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Gsta3 glutathione S-transferase, alpha 3 [ Mus musculus (house mouse) ]

Gene ID: 14859, updated on 12-May-2024

Summary

Official Symbol
Gsta3provided by MGI
Official Full Name
glutathione S-transferase, alpha 3provided by MGI
Primary source
MGI:MGI:95856
See related
Ensembl:ENSMUSG00000025934 AllianceGenome:MGI:95856
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Gst2-3
Summary
Enables glutathione transferase activity. Acts upstream of or within aflatoxin catabolic process and ureteric bud development. Predicted to be located in cytoplasm. Predicted to be active in cytosol. Is expressed in several structures, including alimentary system; liver; nervous system; nose; and urinary system. Orthologous to human GSTA3 (glutathione S-transferase alpha 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in liver E18 (RPKM 172.7), liver adult (RPKM 140.8) and 8 other tissues See more
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Genomic context

See Gsta3 in Genome Data Viewer
Location:
1 A4; 1 6.5 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (21310837..21335885)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (21240565..21265575)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene translocating chain-associating membrane protein 2 Neighboring gene STARR-positive B cell enhancer mm9_chr1:21030259-21030560 Neighboring gene STARR-seq mESC enhancer starr_00399 Neighboring gene transmembrane protein 14A Neighboring gene STARR-seq mESC enhancer starr_00401 Neighboring gene STARR-seq mESC enhancer starr_00402 Neighboring gene predicted gene, 32947 Neighboring gene predicted gene 28836 Neighboring gene STARR-seq mESC enhancer starr_00405 Neighboring gene STARR-seq mESC enhancer starr_00406 Neighboring gene predicted pseudogene 7094 Neighboring gene predicted gene 4956

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Gene trapped (1) 
  • Targeted (2)  1 citation

Pathways from PubChem

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables glutathione transferase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables glutathione transferase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within aflatoxin catabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in glutathione metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within lipid metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in ureteric bud development IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in xenobiotic metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
glutathione S-transferase A3
Names
GST class-alpha member 3
glutathione S-transferase Ya3
glutathione S-transferase Yc
NP_001070821.1
NP_001275546.1
NP_001407119.1
NP_001407120.1
NP_001407121.1
NP_001407122.1
NP_001407123.1
NP_001407124.1
NP_034486.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001077353.3NP_001070821.1  glutathione S-transferase A3 isoform a

    See identical proteins and their annotated locations for NP_001070821.1

    Status: VALIDATED

    Source sequence(s)
    AC163025
    Consensus CDS
    CCDS14847.1
    UniProtKB/Swiss-Prot
    P30115, Q544Y6
    UniProtKB/TrEMBL
    Q9DCU1
    Related
    ENSMUSP00000113262.2, ENSMUST00000121676.8
    Conserved Domains (3) summary
    PTZ00057
    Location:1198
    PTZ00057; glutathione s-transferase; Provisional
    cd03208
    Location:86220
    GST_C_Alpha; C-terminal, alpha helical domain of Class Alpha Glutathione S-transferases
    cd03077
    Location:482
    GST_N_Alpha; GST_N family, Class Alpha subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens, ...
  2. NM_001288617.2NP_001275546.1  glutathione S-transferase A3 isoform b

    Status: VALIDATED

    Source sequence(s)
    AC163025
    Conserved Domains (2) summary
    cd03208
    Location:36170
    GST_C_Alpha; C-terminal, alpha helical domain of Class Alpha Glutathione S-transferases
    cl00388
    Location:132
    Thioredoxin_like; Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold
  3. NM_001420190.1NP_001407119.1  glutathione S-transferase A3 isoform c

    Status: VALIDATED

    Source sequence(s)
    AC163025
  4. NM_001420191.1NP_001407120.1  glutathione S-transferase A3 isoform c

    Status: VALIDATED

    Source sequence(s)
    AC163025
  5. NM_001420192.1NP_001407121.1  glutathione S-transferase A3 isoform d

    Status: VALIDATED

    Source sequence(s)
    AC163025
  6. NM_001420193.1NP_001407122.1  glutathione S-transferase A3 isoform b

    Status: VALIDATED

    Source sequence(s)
    AC163025
  7. NM_001420194.1NP_001407123.1  glutathione S-transferase A3 isoform b

    Status: VALIDATED

    Source sequence(s)
    AC163025
  8. NM_001420195.1NP_001407124.1  glutathione S-transferase A3 isoform b

    Status: VALIDATED

    Source sequence(s)
    AC163025
  9. NM_010356.5NP_034486.2  glutathione S-transferase A3 isoform a

    See identical proteins and their annotated locations for NP_034486.2

    Status: VALIDATED

    Source sequence(s)
    AC163025
    Consensus CDS
    CCDS14847.1
    UniProtKB/Swiss-Prot
    P30115, Q544Y6
    UniProtKB/TrEMBL
    Q9DCU1
    Related
    ENSMUSP00000027067.9, ENSMUST00000027067.15
    Conserved Domains (3) summary
    PTZ00057
    Location:1198
    PTZ00057; glutathione s-transferase; Provisional
    cd03208
    Location:86220
    GST_C_Alpha; C-terminal, alpha helical domain of Class Alpha Glutathione S-transferases
    cd03077
    Location:482
    GST_N_Alpha; GST_N family, Class Alpha subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens, ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    21310837..21335885
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)