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YDJC YdjC chitooligosaccharide deacetylase homolog [ Homo sapiens (human) ]

Gene ID: 150223, updated on 29-Oct-2022

Summary

Official Symbol
YDJCprovided by HGNC
Official Full Name
YdjC chitooligosaccharide deacetylase homologprovided by HGNC
Primary source
HGNC:HGNC:27158
See related
Ensembl:ENSG00000161179 MIM:619770; AllianceGenome:HGNC:27158
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Predicted to enable deacetylase activity and magnesium ion binding activity. Predicted to be involved in carbohydrate metabolic process. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in kidney (RPKM 4.9), colon (RPKM 4.2) and 25 other tissues See more
Orthologs
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Genomic context

See YDJC in Genome Data Viewer
Location:
22q11.21
Exon count:
5
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 22 NC_000022.11 (21628089..21630022, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 22 NC_060946.1 (22041573..22043506, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 22 NC_000022.10 (21982378..21984311, complement)

Chromosome 22 - NC_000022.11Genomic Context describing neighboring genes Neighboring gene RIMS binding protein 3C Neighboring gene ubiquitin conjugating enzyme E2 L3 Neighboring gene VISTA enhancer hs2026 Neighboring gene coiled-coil domain containing 116 Neighboring gene stromal cell derived factor 2 like 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Phenotypes

EBI GWAS Catalog

Description
Genetics of rheumatoid arthritis contributes to biology and drug discovery.
EBI GWAS Catalog
Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci.
EBI GWAS Catalog
Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
EBI GWAS Catalog
Meta-analysis of genome-wide association studies in celiac disease and rheumatoid arthritis identifies fourteen non-HLA shared loci.
EBI GWAS Catalog
Multiple common variants for celiac disease influencing immune gene expression.
EBI GWAS Catalog
Seventy-five genetic loci influencing the human red blood cell.
EBI GWAS Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC133160

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables deacetylase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables magnesium ion binding ISS
Inferred from Sequence or Structural Similarity
more info
 
Process Evidence Code Pubs
involved_in carbohydrate metabolic process IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
carbohydrate deacetylase
Names
UPF0249 protein ydjC homolog
YdjC homolog
NP_001017964.1
NP_001358279.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001017964.2NP_001017964.1  carbohydrate deacetylase isoform 1

    See identical proteins and their annotated locations for NP_001017964.1

    Status: VALIDATED

    Source sequence(s)
    BC057814, BI597711, BQ050386
    Consensus CDS
    CCDS33613.1
    UniProtKB/Swiss-Prot
    A8MPS7, Q4V9R7
    Related
    ENSP00000292778.6, ENST00000292778.11
    Conserved Domains (1) summary
    cd10806
    Location:7286
    YdjC_like_2; uncharacterized YdjC-like family proteins from eukaryotes
  2. NM_001371350.1NP_001358279.1  carbohydrate deacetylase isoform 2

    Status: VALIDATED

    Source sequence(s)
    BC096754, BC110075, BC110799
    Consensus CDS
    CCDS93126.1
    Related
    ENSP00000381847.3, ENST00000398873.4
    Conserved Domains (1) summary
    cl15692
    Location:7142
    CE4_SF; Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily

RNA

  1. NR_163922.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    BC110799, BC133043
    Related
    ENST00000415762.6
  2. NR_163923.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    BC057814, BC096754, BC110799, BM048037
  3. NR_163924.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    BC057814, BC096754, BC110799, BG105883
    Related
    ENST00000473985.1
  4. NR_163925.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    BC096754, BC110075, BC110799, BI199854

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000022.11 Reference GRCh38.p14 Primary Assembly

    Range
    21628089..21630022 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060946.1 Alternate T2T-CHM13v2.0

    Range
    22041573..22043506 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001017965.1: Suppressed sequence

    Description
    NM_001017965.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.