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GRM8 glutamate metabotropic receptor 8 [ Homo sapiens (human) ]

Gene ID: 2918, updated on 26-Oct-2022

Summary

Official Symbol
GRM8provided by HGNC
Official Full Name
glutamate metabotropic receptor 8provided by HGNC
Primary source
HGNC:HGNC:4600
See related
Ensembl:ENSG00000179603 MIM:601116; AllianceGenome:HGNC:4600
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GLUR8; mGlu8; GPRC1H; MGLUR8
Summary
L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]
Expression
Biased expression in brain (RPKM 1.2), testis (RPKM 1.0) and 9 other tissues See more
Orthologs
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Genomic context

See GRM8 in Genome Data Viewer
Location:
7q31.33
Exon count:
26
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (126438598..127252941, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (127750296..128564614, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (126078652..126892995, complement)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105375487 Neighboring gene uncharacterized LOC105375488 Neighboring gene uncharacterized LOC101928357 Neighboring gene poly(A) binding protein cytoplasmic 4 pseudogene Neighboring gene uncharacterized LOC107986843 Neighboring gene uncharacterized LOC124901742 Neighboring gene microRNA 592 Neighboring gene GRM8 antisense RNA 1 Neighboring gene PRELI domain containing 3B pseudogene 10 Neighboring gene zinc finger protein 800

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

EBI GWAS Catalog

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EBI GWAS Catalog
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EBI GWAS Catalog
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EBI GWAS Catalog

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ41058, MGC126724

General protein information

Preferred Names
metabotropic glutamate receptor 8
Names
glutamate receptor, metabotropic 8

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029532.2 RefSeqGene

    Range
    5000..819343
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_000845.3NP_000836.2  metabotropic glutamate receptor 8 isoform a precursor

    See identical proteins and their annotated locations for NP_000836.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1), as well as variants 4 and 5, encodes isoform a.
    Source sequence(s)
    AC000099, AC000363, AC000367, AC000369, AC000370, AC002057, AC002083, AC002424, AC002533
    Consensus CDS
    CCDS5794.1
    UniProtKB/Swiss-Prot
    O00222, Q6J165
    Related
    ENSP00000344173.2, ENST00000339582.7
    Conserved Domains (3) summary
    cd15454
    Location:582892
    7tmC_mGluR8; metabotropic glutamate receptor 8 in group 3, member of the class C family of seven-transmembrane G protein-coupled receptors
    pfam07562
    Location:512562
    NCD3G; Nine Cysteines Domain of family 3 GPCR
    cd06376
    Location:40504
    PBP1_mGluR_groupIII; ligand-binding domain of the group III metabotropic glutamate receptor
  2. NM_001127323.1NP_001120795.1  metabotropic glutamate receptor 8 isoform b precursor

    See identical proteins and their annotated locations for NP_001120795.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate donor splice site at the penultimate exon compared to transcript variant 1, resulting in an isoform (b) of the same length, but with 16 different amino acids at the C-terminus compared to isoform a. This variant was designated as HmGluR8b by Malherbe et al, 1999 (PMID:10216218). Variants 2 and 6 both encode the same isoform (b).
    Source sequence(s)
    AJ236921, AK315203, BG202742, BG211606
    Consensus CDS
    CCDS47696.1
    UniProtKB/Swiss-Prot
    O00222
    Related
    ENSP00000351142.3, ENST00000358373.7
    Conserved Domains (3) summary
    cd15454
    Location:582892
    7tmC_mGluR8; metabotropic glutamate receptor 8 in group 3, member of the class C family of seven-transmembrane G protein-coupled receptors
    pfam07562
    Location:512562
    NCD3G; Nine Cysteines Domain of family 3 GPCR
    cd06376
    Location:40504
    PBP1_mGluR_groupIII; ligand-binding domain of the group III metabotropic glutamate receptor
  3. NM_001371083.1NP_001358012.1  metabotropic glutamate receptor 8 isoform a precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4), as well as variants 1 and 5, encodes isoform a.
    Source sequence(s)
    AC000099, AC000363, AC000367, AC000369, AC000370, AC002057, AC002083, AC002424, AC002533, KF458593
    Consensus CDS
    CCDS5794.1
    UniProtKB/Swiss-Prot
    Q6J165
    Conserved Domains (3) summary
    cd15454
    Location:582892
    7tmC_mGluR8; metabotropic glutamate receptor 8 in group 3, member of the class C family of seven-transmembrane G protein-coupled receptors
    pfam07562
    Location:512562
    NCD3G; Nine Cysteines Domain of family 3 GPCR
    cd06376
    Location:40504
    PBP1_mGluR_groupIII; ligand-binding domain of the group III metabotropic glutamate receptor
  4. NM_001371084.1NP_001358013.1  metabotropic glutamate receptor 8 isoform a precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5), as well as variants 1 and 4, encodes isoform a.
    Source sequence(s)
    AC000099, AC000363, AC000367, AC000369, AC000370, AC002057, AC002083, AC002424, AC002533
    Consensus CDS
    CCDS5794.1
    UniProtKB/Swiss-Prot
    Q6J165
    Conserved Domains (3) summary
    cd15454
    Location:582892
    7tmC_mGluR8; metabotropic glutamate receptor 8 in group 3, member of the class C family of seven-transmembrane G protein-coupled receptors
    pfam07562
    Location:512562
    NCD3G; Nine Cysteines Domain of family 3 GPCR
    cd06376
    Location:40504
    PBP1_mGluR_groupIII; ligand-binding domain of the group III metabotropic glutamate receptor
  5. NM_001371085.1NP_001358014.1  metabotropic glutamate receptor 8 isoform b precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6), as well as variant 2, encodes isoform b.
    Source sequence(s)
    AC000099, AC000363, AC000367, AC000369, AC000370, AC002057, AC002083, AC002424, AC002533
    Consensus CDS
    CCDS47696.1
    Related
    ENSP00000419832.1, ENST00000472701.5
    Conserved Domains (3) summary
    cd15454
    Location:582892
    7tmC_mGluR8; metabotropic glutamate receptor 8 in group 3, member of the class C family of seven-transmembrane G protein-coupled receptors
    pfam07562
    Location:512562
    NCD3G; Nine Cysteines Domain of family 3 GPCR
    cd06376
    Location:40504
    PBP1_mGluR_groupIII; ligand-binding domain of the group III metabotropic glutamate receptor
  6. NM_001371086.1NP_001358015.1  metabotropic glutamate receptor 8 isoform c precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7) encodes the longest isoform (c).
    Source sequence(s)
    AC000099, AC000363, AC000367, AC000369, AC000370, AC002057, AC002083, AC002424, AC002533
  7. NM_001371087.1NP_001358016.1  metabotropic glutamate receptor 8 isoform d

    Status: REVIEWED

    Source sequence(s)
    AC000363, AC000367, AC000369, AC000370, AC002057, AC002083, AC002424, AC002533
    Conserved Domains (3) summary
    cd15454
    Location:377687
    7tmC_mGluR8; metabotropic glutamate receptor 8 in group 3, member of the class C family of seven-transmembrane G protein-coupled receptors
    pfam07562
    Location:307357
    NCD3G; Nine Cysteines Domain of family 3 GPCR
    cl10011
    Location:1299
    Periplasmic_Binding_Protein_type1; Type 1 periplasmic binding fold superfamily
  8. NM_001371088.1NP_001358017.1  metabotropic glutamate receptor 8 isoform e precursor

    Status: REVIEWED

    Source sequence(s)
    AC000099, AC000363, AC000367, AC002424, AC002497, AC002533

RNA

  1. NR_028041.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) contains an additional exon in the central coding region that results in a frameshift, compared to transcript variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD). This variant was designated as HmGluR8c by Malherbe et al, 1999 (PMID:10216218).
    Source sequence(s)
    AJ236922, AK315203, BC093725, BG202742, BG211606
    Related
    ENST00000341617.7
  2. NR_163849.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC000099, AC000363, AC000367, AC000369, AC000370, AC002057, AC002083, AC002424, AC002533
  3. NR_163850.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC000363, AC000367, AC000369, AC000370, AC002057, AC002083, AC002424, AC002533

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

    Range
    126438598..127252941 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047420269.1XP_047276225.1  metabotropic glutamate receptor 8 isoform X1

  2. XM_047420271.1XP_047276227.1  metabotropic glutamate receptor 8 isoform X3

  3. XM_017012077.2XP_016867566.1  metabotropic glutamate receptor 8 isoform X3

    Conserved Domains (3) summary
    cd15454
    Location:377687
    7tmC_mGluR8; metabotropic glutamate receptor 8 in group 3, member of the class C family of seven-transmembrane G protein-coupled receptors
    pfam07562
    Location:307357
    NCD3G; Nine Cysteines Domain of family 3 GPCR
    cl10011
    Location:1299
    Periplasmic_Binding_Protein_type1; Type 1 periplasmic binding fold superfamily
  4. XM_047420272.1XP_047276228.1  metabotropic glutamate receptor 8 isoform X3

  5. XM_017012078.2XP_016867567.1  metabotropic glutamate receptor 8 isoform X3

    Conserved Domains (3) summary
    cd15454
    Location:377687
    7tmC_mGluR8; metabotropic glutamate receptor 8 in group 3, member of the class C family of seven-transmembrane G protein-coupled receptors
    pfam07562
    Location:307357
    NCD3G; Nine Cysteines Domain of family 3 GPCR
    cl10011
    Location:1299
    Periplasmic_Binding_Protein_type1; Type 1 periplasmic binding fold superfamily
  6. XM_047420270.1XP_047276226.1  metabotropic glutamate receptor 8 isoform X2

  7. XM_017012075.2XP_016867564.1  metabotropic glutamate receptor 8 isoform X3

    Conserved Domains (3) summary
    cd15454
    Location:377687
    7tmC_mGluR8; metabotropic glutamate receptor 8 in group 3, member of the class C family of seven-transmembrane G protein-coupled receptors
    pfam07562
    Location:307357
    NCD3G; Nine Cysteines Domain of family 3 GPCR
    cl10011
    Location:1299
    Periplasmic_Binding_Protein_type1; Type 1 periplasmic binding fold superfamily
  8. XM_017012076.2XP_016867565.1  metabotropic glutamate receptor 8 isoform X3

    Conserved Domains (3) summary
    cd15454
    Location:377687
    7tmC_mGluR8; metabotropic glutamate receptor 8 in group 3, member of the class C family of seven-transmembrane G protein-coupled receptors
    pfam07562
    Location:307357
    NCD3G; Nine Cysteines Domain of family 3 GPCR
    cl10011
    Location:1299
    Periplasmic_Binding_Protein_type1; Type 1 periplasmic binding fold superfamily
  9. XM_047420276.1XP_047276232.1  metabotropic glutamate receptor 8 isoform X3

  10. XM_017012079.2XP_016867568.1  metabotropic glutamate receptor 8 isoform X3

    Conserved Domains (3) summary
    cd15454
    Location:377687
    7tmC_mGluR8; metabotropic glutamate receptor 8 in group 3, member of the class C family of seven-transmembrane G protein-coupled receptors
    pfam07562
    Location:307357
    NCD3G; Nine Cysteines Domain of family 3 GPCR
    cl10011
    Location:1299
    Periplasmic_Binding_Protein_type1; Type 1 periplasmic binding fold superfamily
  11. XM_047420275.1XP_047276231.1  metabotropic glutamate receptor 8 isoform X4

  12. XM_047420274.1XP_047276230.1  metabotropic glutamate receptor 8 isoform X4

  13. XM_047420273.1XP_047276229.1  metabotropic glutamate receptor 8 isoform X4

  14. XM_047420277.1XP_047276233.1  metabotropic glutamate receptor 8 isoform X5

RNA

  1. XR_007060010.1 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060931.1 Alternate T2T-CHM13v2.0

    Range
    127750296..128564614 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)