserved Domains (1) summary
    cd07993
    Location:176388
    LPLAT_DHAPAT-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like
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