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ADRA2A adrenoceptor alpha 2A [ Homo sapiens (human) ]

Gene ID: 150, updated on 17-Nov-2020

Summary

Official Symbol
ADRA2Aprovided by HGNC
Official Full Name
adrenoceptor alpha 2Aprovided by HGNC
Primary source
HGNC:HGNC:281
See related
Ensembl:ENSG00000150594 MIM:104210
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ADRA2; ADRAR; ZNF32; ADRA2R; ALPHA2AAR
Summary
Alpha-2-adrenergic receptors are members of the G protein-coupled receptor superfamily. The alpha-2-adrenergic receptors are a type of adrenergic receptors (for adrenaline or epinephrine), which inhibit adenylate cyclase. These receptors include 3 highly homologous subtypes: alpha2A, alpha2B, and alpha2C. They are involved in regulating the release of neurotransmitter molecules from sympathetic nerves and from adrenergic neurons in the central nervous system. The sympathetic nervous system regulates cardiovascular function by activating adrenergic receptors in the heart, blood vessels and kidney. Studies in mouse revealed that both the alpha2A and alpha2C receptor subtypes were required for presynaptic transmitter release from the sympathetic nervous system in the heart and from central noradrenergic neurons. The alpha-2-adrenergic receptors are also involved in catecholamine signaling by extracellular regulated protein kinase 1 and 2 (ERK1/2) pathways. A clear association between the alpha-2-adrenergic receptor and disease has not been yet established. [provided by RefSeq, Sep 2019]
Orthologs

Genomic context

See ADRA2A in Genome Data Viewer
Location:
10q25.2
Exon count:
1
Annotation release Status Assembly Chr Location
109.20200815 current GRCh38.p13 (GCF_000001405.39) 10 NC_000010.11 (111077029..111080907)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (112836790..112840665)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene SHOC2 leucine rich repeat scaffold protein Neighboring gene ribosomal protein L13a pseudogene 6 Neighboring gene microRNA 548e Neighboring gene chromosome 19 open reading frame 53 pseudogene Neighboring gene HEart disease Associated Transcript 2

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
A genome-wide approach accounting for body mass index identifies genetic variants influencing fasting glycemic traits and insulin resistance.
GeneReviews: Not available
Genome-wide meta-analyses identifies seven loci associated with platelet aggregation in response to agonists.
GeneReviews: Not available
New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk.
GeneReviews: Not available

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
G protein-coupled receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
alpha-1B adrenergic receptor binding ISS
Inferred from Sequence or Structural Similarity
more info
 
alpha-2C adrenergic receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
alpha2-adrenergic receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
alpha2-adrenergic receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
alpha2-adrenergic receptor activity ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
epinephrine binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
epinephrine binding IDA
Inferred from Direct Assay
more info
PubMed 
heterotrimeric G-protein binding IDA
Inferred from Direct Assay
more info
PubMed 
identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
norepinephrine binding IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein heterodimerization activity IPI
Inferred from Physical Interaction
more info
PubMed 
protein heterodimerization activity ISS
Inferred from Sequence or Structural Similarity
more info
 
protein homodimerization activity IDA
Inferred from Direct Assay
more info
PubMed 
protein kinase binding IPI
Inferred from Physical Interaction
more info
PubMed 
thioesterase binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
G protein-coupled receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
G protein-coupled receptor signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
G protein-coupled receptor signaling pathway TAS
Traceable Author Statement
more info
 
Ras protein signal transduction TAS
Traceable Author Statement
more info
PubMed 
Rho protein signal transduction TAS
Traceable Author Statement
more info
PubMed 
actin cytoskeleton organization TAS
Traceable Author Statement
more info
PubMed 
activation of protein kinase B activity IDA
Inferred from Direct Assay
more info
PubMed 
activation of protein kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
adenylate cyclase-activating G protein-coupled receptor signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
adenylate cyclase-activating adrenergic receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
adenylate cyclase-activating adrenergic receptor signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
adenylate cyclase-inhibiting adrenergic receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
adrenergic receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
cellular response to hormone stimulus IGI
Inferred from Genetic Interaction
more info
PubMed 
fear response IEA
Inferred from Electronic Annotation
more info
 
glucose homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
intestinal absorption TAS
Traceable Author Statement
more info
PubMed 
negative regulation of calcium ion transmembrane transporter activity ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
negative regulation of calcium ion transport ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of calcium ion-dependent exocytosis IC
Inferred by Curator
more info
PubMed 
negative regulation of epinephrine secretion NAS
Non-traceable Author Statement
more info
PubMed 
negative regulation of insulin secretion IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of insulin secretion involved in cellular response to glucose stimulus IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of lipid catabolic process IGI
Inferred from Genetic Interaction
more info
PubMed 
negative regulation of norepinephrine secretion NAS
Non-traceable Author Statement
more info
PubMed 
negative regulation of norepinephrine secretion TAS
Traceable Author Statement
more info
PubMed 
phospholipase C-activating adrenergic receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
platelet activation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of MAP kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of MAPK cascade IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of cell population proliferation TAS
Traceable Author Statement
more info
PubMed 
positive regulation of cytokine production IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of epidermal growth factor-activated receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of membrane protein ectodomain proteolysis IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of potassium ion transport ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
positive regulation of wound healing IMP
Inferred from Mutant Phenotype
more info
PubMed 
receptor transactivation IDA
Inferred from Direct Assay
more info
PubMed 
regulation of insulin secretion TAS
Traceable Author Statement
more info
 
regulation of smooth muscle contraction IEA
Inferred from Electronic Annotation
more info
 
regulation of synaptic vesicle exocytosis IEA
Inferred from Electronic Annotation
more info
 
regulation of vasoconstriction IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
basolateral plasma membrane TAS
Traceable Author Statement
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
dopaminergic synapse IEA
Inferred from Electronic Annotation
more info
 
integral component of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
integral component of plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 
receptor complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
alpha-2A adrenergic receptor
Names
adrenergic, alpha-2A-, receptor
alpha-2 adrenergic receptor subtype C10
alpha-2-adrenergic receptor, platelet type
alpha-2A adrenoceptor
alpha-2A adrenoreceptor
alpha-2AAR subtype C10

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_012020.1 RefSeqGene

    Range
    4998..8876
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_000681.4NP_000672.3  alpha-2A adrenergic receptor

    See identical proteins and their annotated locations for NP_000672.3

    Status: REVIEWED

    Source sequence(s)
    AF284095, AL158163, BM682651
    Consensus CDS
    CCDS7569.2
    UniProtKB/Swiss-Prot
    P08913
    Related
    ENSP00000280155.2, ENST00000280155.4
    Conserved Domains (2) summary
    pfam00001
    Location:65441
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    cl21561
    Location:57185
    7tm_4; Olfactory receptor

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20200815

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p13 Primary Assembly

    Range
    111077029..111080907
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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