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CTRL chymotrypsin like [ Homo sapiens (human) ]

Gene ID: 1506, updated on 23-Nov-2023

Summary

Official Symbol
CTRLprovided by HGNC
Official Full Name
chymotrypsin likeprovided by HGNC
Primary source
HGNC:HGNC:2524
See related
Ensembl:ENSG00000141086 MIM:118888; AllianceGenome:HGNC:2524
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CTRL1
Summary
This gene encodes a serine-type endopeptidase with chymotrypsin- and elastase-2-like activities. The gene encoding this zymogen is expressed specifically in the pancreas and likely functions as a digestive enzyme. [provided by RefSeq, Sep 2016]
Expression
Restricted expression toward pancreas (RPKM 884.9) See more
Orthologs
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Genomic context

See CTRL in Genome Data Viewer
Location:
16q22.1
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 16 NC_000016.10 (67929574..67931862, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 16 NC_060940.1 (73725348..73727636, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (67963477..67965765, complement)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene H3K27ac hESC enhancer GRCh37_chr16:67907171-67907671 Neighboring gene enhancer of mRNA decapping 4 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10992 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:67918365-67918874 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:67918875-67919382 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7631 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7632 Neighboring gene neuritin 1 like Neighboring gene protein serine kinase H1 Neighboring gene ReSE screen-validated silencer GRCh37_chr16:67944133-67944345 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:67949619-67950142 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:67953295-67953800 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:67960875-67961376 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:67962749-67963459 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:67964222-67964739 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:67964740-67965256 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10993 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10994 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10995 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10996 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:67973687-67974296 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10998 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:67976255-67977154 Neighboring gene proteasome 20S subunit beta 10 Neighboring gene solute carrier family 12 member 4 Neighboring gene lecithin-cholesterol acyltransferase

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Potential readthrough

Included gene: PSMB10

Clone Names

  • MGC70821

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables serine-type endopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables serine-type peptidase activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
involved_in protein catabolic process IC
Inferred by Curator
more info
PubMed 
involved_in proteolysis IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
located_in extracellular space IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
chymotrypsin-like protease CTRL-1
NP_001898.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_051639.1 RefSeqGene

    Range
    5014..7302
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001907.3NP_001898.1  chymotrypsin-like protease CTRL-1 precursor

    See identical proteins and their annotated locations for NP_001898.1

    Status: REVIEWED

    Source sequence(s)
    X71877
    Consensus CDS
    CCDS10852.1
    UniProtKB/Swiss-Prot
    P40313
    UniProtKB/TrEMBL
    Q53FV9
    Related
    ENSP00000458537.2, ENST00000574481.6
    Conserved Domains (1) summary
    cd00190
    Location:34260
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p14 Primary Assembly

    Range
    67929574..67931862 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060940.1 Alternate T2T-CHM13v2.0

    Range
    73725348..73727636 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)