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GRM8 glutamate metabotropic receptor 8 [ Homo sapiens (human) ]

Gene ID: 2918, updated on 17-Jun-2019

Summary

Official Symbol
GRM8provided by HGNC
Official Full Name
glutamate metabotropic receptor 8provided by HGNC
Primary source
HGNC:HGNC:4600
See related
Ensembl:ENSG00000179603 MIM:601116
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GLUR8; mGlu8; GPRC1H; MGLUR8
Summary
L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]
Expression
Biased expression in brain (RPKM 1.2), testis (RPKM 1.0) and 9 other tissues See more
Orthologs

Genomic context

See GRM8 in Genome Data Viewer
Location:
7q31.33
Exon count:
23
Annotation release Status Assembly Chr Location
109.20190607 current GRCh38.p13 (GCF_000001405.39) 7 NC_000007.14 (126438598..127253293, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (126078652..126892428, complement)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105375487 Neighboring gene uncharacterized LOC105375488 Neighboring gene uncharacterized LOC101928357 Neighboring gene poly(A) binding protein cytoplasmic 4 pseudogene Neighboring gene uncharacterized LOC107986843 Neighboring gene microRNA 592 Neighboring gene uncharacterized LOC101928333 Neighboring gene PRELI domain containing 3B pseudogene 10 Neighboring gene zinc finger protein 800

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

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Pathways from BioSystems

  • Class C/3 (Metabotropic glutamate/pheromone receptors), organism-specific biosystem (from REACTOME)
    Class C/3 (Metabotropic glutamate/pheromone receptors), organism-specific biosystemThe class C G-protein-coupled receptors are a class of G-protein coupled receptors that include the metabotropic glutamate receptors and several additional receptors (Brauner-Osborne H et al, 2007). ...
  • G alpha (i) signalling events, organism-specific biosystem (from REACTOME)
    G alpha (i) signalling events, organism-specific biosystemThe classical signalling mechanism for G alpha (i) is inhibition of the cAMP dependent pathway through inhibition of adenylate cyclase. Decreased production of cAMP from ATP results in decreased act...
  • GPCR downstream signaling, organism-specific biosystem (from REACTOME)
    GPCR downstream signaling, organism-specific biosystemG protein-coupled receptors (GPCRs) are classically defined as the receptor, G-protein and downstream effectors, the alpha subunit of the G-protein being the primary signaling molecule. However, it h...
  • GPCR ligand binding, organism-specific biosystem (from REACTOME)
    GPCR ligand binding, organism-specific biosystemThere are more than 800 G-protein coupled receptor (GPCRs) in the human genome, making it the largest receptor superfamily. GPCRs are also the largest class of drug targets, involved in virtually all...
  • GPCRs, Class C Metabotropic glutamate, pheromone, organism-specific biosystem (from WikiPathways)
    GPCRs, Class C Metabotropic glutamate, pheromone, organism-specific biosystemThis pathway was created using the GPCRDB (Horn et al., 1998), http://www.gpcr.org/7tm/ (originally at http://www.cmbi.kun.nl/7tm/). The groupings are based on the GPCR phylogenetic tree available fr...
  • GPCRs, Other, organism-specific biosystem (from WikiPathways)
    GPCRs, Other, organism-specific biosystemThis pathway was created using the GPCRDB (Horn et al., 1998), http://www.gpcr.org/7tm/ (originally at http://www.cmbi.kun.nl/7tm/). The groupings are based on the GPCR phylogenetic tree available fr...
  • Glutamatergic synapse, organism-specific biosystem (from KEGG)
    Glutamatergic synapse, organism-specific biosystemGlutamate is the major excitatory neurotransmitter in the mammalian central nervous system(CNS). Glutamate is packaged into synaptic vesicles in the presynaptic terminal. Once released into the synap...
  • Glutamatergic synapse, conserved biosystem (from KEGG)
    Glutamatergic synapse, conserved biosystemGlutamate is the major excitatory neurotransmitter in the mammalian central nervous system(CNS). Glutamate is packaged into synaptic vesicles in the presynaptic terminal. Once released into the synap...
  • Neuroactive ligand-receptor interaction, organism-specific biosystem (from KEGG)
    Neuroactive ligand-receptor interaction, organism-specific biosystem
    Neuroactive ligand-receptor interaction
  • Neuroactive ligand-receptor interaction, conserved biosystem (from KEGG)
    Neuroactive ligand-receptor interaction, conserved biosystem
    Neuroactive ligand-receptor interaction
  • Phospholipase D signaling pathway, organism-specific biosystem (from KEGG)
    Phospholipase D signaling pathway, organism-specific biosystemPhospholipase D (PLD) is an essential enzyme responsible for the production of the lipid second messenger phosphatidic acid (PA), which is involved in fundamental cellular processes, including membra...
  • Phospholipase D signaling pathway, conserved biosystem (from KEGG)
    Phospholipase D signaling pathway, conserved biosystemPhospholipase D (PLD) is an essential enzyme responsible for the production of the lipid second messenger phosphatidic acid (PA), which is involved in fundamental cellular processes, including membra...
  • Signal Transduction, organism-specific biosystem (from REACTOME)
    Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
  • Signaling by GPCR, organism-specific biosystem (from REACTOME)
    Signaling by GPCR, organism-specific biosystemG protein-coupled receptors (GPCRs; 7TM receptors; seven transmembrane domain receptors; heptahelical receptors; G protein-linked receptors [GPLR]) are the largest family of transmembrane receptors i...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ41058, MGC126724

Gene Ontology Provided by GOA

Function Evidence Code Pubs
G protein-coupled receptor activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
glutamate receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
glutamate receptor activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
integral component of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 
presynaptic membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
metabotropic glutamate receptor 8
Names
glutamate receptor, metabotropic 8

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029532.1 RefSeqGene

    Range
    5001..818777
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_000845.2NP_000836.2  metabotropic glutamate receptor 8 isoform a precursor

    See identical proteins and their annotated locations for NP_000836.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes isoform a.
    Source sequence(s)
    AK315203, BC093725, BG202742, BG211606
    Consensus CDS
    CCDS5794.1
    UniProtKB/Swiss-Prot
    O00222
    Conserved Domains (4) summary
    cd06376
    Location:44504
    PBP1_mGluR_groupIII; Ligand-binding domain of the group III metabotropic glutamate receptor
    pfam00003
    Location:595840
    7tm_3; 7 transmembrane sweet-taste receptor of 3 GCPR
    pfam01094
    Location:74478
    ANF_receptor; Receptor family ligand binding region
    pfam07562
    Location:514560
    NCD3G; Nine Cysteines Domain of family 3 GPCR
  2. NM_001127323.1NP_001120795.1  metabotropic glutamate receptor 8 isoform b precursor

    See identical proteins and their annotated locations for NP_001120795.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate donor splice site at the penultimate exon compared to transcript variant 1, resulting in an isoform (b) of the same length, but with 16 different amino acids at the C-terminus compared to isoform a. This variant was designated as HmGluR8b by Malherbe et al, 1999 (PMID:10216218).
    Source sequence(s)
    AJ236921, AK315203, BG202742, BG211606
    Consensus CDS
    CCDS47696.1
    UniProtKB/Swiss-Prot
    O00222
    Related
    ENSP00000351142.3, ENST00000358373.7
    Conserved Domains (4) summary
    cd06376
    Location:44504
    PBP1_mGluR_groupIII; Ligand-binding domain of the group III metabotropic glutamate receptor
    pfam00003
    Location:595840
    7tm_3; 7 transmembrane sweet-taste receptor of 3 GCPR
    pfam01094
    Location:74478
    ANF_receptor; Receptor family ligand binding region
    pfam07562
    Location:514560
    NCD3G; Nine Cysteines Domain of family 3 GPCR

RNA

  1. NR_028041.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) contains an additional exon in the central coding region that results in a frameshift, compared to transcript variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD). This variant was designated as HmGluR8c by Malherbe et al, 1999 (PMID:10216218).
    Source sequence(s)
    AJ236922, AK315203, BC093725, BG202742, BG211606
    Related
    ENST00000341617.7

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p13 Primary Assembly

    Range
    126438598..127253293 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011516091.2XP_011514393.1  metabotropic glutamate receptor 8 isoform X1

    See identical proteins and their annotated locations for XP_011514393.1

    UniProtKB/Swiss-Prot
    O00222
    Related
    ENSP00000344173.2, ENST00000339582.6
    Conserved Domains (4) summary
    cd06376
    Location:44504
    PBP1_mGluR_groupIII; Ligand-binding domain of the group III metabotropic glutamate receptor
    pfam00003
    Location:595840
    7tm_3; 7 transmembrane sweet-taste receptor of 3 GCPR
    pfam01094
    Location:74478
    ANF_receptor; Receptor family ligand binding region
    pfam07562
    Location:514560
    NCD3G; Nine Cysteines Domain of family 3 GPCR
  2. XM_011516092.3XP_011514394.1  metabotropic glutamate receptor 8 isoform X2

    See identical proteins and their annotated locations for XP_011514394.1

    UniProtKB/Swiss-Prot
    O00222
    Related
    ENSP00000419832.1, ENST00000472701.5
    Conserved Domains (4) summary
    cd06376
    Location:44504
    PBP1_mGluR_groupIII; Ligand-binding domain of the group III metabotropic glutamate receptor
    pfam00003
    Location:595840
    7tm_3; 7 transmembrane sweet-taste receptor of 3 GCPR
    pfam01094
    Location:74478
    ANF_receptor; Receptor family ligand binding region
    pfam07562
    Location:514560
    NCD3G; Nine Cysteines Domain of family 3 GPCR
  3. XM_006715938.4XP_006716001.1  metabotropic glutamate receptor 8 isoform X1

    See identical proteins and their annotated locations for XP_006716001.1

    UniProtKB/Swiss-Prot
    O00222
    Conserved Domains (4) summary
    cd06376
    Location:44504
    PBP1_mGluR_groupIII; Ligand-binding domain of the group III metabotropic glutamate receptor
    pfam00003
    Location:595840
    7tm_3; 7 transmembrane sweet-taste receptor of 3 GCPR
    pfam01094
    Location:74478
    ANF_receptor; Receptor family ligand binding region
    pfam07562
    Location:514560
    NCD3G; Nine Cysteines Domain of family 3 GPCR
  4. XM_017012074.1XP_016867563.1  metabotropic glutamate receptor 8 isoform X1

    UniProtKB/Swiss-Prot
    O00222
    Conserved Domains (4) summary
    cd06376
    Location:44504
    PBP1_mGluR_groupIII; Ligand-binding domain of the group III metabotropic glutamate receptor
    pfam00003
    Location:595840
    7tm_3; 7 transmembrane sweet-taste receptor of 3 GCPR
    pfam01094
    Location:74478
    ANF_receptor; Receptor family ligand binding region
    pfam07562
    Location:514560
    NCD3G; Nine Cysteines Domain of family 3 GPCR
  5. XM_017012077.1XP_016867566.1  metabotropic glutamate receptor 8 isoform X5

  6. XM_017012078.1XP_016867567.1  metabotropic glutamate receptor 8 isoform X5

  7. XM_017012075.1XP_016867564.1  metabotropic glutamate receptor 8 isoform X5

  8. XM_017012076.1XP_016867565.1  metabotropic glutamate receptor 8 isoform X5

  9. XM_017012079.1XP_016867568.1  metabotropic glutamate receptor 8 isoform X5

  10. XM_011516094.1XP_011514396.1  metabotropic glutamate receptor 8 isoform X3

    Conserved Domains (4) summary
    pfam00003
    Location:434679
    7tm_3; 7 transmembrane sweet-taste receptor of 3 GCPR
    pfam01094
    Location:9317
    ANF_receptor; Receptor family ligand binding region
    pfam07562
    Location:353399
    NCD3G; Nine Cysteines Domain of family 3 GPCR
    cl10011
    Location:9343
    Periplasmic_Binding_Protein_Type_1; Type 1 periplasmic binding fold superfamily
  11. XM_011516103.2XP_011514405.1  metabotropic glutamate receptor 8 isoform X7

    See identical proteins and their annotated locations for XP_011514405.1

    Conserved Domains (3) summary
    pfam07562
    Location:235283
    NCD3G; Nine Cysteines Domain of family 3 GPCR
    cd15454
    Location:303613
    7tmC_mGluR8; metabotropic glutamate receptor 8 in group 3, member of the class C family of seven-transmembrane G protein-coupled receptors
    cl10011
    Location:1225
    Periplasmic_Binding_Protein_Type_1; Type 1 periplasmic binding fold superfamily
  12. XM_011516101.2XP_011514403.1  metabotropic glutamate receptor 8 isoform X6

    See identical proteins and their annotated locations for XP_011514403.1

    Conserved Domains (4) summary
    pfam00003
    Location:390635
    7tm_3; 7 transmembrane sweet-taste receptor of 3 GCPR
    pfam01094
    Location:1273
    ANF_receptor; Receptor family ligand binding region
    pfam07562
    Location:309355
    NCD3G; Nine Cysteines Domain of family 3 GPCR
    cl10011
    Location:1299
    Periplasmic_Binding_Protein_Type_1; Type 1 periplasmic binding fold superfamily
  13. XM_011516102.2XP_011514404.1  metabotropic glutamate receptor 8 isoform X6

    See identical proteins and their annotated locations for XP_011514404.1

    Conserved Domains (4) summary
    pfam00003
    Location:390635
    7tm_3; 7 transmembrane sweet-taste receptor of 3 GCPR
    pfam01094
    Location:1273
    ANF_receptor; Receptor family ligand binding region
    pfam07562
    Location:309355
    NCD3G; Nine Cysteines Domain of family 3 GPCR
    cl10011
    Location:1299
    Periplasmic_Binding_Protein_Type_1; Type 1 periplasmic binding fold superfamily
  14. XM_011516095.2XP_011514397.1  metabotropic glutamate receptor 8 isoform X4

    Conserved Domains (4) summary
    pfam00003
    Location:401646
    7tm_3; 7 transmembrane sweet-taste receptor of 3 GCPR
    pfam01094
    Location:2284
    ANF_receptor; Receptor family ligand binding region
    pfam07562
    Location:320366
    NCD3G; Nine Cysteines Domain of family 3 GPCR
    cl10011
    Location:1310
    Periplasmic_Binding_Protein_Type_1; Type 1 periplasmic binding fold superfamily
  15. XM_024446736.1XP_024302504.1  metabotropic glutamate receptor 8 isoform X7

    Conserved Domains (3) summary
    pfam07562
    Location:235283
    NCD3G; Nine Cysteines Domain of family 3 GPCR
    cd15454
    Location:303613
    7tmC_mGluR8; metabotropic glutamate receptor 8 in group 3, member of the class C family of seven-transmembrane G protein-coupled receptors
    cl10011
    Location:1225
    Periplasmic_Binding_Protein_Type_1; Type 1 periplasmic binding fold superfamily
  16. XM_017012080.1XP_016867569.1  metabotropic glutamate receptor 8 isoform X7

    Conserved Domains (3) summary
    pfam07562
    Location:235283
    NCD3G; Nine Cysteines Domain of family 3 GPCR
    cd15454
    Location:303613
    7tmC_mGluR8; metabotropic glutamate receptor 8 in group 3, member of the class C family of seven-transmembrane G protein-coupled receptors
    cl10011
    Location:1225
    Periplasmic_Binding_Protein_Type_1; Type 1 periplasmic binding fold superfamily
  17. XM_011516108.2XP_011514410.1  metabotropic glutamate receptor 8 isoform X8

    Conserved Domains (3) summary
    pfam00003
    Location:239484
    7tm_3; 7 transmembrane sweet-taste receptor of 3 GCPR
    pfam07562
    Location:158204
    NCD3G; Nine Cysteines Domain of family 3 GPCR
    cl10011
    Location:30148
    Periplasmic_Binding_Protein_Type_1; Type 1 periplasmic binding fold superfamily
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