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Grm8 glutamate receptor, metabotropic 8 [ Mus musculus (house mouse) ]

Gene ID: 14823, updated on 1-Mar-2024

Summary

Official Symbol
Grm8provided by MGI
Official Full Name
glutamate receptor, metabotropic 8provided by MGI
Primary source
MGI:MGI:1351345
See related
Ensembl:ENSMUSG00000024211 AllianceGenome:MGI:1351345
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
GluR8; Gprc1h; mGluR8; A230002O04
Summary
Enables group III metabotropic glutamate receptor activity. Predicted to be involved in several processes, including adenylate cyclase-inhibiting G protein-coupled glutamate receptor signaling pathway; detection of mechanical stimulus involved in sensory perception of pain; and modulation of chemical synaptic transmission. Predicted to act upstream of or within signal transduction. Predicted to be located in neuron projection; neuronal cell body; and presynaptic membrane. Predicted to be integral component of plasma membrane. Is expressed in several structures, including eye; gonad; ileum; liver and biliary system; and nervous system. Human ortholog(s) of this gene implicated in attention deficit hyperactivity disorder; autistic disorder; and schizophrenia. Orthologous to human GRM8 (glutamate metabotropic receptor 8). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in frontal lobe adult (RPKM 2.3), CNS E18 (RPKM 1.6) and 6 other tissues See more
Orthologs
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Genomic context

See Grm8 in Genome Data Viewer
Location:
6 A3.1- A3.2; 6 11.97 cM
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (27275120..28135094, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (27275121..28135146, complement)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_15389 Neighboring gene STARR-seq mESC enhancer starr_15390 Neighboring gene predicted gene, 30779 Neighboring gene STARR-seq mESC enhancer starr_15392 Neighboring gene STARR-seq mESC enhancer starr_15393 Neighboring gene STARR-seq mESC enhancer starr_15396 Neighboring gene STARR-seq mESC enhancer starr_15397 Neighboring gene predicted gene, 38778 Neighboring gene STARR-seq mESC enhancer starr_15399 Neighboring gene STARR-seq mESC enhancer starr_15400 Neighboring gene STARR-seq mESC enhancer starr_15401 Neighboring gene STARR-seq mESC enhancer starr_15402 Neighboring gene STARR-seq mESC enhancer starr_15403 Neighboring gene predicted gene, 26310 Neighboring gene STARR-seq mESC enhancer starr_15404 Neighboring gene microRNA 592 Neighboring gene STARR-seq mESC enhancer starr_15405 Neighboring gene STARR-seq mESC enhancer starr_15406 Neighboring gene RIKEN cDNA 6530409C15 gene Neighboring gene predicted gene, 52896 Neighboring gene STARR-seq mESC enhancer starr_15407 Neighboring gene STARR-seq mESC enhancer starr_15408 Neighboring gene zinc finger protein 800 Neighboring gene kelch domain containing pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (4)  1 citation
  • Endonuclease-mediated (2) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables G protein-coupled receptor activity ISO
Inferred from Sequence Orthology
more info
 
enables glutamate receptor activity ISO
Inferred from Sequence Orthology
more info
 
enables group III metabotropic glutamate receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables group III metabotropic glutamate receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
enables group III metabotropic glutamate receptor activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in G protein-coupled glutamate receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within adenylate cyclase-inhibiting G protein-coupled glutamate receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in adenylate cyclase-inhibiting G protein-coupled glutamate receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in chemical synaptic transmission ISO
Inferred from Sequence Orthology
more info
 
involved_in chemical synaptic transmission TAS
Traceable Author Statement
more info
PubMed 
involved_in detection of mechanical stimulus involved in sensory perception of pain ISO
Inferred from Sequence Orthology
more info
 
involved_in presynaptic modulation of chemical synaptic transmission ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of neurotransmitter secretion ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of synaptic transmission, glutamatergic IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within response to stimulus IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within signal transduction IEA
Inferred from Electronic Annotation
more info
 
involved_in synaptic transmission, glutamatergic ISO
Inferred from Sequence Orthology
more info
 
involved_in synaptic transmission, glutamatergic TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
is_active_in GABA-ergic synapse ISO
Inferred from Sequence Orthology
more info
 
is_active_in glutamatergic synapse ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in neuronal cell body ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane TAS
Traceable Author Statement
more info
PubMed 
is_active_in presynaptic active zone membrane ISO
Inferred from Sequence Orthology
more info
 
located_in presynaptic membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
metabotropic glutamate receptor 8
Names
G protein coupled receptor, family C, group 1, member H

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001311072.2NP_001298001.1  metabotropic glutamate receptor 8 isoform 2 precursor

    See identical proteins and their annotated locations for NP_001298001.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site in the 3' coding region, compared to variant 1. It encodes isoform 2, which is of the same size as isoform 1, but contains a distinct C-terminus. Variants 2, 5, 6, and 7 all encode the same isoform (2).
    Source sequence(s)
    AC035247, AC067970, AC068066, AC074223, AC079957, AC121497
    Consensus CDS
    CCDS80495.1
    UniProtKB/Swiss-Prot
    P47743, Q6B964
    UniProtKB/TrEMBL
    B7ZMR4
    Conserved Domains (3) summary
    cd15454
    Location:582892
    7tmC_mGluR8; metabotropic glutamate receptor 8 in group 3, member of the class C family of seven-transmembrane G protein-coupled receptors
    cd06376
    Location:40504
    PBP1_mGluR_groupIII; ligand-binding domain of the group III metabotropic glutamate receptor
    pfam07562
    Location:512562
    NCD3G; Nine Cysteines Domain of family 3 GPCR
  2. NM_001361125.2NP_001348054.1  metabotropic glutamate receptor 8 isoform 1 precursor

    Status: VALIDATED

    Source sequence(s)
    AC035247, AC067970, AC068066, AC074223, AC079957, AC121497
    Consensus CDS
    CCDS39443.1
    UniProtKB/TrEMBL
    Q05BD6
    Conserved Domains (3) summary
    cd15454
    Location:582892
    7tmC_mGluR8; metabotropic glutamate receptor 8 in group 3, member of the class C family of seven-transmembrane G protein-coupled receptors
    pfam07562
    Location:512562
    NCD3G; Nine Cysteines Domain of family 3 GPCR
    cd06376
    Location:40504
    PBP1_mGluR_groupIII; ligand-binding domain of the group III metabotropic glutamate receptor
  3. NM_001409900.1NP_001396829.1  metabotropic glutamate receptor 8 isoform 1 precursor

    Status: VALIDATED

    Source sequence(s)
    AC035247, AC067970, AC068066, AC074223, AC079957, AC121497
    UniProtKB/TrEMBL
    Q05BD6
    Related
    ENSMUSP00000110979.3, ENSMUST00000115324.9
  4. NM_001409901.1NP_001396830.1  metabotropic glutamate receptor 8 isoform 2 precursor

    Status: VALIDATED

    Source sequence(s)
    AC035247, AC067970, AC068066, AC074223, AC079957, AC121497
    UniProtKB/Swiss-Prot
    P47743, Q6B964
    UniProtKB/TrEMBL
    B7ZMR4
    Related
    ENSMUSP00000087998.4, ENSMUST00000090512.10
  5. NM_001409903.1NP_001396832.1  metabotropic glutamate receptor 8 isoform 2 precursor

    Status: VALIDATED

    Source sequence(s)
    AC035247, AC067970, AC068066, AC074223, AC079957, AC121497
    UniProtKB/Swiss-Prot
    P47743, Q6B964
    UniProtKB/TrEMBL
    B7ZMR4
  6. NM_001409904.1NP_001396833.1  metabotropic glutamate receptor 8 isoform 2 precursor

    Status: VALIDATED

    Source sequence(s)
    AC035247, AC067970, AC068066, AC074223, AC079957, AC121497
    UniProtKB/Swiss-Prot
    P47743, Q6B964
    UniProtKB/TrEMBL
    B7ZMR4
  7. NM_001409905.1NP_001396834.1  metabotropic glutamate receptor 8 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC035247, AC068066, AC074223, AC121497
  8. NM_001409906.1NP_001396835.1  metabotropic glutamate receptor 8 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC035247, AC068066, AC074223, AC121497
  9. NM_001409907.1NP_001396836.1  metabotropic glutamate receptor 8 isoform 5 precursor

    Status: VALIDATED

    Source sequence(s)
    AC035247, AC067970, AC079957, AC121497
  10. NM_001409908.1NP_001396837.1  metabotropic glutamate receptor 8 isoform 5 precursor

    Status: VALIDATED

    Source sequence(s)
    AC035247, AC067970, AC079957, AC121497
  11. NM_001409909.1NP_001396838.1  metabotropic glutamate receptor 8 isoform 5 precursor

    Status: VALIDATED

    Source sequence(s)
    AC035247, AC067970, AC079957, AC121497
  12. NM_001409910.1NP_001396839.1  metabotropic glutamate receptor 8 isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC035247, AC121497
  13. NM_001409911.1NP_001396840.1  metabotropic glutamate receptor 8 isoform 7

    Status: VALIDATED

    Source sequence(s)
    AC035247, AC115890, AC121497
  14. NM_001409912.1NP_001396841.1  metabotropic glutamate receptor 8 isoform 8

    Status: VALIDATED

    Source sequence(s)
    AC035247, AC068066, AC074223, AC115890, AC121497
  15. NM_001409913.1NP_001396842.1  metabotropic glutamate receptor 8 isoform 9

    Status: VALIDATED

    Source sequence(s)
    AC035247, AC121497
  16. NM_008174.4NP_032200.2  metabotropic glutamate receptor 8 isoform 1 precursor

    See identical proteins and their annotated locations for NP_032200.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes isoform 1. Variants 1, 3, and 4 all encode the same isoform (1).
    Source sequence(s)
    AC035247, AC067970, AC068066, AC074223, AC079957, AC121497
    Consensus CDS
    CCDS39443.1
    UniProtKB/TrEMBL
    Q05BD6
    Related
    ENSMUSP00000110978.2, ENSMUST00000115323.8
    Conserved Domains (3) summary
    cd15454
    Location:582892
    7tmC_mGluR8; metabotropic glutamate receptor 8 in group 3, member of the class C family of seven-transmembrane G protein-coupled receptors
    pfam07562
    Location:512562
    NCD3G; Nine Cysteines Domain of family 3 GPCR
    cd06376
    Location:40504
    PBP1_mGluR_groupIII; ligand-binding domain of the group III metabotropic glutamate receptor

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    27275120..28135094 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006504991.4XP_006505054.1  metabotropic glutamate receptor 8 isoform X2

    See identical proteins and their annotated locations for XP_006505054.1

    UniProtKB/TrEMBL
    Q05BD6
    Conserved Domains (3) summary
    cd15454
    Location:582892
    7tmC_mGluR8; metabotropic glutamate receptor 8 in group 3, member of the class C family of seven-transmembrane G protein-coupled receptors
    pfam07562
    Location:512562
    NCD3G; Nine Cysteines Domain of family 3 GPCR
    cd06376
    Location:40504
    PBP1_mGluR_groupIII; ligand-binding domain of the group III metabotropic glutamate receptor
  2. XM_006504990.5XP_006505053.1  metabotropic glutamate receptor 8 isoform X2

    See identical proteins and their annotated locations for XP_006505053.1

    UniProtKB/TrEMBL
    Q05BD6
    Conserved Domains (3) summary
    cd15454
    Location:582892
    7tmC_mGluR8; metabotropic glutamate receptor 8 in group 3, member of the class C family of seven-transmembrane G protein-coupled receptors
    pfam07562
    Location:512562
    NCD3G; Nine Cysteines Domain of family 3 GPCR
    cd06376
    Location:40504
    PBP1_mGluR_groupIII; ligand-binding domain of the group III metabotropic glutamate receptor
  3. XM_030255175.2XP_030111035.1  metabotropic glutamate receptor 8 isoform X3

    Conserved Domains (1) summary
    cl10011
    Location:40385
    Periplasmic_Binding_Protein_type1; Type 1 periplasmic binding fold superfamily