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Gstp1 glutathione S-transferase, pi 1 [ Mus musculus (house mouse) ]

Gene ID: 14870, updated on 15-Apr-2019

Summary

Official Symbol
Gstp1provided by MGI
Official Full Name
glutathione S-transferase, pi 1provided by MGI
Primary source
MGI:MGI:95865
See related
Ensembl:ENSMUSG00000060803
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
GstpiB
Expression
Ubiquitous expression in duodenum adult (RPKM 772.3), stomach adult (RPKM 565.6) and 27 other tissues See more

Genomic context

See Gstp1 in Genome Data Viewer
Location:
19 A; 19 3.75 cM
Exon count:
7
Annotation release Status Assembly Chr Location
106 current GRCm38.p4 (GCF_000001635.24) 19 NC_000085.6 (4035411..4037912, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 19 NC_000085.5 (4035411..4037912, complement)

Chromosome 19 - NC_000085.6Genomic Context describing neighboring genes Neighboring gene double C2, gamma Neighboring gene NADH:ubiquinone oxidoreductase core subunit V1 Neighboring gene glutathione S-transferase, pi 2 Neighboring gene glutathione S-transferase pi 3

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
JUN kinase binding IPI
Inferred from Physical Interaction
more info
PubMed 
S-nitrosoglutathione binding ISO
Inferred from Sequence Orthology
more info
 
dinitrosyl-iron complex binding ISO
Inferred from Sequence Orthology
more info
 
drug binding ISO
Inferred from Sequence Orthology
more info
 
glutathione binding ISO
Inferred from Sequence Orthology
more info
 
glutathione peroxidase activity ISO
Inferred from Sequence Orthology
more info
 
glutathione transferase activity IDA
Inferred from Direct Assay
more info
PubMed 
glutathione transferase activity ISO
Inferred from Sequence Orthology
more info
 
kinase regulator activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein kinase binding ISO
Inferred from Sequence Orthology
more info
 
transferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
cellular response to lipopolysaccharide IDA
Inferred from Direct Assay
more info
PubMed 
common myeloid progenitor cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
glutathione metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of ERK1 and ERK2 cascade IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of I-kappaB kinase/NF-kappaB signaling IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of JUN kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of JUN kinase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of acute inflammatory response NAS
Non-traceable Author Statement
more info
PubMed 
negative regulation of apoptotic process TAS
Traceable Author Statement
more info
PubMed 
negative regulation of fibroblast proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of interleukin-1 beta production IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of leukocyte proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of monocyte chemotactic protein-1 production IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of neutrophil aggregation NAS
Non-traceable Author Statement
more info
PubMed 
negative regulation of nitric-oxide synthase biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of peroxidase activity IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of stress-activated MAPK cascade IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of tumor necrosis factor production IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of superoxide anion generation IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of ERK1 and ERK2 cascade IDA
Inferred from Direct Assay
more info
PubMed 
regulation of stress-activated MAPK cascade IDA
Inferred from Direct Assay
more info
PubMed 
response to reactive oxygen species IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
TRAF2-GSTP1 complex ISO
Inferred from Sequence Orthology
more info
 
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
cytosol ISO
Inferred from Sequence Orthology
more info
 
mitochondrion ISO
Inferred from Sequence Orthology
more info
 
nucleus ISO
Inferred from Sequence Orthology
more info
 
plasma membrane ISO
Inferred from Sequence Orthology
more info
 
protein-containing complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
glutathione S-transferase P 1
Names
GST YF-YF
GST class-pi
GST-piB
Gst p-1
gst P1
preadipocyte growth factor
NP_038569.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_013541.1NP_038569.1  glutathione S-transferase P 1

    See identical proteins and their annotated locations for NP_038569.1

    Status: VALIDATED

    Source sequence(s)
    D30687
    Consensus CDS
    CCDS29411.1
    UniProtKB/Swiss-Prot
    P19157
    Related
    ENSMUSP00000129565.1, ENSMUST00000169613.3
    Conserved Domains (3) summary
    PTZ00057
    Location:6196
    PTZ00057; glutathione s-transferase; Provisional
    cd03210
    Location:84210
    GST_C_Pi; C-terminal, alpha helical domain of Class Pi Glutathione S-transferases
    cd03076
    Location:376
    GST_N_Pi; GST_N family, Class Pi subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens, ...

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p4 C57BL/6J

Genomic

  1. NC_000085.6 Reference GRCm38.p4 C57BL/6J

    Range
    4035411..4037912 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCm38.p4 PATCHES

Genomic

  1. NW_004058054.1 Reference GRCm38.p4 PATCHES

    Range
    21426..23927 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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