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Gstp1 glutathione S-transferase, pi 1 [ Mus musculus (house mouse) ]

Gene ID: 14870, updated on 8-Feb-2024

Summary

Official Symbol
Gstp1provided by MGI
Official Full Name
glutathione S-transferase, pi 1provided by MGI
Primary source
MGI:MGI:95865
See related
Ensembl:ENSMUSG00000060803 AllianceGenome:MGI:95865
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
GstpiB
Summary
Enables JUN kinase binding activity; glutathione transferase activity; and kinase regulator activity. Involved in several processes, including negative regulation of cell population proliferation; negative regulation of intracellular signal transduction; and negative regulation of macromolecule metabolic process. Acts upstream of or within glutathione metabolic process. Part of protein-containing complex. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in several diseases, including brain disease (multiple); carcinoma (multiple); hematologic cancer (multiple); reproductive organ cancer (multiple); and respiratory system disease (multiple). Orthologous to human GSTP1 (glutathione S-transferase pi 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in duodenum adult (RPKM 772.3), stomach adult (RPKM 565.6) and 27 other tissues See more
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Genomic context

See Gstp1 in Genome Data Viewer
Location:
19 A; 19 3.75 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (4085411..4087912, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (4035411..4037912, complement)

Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene double C2, gamma Neighboring gene NADH:ubiquinone oxidoreductase core subunit V1 Neighboring gene STARR-positive B cell enhancer ABC_E2517 Neighboring gene STARR-seq mESC enhancer starr_45337 Neighboring gene glutathione S-transferase, pi 2 Neighboring gene STARR-positive B cell enhancer ABC_E5673 Neighboring gene glutathione S-transferase pi 3

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1)  1 citation
  • Endonuclease-mediated (1) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables JUN kinase binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables S-nitrosoglutathione binding ISO
Inferred from Sequence Orthology
more info
 
enables dinitrosyl-iron complex binding ISO
Inferred from Sequence Orthology
more info
 
enables fatty acid binding ISO
Inferred from Sequence Orthology
more info
 
enables glutathione peroxidase activity ISO
Inferred from Sequence Orthology
more info
 
enables glutathione transferase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables glutathione transferase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables glutathione transferase activity ISO
Inferred from Sequence Orthology
more info
 
enables kinase regulator activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables organic cyclic compound binding ISO
Inferred from Sequence Orthology
more info
 
enables protein kinase binding ISO
Inferred from Sequence Orthology
more info
 
enables toxic substance binding ISO
Inferred from Sequence Orthology
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in cellular response to lipopolysaccharide IDA
Inferred from Direct Assay
more info
PubMed 
involved_in common myeloid progenitor cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in glutathione derivative biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
involved_in glutathione metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within glutathione metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in glutathione metabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in hepoxilin biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
involved_in linoleic acid metabolic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within lipid metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of ERK1 and ERK2 cascade IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of ERK1 and ERK2 cascade ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of JUN kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of JUN kinase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of JUN kinase activity ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of MAP kinase activity ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of acute inflammatory response NAS
Non-traceable Author Statement
more info
PubMed 
involved_in negative regulation of apoptotic process TAS
Traceable Author Statement
more info
PubMed 
involved_in negative regulation of biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of canonical NF-kappaB signal transduction IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of extrinsic apoptotic signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of fibroblast proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of interleukin-1 beta production IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of interleukin-1 beta production ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of leukocyte proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of monocyte chemotactic protein-1 production IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of monocyte chemotactic protein-1 production ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of neutrophil aggregation NAS
Non-traceable Author Statement
more info
PubMed 
involved_in negative regulation of nitric-oxide synthase biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of nitric-oxide synthase biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of peroxidase activity IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of protein kinase activity ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of smooth muscle cell chemotaxis ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of stress-activated MAPK cascade IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of tumor necrosis factor production IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of tumor necrosis factor production ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of vascular associated smooth muscle cell proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of superoxide anion generation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in prostaglandin metabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of ERK1 and ERK2 cascade IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of stress-activated MAPK cascade IDA
Inferred from Direct Assay
more info
PubMed 
involved_in response to reactive oxygen species IDA
Inferred from Direct Assay
more info
PubMed 
involved_in xenobiotic metabolic process ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
part_of TRAF2-GSTP1 complex ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 
part_of protein-containing complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
glutathione S-transferase P 1
Names
GST YF-YF
GST class-pi
GST-piB
Gst p-1
gst P1
preadipocyte growth factor
NP_038569.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_013541.1NP_038569.1  glutathione S-transferase P 1

    See identical proteins and their annotated locations for NP_038569.1

    Status: VALIDATED

    Source sequence(s)
    D30687
    Consensus CDS
    CCDS29411.1
    UniProtKB/Swiss-Prot
    P19157, Q8BNY4
    UniProtKB/TrEMBL
    A0A494BAW2
    Related
    ENSMUSP00000129565.2, ENSMUST00000169613.4
    Conserved Domains (3) summary
    PTZ00057
    Location:6196
    PTZ00057; glutathione s-transferase; Provisional
    cd03210
    Location:84210
    GST_C_Pi; C-terminal, alpha helical domain of Class Pi Glutathione S-transferases
    cd03076
    Location:376
    GST_N_Pi; GST_N family, Class Pi subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens, ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000085.7 Reference GRCm39 C57BL/6J

    Range
    4085411..4087912 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)