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E2 E2 protein [ Bos taurus papillomavirus 1 ]

Gene ID: 1489020, updated on 29-Oct-2023

Summary

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Gene symbol
E2
Gene description
E2 protein
Locus tag
BPVgp4
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Bos taurus papillomavirus 1
Lineage
Viruses; Monodnaviria; Shotokuvirae; Cossaviricota; Papovaviricetes; Zurhausenvirales; Papillomaviridae; Firstpapillomavirinae; Deltapapillomavirus; Deltapapillomavirus 4
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Genomic context

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Sequence:
NC_001522.1 (2608..3528)

NC_001522.1Genomic Context describing neighboring genes Neighboring gene E6 protein Neighboring gene E7 protein Neighboring gene E1 Neighboring gene E4 protein Neighboring gene E5 protein Neighboring gene L2 protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001522.1

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The structure of the extended E2 DNA-binding domain of the bovine papillomavirus-1. Leroy L, et al. Proteins, 2020 Jan. PMID 31299114
  2. Genetic analysis of the E2 transactivation domain dimerization interface from bovine papillomavirus type 1. Gagnon D, et al. Virology, 2013 May 10. PMID 23490049, Free PMC Article
  3. The truncated C-terminal E2 (E2-TR) protein of bovine papillomavirus (BPV) type-1 is a transactivator that modulates transcription in vivo and in vitro in a manner distinct from the E2-TA and E8^E2 gene products. Lace MJ, et al. Virology, 2012 Aug 1. PMID 22551766
  4. Topography of bovine papillomavirus E2 protein on the viral genome during the cell cycle. Melanson SM, et al. Virology, 2009 Oct 25. PMID 19716579, Free PMC Article
  5. Bovine papillomavirus type 1 E2 protein heterodimer is functional in papillomavirus DNA replication in vivo. Kurg R, et al. Virology, 2009 Apr 10. PMID 19232665

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The structure of the extended E2 DNA-binding domain of the bovine papillomavirus-1.
    Title: The structure of the extended E2 DNA-binding domain of the bovine papillomavirus-1.
  2. Results for this mutational analysis suggest that the transactivation domain dimerization interface may contribute to the DNA replication activity of bovine papillomavirus type 1 E2 protein
    Title: Genetic analysis of the E2 transactivation domain dimerization interface from bovine papillomavirus type 1.
  3. Authors propose a model by which bovine papillomavirus E2 transcriptional activity is controlled by bovine p300-mediated acetylation of lysine 111.
    Title: Acetylation of conserved lysines in bovine papillomavirus E2 by p300.
  4. Thus, the bovine papillomavirus-1 E2-TR modulates viral gene expression in a manner distinct from other E2 proteins.
    Title: The truncated C-terminal E2 (E2-TR) protein of bovine papillomavirus (BPV) type-1 is a transactivator that modulates transcription in vivo and in vitro in a manner distinct from the E2-TA and E8^E2 gene products.
  5. These data provide evidence that the association of bovine papillomavirus E2 with human ChlR1 contributes to a loading mechanism during DNA replication rather than direct tethering during mitotic division.
    Title: In vivo analysis of the cell cycle dependent association of the bovine papillomavirus E2 protein and ChlR1.
  6. In the present study, the authors show that TLR4 expression is significantly decreased following the exogenous expression of BPV-1 E2 and E7 in primary equine fibroblasts.
    Title: Bovine papillomavirus type 1 E2 and E7 proteins down-regulate Toll Like Receptor 4 (TLR4) expression in equine fibroblasts.
  7. BPV E2 remaines attached to definable segments of the viral genome at specific stages of the cell cycle.
    Title: Topography of bovine papillomavirus E2 protein on the viral genome during the cell cycle.
  8. In addition to Brd4's role in mediating E2 transcription and genome tethering activities, these data suggest a potential role for Brd4 in regulating E2 stability and protein levels within papillomavirus-infected cells.
    Title: Brd4 regulation of papillomavirus protein E2 stability.
  9. E2 heterodimers with single activation domain are functional in initiation of papillomavirus replication in vivo.
    Title: Bovine papillomavirus type 1 E2 protein heterodimer is functional in papillomavirus DNA replication in vivo.
  10. This study provides evidence that sumoylation has a role in the regulation of papillomavirus E2, and identifies a new mechanism for the modulation of E2 function at the post-translational level.
    Title: Modification of papillomavirus E2 proteins by the small ubiquitin-like modifier family members (SUMOs).
Submit: New GeneRIF Correction See all GeneRIFs (13)

General gene information

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Homology

General protein information

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Preferred Names
E2 protein

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001522.1 Reference assembly

    Range
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_056740.1 E2 protein [Bos taurus papillomavirus 1]

    See identical proteins and their annotated locations for NP_056740.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A1B0Z5A6
    Conserved Domains (1) summary
    pfam00508
    Location:1 → 195
    PPV_E2_N; E2 (early) protein, N terminal
Protein Accession Links
GenPept Link UniProtKB Link
CAB46512.1

Gene LinkOut

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