Format

Send to:

Choose Destination

GRM8 glutamate metabotropic receptor 8 [ Homo sapiens (human) ]

Gene ID: 2918, updated on 1-Jun-2020

Summary

Official Symbol
GRM8provided by HGNC
Official Full Name
glutamate metabotropic receptor 8provided by HGNC
Primary source
HGNC:HGNC:4600
See related
Ensembl:ENSG00000179603 MIM:601116
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GLUR8; mGlu8; GPRC1H; MGLUR8
Summary
L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]
Expression
Biased expression in brain (RPKM 1.2), testis (RPKM 1.0) and 9 other tissues See more
Orthologs

Genomic context

See GRM8 in Genome Data Viewer
Location:
7q31.33
Exon count:
24
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 7 NC_000007.14 (126438598..127252941, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (126078652..126892428, complement)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105375487 Neighboring gene uncharacterized LOC105375488 Neighboring gene uncharacterized LOC101928357 Neighboring gene poly(A) binding protein cytoplasmic 4 pseudogene Neighboring gene uncharacterized LOC107986843 Neighboring gene microRNA 592 Neighboring gene GRM8 antisense RNA 1 Neighboring gene PRELI domain containing 3B pseudogene 10 Neighboring gene zinc finger protein 800

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
A genome-wide association study of carotid atherosclerosis in HIV-infected men.
NHGRI GWA Catalog
Chemerin, a novel adipokine in the regulation of angiogenesis.
NHGRI GWA Catalog
Genome-wide association scan of trait depression.
NHGRI GWA Catalog
Salt-inducible kinase 3, SIK3, is a new gene associated with hearing.
NHGRI GWA Catalog

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ41058, MGC126724

Gene Ontology Provided by GOA

Function Evidence Code Pubs
G protein-coupled receptor activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
glutamate receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
glutamate receptor activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
group III metabotropic glutamate receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
integral component of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
metabotropic glutamate receptor 8
Names
glutamate receptor, metabotropic 8

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029532.1 RefSeqGene

    Range
    5001..818777
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_000845.3NP_000836.2  metabotropic glutamate receptor 8 isoform a precursor

    See identical proteins and their annotated locations for NP_000836.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1), as well as variants 4 and 5, encodes isoform a.
    Source sequence(s)
    AC000099, AC000363, AC000367, AC000369, AC000370, AC002057, AC002083, AC002424, AC002533
    Consensus CDS
    CCDS5794.1
    UniProtKB/Swiss-Prot
    O00222
    Related
    ENSP00000344173.2, ENST00000339582.7
    Conserved Domains (4) summary
    cd06376
    Location:44504
    PBP1_mGluR_groupIII; Ligand-binding domain of the group III metabotropic glutamate receptor
    pfam00003
    Location:595840
    7tm_3; 7 transmembrane sweet-taste receptor of 3 GCPR
    pfam01094
    Location:74478
    ANF_receptor; Receptor family ligand binding region
    pfam07562
    Location:514560
    NCD3G; Nine Cysteines Domain of family 3 GPCR
  2. NM_001127323.1NP_001120795.1  metabotropic glutamate receptor 8 isoform b precursor

    See identical proteins and their annotated locations for NP_001120795.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate donor splice site at the penultimate exon compared to transcript variant 1, resulting in an isoform (b) of the same length, but with 16 different amino acids at the C-terminus compared to isoform a. This variant was designated as HmGluR8b by Malherbe et al, 1999 (PMID:10216218). Variants 2 and 6 both encode the same isoform (b).
    Source sequence(s)
    AJ236921, AK315203, BG202742, BG211606
    Consensus CDS
    CCDS47696.1
    UniProtKB/Swiss-Prot
    O00222
    Related
    ENSP00000351142.3, ENST00000358373.7
    Conserved Domains (4) summary
    cd06376
    Location:44504
    PBP1_mGluR_groupIII; Ligand-binding domain of the group III metabotropic glutamate receptor
    pfam00003
    Location:595840
    7tm_3; 7 transmembrane sweet-taste receptor of 3 GCPR
    pfam01094
    Location:74478
    ANF_receptor; Receptor family ligand binding region
    pfam07562
    Location:514560
    NCD3G; Nine Cysteines Domain of family 3 GPCR
  3. NM_001371083.1NP_001358012.1  metabotropic glutamate receptor 8 isoform a precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4), as well as variants 1 and 5, encodes isoform a.
    Source sequence(s)
    AC000099, AC000363, AC000367, AC000369, AC000370, AC002057, AC002083, AC002424, AC002533, KF458593
  4. NM_001371084.1NP_001358013.1  metabotropic glutamate receptor 8 isoform a precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5), as well as variants 1 and 4, encodes isoform a.
    Source sequence(s)
    AC000099, AC000363, AC000367, AC000369, AC000370, AC002057, AC002083, AC002424, AC002533
  5. NM_001371085.1NP_001358014.1  metabotropic glutamate receptor 8 isoform b precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6), as well as variant 2, encodes isoform b.
    Source sequence(s)
    AC000099, AC000363, AC000367, AC000369, AC000370, AC002057, AC002083, AC002424, AC002533
    Related
    ENSP00000419832.1, ENST00000472701.5
  6. NM_001371086.1NP_001358015.1  metabotropic glutamate receptor 8 isoform c precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7) encodes the longest isoform (c).
    Source sequence(s)
    AC000099, AC000363, AC000367, AC000369, AC000370, AC002057, AC002083, AC002424, AC002533
  7. NM_001371087.1NP_001358016.1  metabotropic glutamate receptor 8 isoform d

    Status: REVIEWED

    Source sequence(s)
    AC000363, AC000367, AC000369, AC000370, AC002057, AC002083, AC002424, AC002533
  8. NM_001371088.1NP_001358017.1  metabotropic glutamate receptor 8 isoform e precursor

    Status: REVIEWED

    Source sequence(s)
    AC000099, AC000363, AC000367, AC002424, AC002497, AC002533

RNA

  1. NR_028041.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) contains an additional exon in the central coding region that results in a frameshift, compared to transcript variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD). This variant was designated as HmGluR8c by Malherbe et al, 1999 (PMID:10216218).
    Source sequence(s)
    AJ236922, AK315203, BC093725, BG202742, BG211606
    Related
    ENST00000341617.7
  2. NR_163849.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC000099, AC000363, AC000367, AC000369, AC000370, AC002057, AC002083, AC002424, AC002533
  3. NR_163850.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC000363, AC000367, AC000369, AC000370, AC002057, AC002083, AC002424, AC002533

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p13 Primary Assembly

    Range
    126438598..127252941 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017012077.1XP_016867566.1  metabotropic glutamate receptor 8 isoform X5

  2. XM_017012078.1XP_016867567.1  metabotropic glutamate receptor 8 isoform X5

  3. XM_017012075.1XP_016867564.1  metabotropic glutamate receptor 8 isoform X5

  4. XM_017012076.1XP_016867565.1  metabotropic glutamate receptor 8 isoform X5

  5. XM_017012079.1XP_016867568.1  metabotropic glutamate receptor 8 isoform X5

  6. XM_011516094.1XP_011514396.1  metabotropic glutamate receptor 8 isoform X3

    Conserved Domains (4) summary
    pfam00003
    Location:434679
    7tm_3; 7 transmembrane sweet-taste receptor of 3 GCPR
    pfam01094
    Location:9317
    ANF_receptor; Receptor family ligand binding region
    pfam07562
    Location:353399
    NCD3G; Nine Cysteines Domain of family 3 GPCR
    cl10011
    Location:9343
    Periplasmic_Binding_Protein_Type_1; Type 1 periplasmic binding fold superfamily
  7. XM_011516103.2XP_011514405.1  metabotropic glutamate receptor 8 isoform X7

    See identical proteins and their annotated locations for XP_011514405.1

    Conserved Domains (3) summary
    pfam07562
    Location:235283
    NCD3G; Nine Cysteines Domain of family 3 GPCR
    cd15454
    Location:303613
    7tmC_mGluR8; metabotropic glutamate receptor 8 in group 3, member of the class C family of seven-transmembrane G protein-coupled receptors
    cl10011
    Location:1225
    Periplasmic_Binding_Protein_Type_1; Type 1 periplasmic binding fold superfamily
  8. XM_011516101.2XP_011514403.1  metabotropic glutamate receptor 8 isoform X6

    See identical proteins and their annotated locations for XP_011514403.1

    Conserved Domains (4) summary
    pfam00003
    Location:390635
    7tm_3; 7 transmembrane sweet-taste receptor of 3 GCPR
    pfam01094
    Location:1273
    ANF_receptor; Receptor family ligand binding region
    pfam07562
    Location:309355
    NCD3G; Nine Cysteines Domain of family 3 GPCR
    cl10011
    Location:1299
    Periplasmic_Binding_Protein_Type_1; Type 1 periplasmic binding fold superfamily
  9. XM_011516102.2XP_011514404.1  metabotropic glutamate receptor 8 isoform X6

    See identical proteins and their annotated locations for XP_011514404.1

    Conserved Domains (4) summary
    pfam00003
    Location:390635
    7tm_3; 7 transmembrane sweet-taste receptor of 3 GCPR
    pfam01094
    Location:1273
    ANF_receptor; Receptor family ligand binding region
    pfam07562
    Location:309355
    NCD3G; Nine Cysteines Domain of family 3 GPCR
    cl10011
    Location:1299
    Periplasmic_Binding_Protein_Type_1; Type 1 periplasmic binding fold superfamily
  10. XM_011516095.2XP_011514397.1  metabotropic glutamate receptor 8 isoform X4

    Conserved Domains (4) summary
    pfam00003
    Location:401646
    7tm_3; 7 transmembrane sweet-taste receptor of 3 GCPR
    pfam01094
    Location:2284
    ANF_receptor; Receptor family ligand binding region
    pfam07562
    Location:320366
    NCD3G; Nine Cysteines Domain of family 3 GPCR
    cl10011
    Location:1310
    Periplasmic_Binding_Protein_Type_1; Type 1 periplasmic binding fold superfamily
  11. XM_024446736.1XP_024302504.1  metabotropic glutamate receptor 8 isoform X7

    Conserved Domains (3) summary
    pfam07562
    Location:235283
    NCD3G; Nine Cysteines Domain of family 3 GPCR
    cd15454
    Location:303613
    7tmC_mGluR8; metabotropic glutamate receptor 8 in group 3, member of the class C family of seven-transmembrane G protein-coupled receptors
    cl10011
    Location:1225
    Periplasmic_Binding_Protein_Type_1; Type 1 periplasmic binding fold superfamily
  12. XM_017012080.1XP_016867569.1  metabotropic glutamate receptor 8 isoform X7

    Conserved Domains (3) summary
    pfam07562
    Location:235283
    NCD3G; Nine Cysteines Domain of family 3 GPCR
    cd15454
    Location:303613
    7tmC_mGluR8; metabotropic glutamate receptor 8 in group 3, member of the class C family of seven-transmembrane G protein-coupled receptors
    cl10011
    Location:1225
    Periplasmic_Binding_Protein_Type_1; Type 1 periplasmic binding fold superfamily
  13. XM_011516108.2XP_011514410.1  metabotropic glutamate receptor 8 isoform X8

    Conserved Domains (3) summary
    pfam00003
    Location:239484
    7tm_3; 7 transmembrane sweet-taste receptor of 3 GCPR
    pfam07562
    Location:158204
    NCD3G; Nine Cysteines Domain of family 3 GPCR
    cl10011
    Location:30148
    Periplasmic_Binding_Protein_Type_1; Type 1 periplasmic binding fold superfamily
Support Center