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SATB2-AS1 SATB2 antisense RNA 1 [ Homo sapiens (human) ]

Gene ID: 150538, updated on 17-Sep-2024

Summary

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Official Symbol
SATB2-AS1provided by HGNC
Official Full Name
SATB2 antisense RNA 1provided by HGNC
Primary source
HGNC:HGNC:26490
See related
Ensembl:ENSG00000225953 AllianceGenome:HGNC:26490
Gene type
ncRNA
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Expression
Biased expression in colon (RPKM 4.3), appendix (RPKM 0.8) and 2 other tissues See more
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Genomic context

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See SATB2-AS1 in Genome Data Viewer
Location:
2q33.1
Exon count:
2
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (199468098..199472758)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (199951867..199956527)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (200332821..200337481)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene MIA SH3 domain ER export factor 2 pseudogene Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr2:200043891-200044479 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr2:200049723-200050231 Neighboring gene RNA, U7 small nuclear 147 pseudogene Neighboring gene NANOG hESC enhancer GRCh37_chr2:200116810-200117393 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr2:200136608-200137807 Neighboring gene SATB homeobox 2 Neighboring gene NANOG hESC enhancer GRCh37_chr2:200288662-200289237 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12219 Neighboring gene Sharpr-MPRA regulatory region 6083 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:200327038-200327803 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12220 Neighboring gene long intergenic non-protein coding RNA 1877 Neighboring gene selenophosphate synthetase 1 pseudogene 6

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. The lncRNAs RP1-261G23.7, RP11-69E11.4 and SATB2-AS1 are a novel clinical signature for predicting recurrent osteosarcoma. Ying T, et al. Biosci Rep, 2020 Jan 31. PMID 31850493, Free PMC Article
  2. LncRNA SATB2-AS1 inhibits tumor metastasis and affects the tumor immune cell microenvironment in colorectal cancer by regulating SATB2. Xu M, et al. Mol Cancer, 2019 Sep 6. PMID 31492160, Free PMC Article
  3. A novel antisense long non-coding RNA SATB2-AS1 overexpresses in osteosarcoma and increases cell proliferation and growth. Liu SH, et al. Mol Cell Biochem, 2017 Jun. PMID 28190168
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. Ota T, et al. Nat Genet, 2004 Jan. PMID 14702039
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The lncRNAs RP1-261G23.7, RP11-69E11.4 and SATB2-AS1 are a novel clinical signature for predicting recurrent osteosarcoma.
    Title: The lncRNAs RP1-261G23.7, RP11-69E11.4 and SATB2-AS1 are a novel clinical signature for predicting recurrent osteosarcoma.
  2. This study reveals the functions of SATB2-AS1 in CRC tumorigenesis and progression, suggesting new biomarkers and therapeutic targets in CRC.
    Title: LncRNA SATB2-AS1 inhibits tumor metastasis and affects the tumor immune cell microenvironment in colorectal cancer by regulating SATB2.
  3. data demonstrate that an antisense non-coding RNA regulates the expression of its sense gene, and increases the cell growth, therefore pointing the pivotal functions of SATB2-AS1 in osteosarcoma.
    Title: A novel antisense long non-coding RNA SATB2-AS1 overexpresses in osteosarcoma and increases cell proliferation and growth.
Submit: New GeneRIF Correction

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

General gene information

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Markers

Other Names

  • SATB2 antisense RNA 1 (non-protein coding)

Clone Names

  • FLJ32063, MGC126831

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

RNA

  1. NR_026830.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AK123639, BC035902
    Related
    ENST00000450728.1

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

    Range
    199468098..199472758
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060926.1 Alternate T2T-CHM13v2.0

    Range
    199951867..199956527
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_153031.1: Suppressed sequence

    Description
    NM_153031.1: This RefSeq was permanently suppressed because currently there is support for the transcript but not for the protein.
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

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