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Gria2 glutamate receptor, ionotropic, AMPA2 (alpha 2) [ Mus musculus (house mouse) ]

Gene ID: 14800, updated on 22-Jan-2023

Summary

Official Symbol
Gria2provided by MGI
Official Full Name
glutamate receptor, ionotropic, AMPA2 (alpha 2)provided by MGI
Primary source
MGI:MGI:95809
See related
Ensembl:ENSMUSG00000033981 AllianceGenome:MGI:95809
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
GluA2; Glur2; GluR-B; Glur-2; gluR-K2
Summary
Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. This gene product belongs to a family of glutamate receptors that are sensitive to alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA), and function as ligand-activated cation channels. These channels are assembled from 4 related subunits, Gria1-4. The subunit encoded by this gene (Gria2) is subject to RNA editing (CAG->CGG; Q->R) within the second transmembrane domain, which is thought to render the channel impermeable to Ca(2+). Alternative splicing, resulting in transcript variants encoding different isoforms, (including the flip and flop isoforms that vary in their signal transduction properties), has been noted for this gene. [provided by RefSeq, Jul 2008]
Expression
Biased expression in CNS E18 (RPKM 50.8), frontal lobe adult (RPKM 41.0) and 5 other tissues See more
Orthologs
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Genomic context

See Gria2 in Genome Data Viewer
Location:
3 E3; 3 35.5 cM
Exon count:
18
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (80588757..80711534, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (80681450..80804227, complement)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA A330069K06 gene Neighboring gene eukaryotic translation initiation factor 3, subunit M pseudogene Neighboring gene small nucleolar RNA SNORA48 Neighboring gene glycine receptor, beta subunit Neighboring gene polymerase (DNA directed), iota pseudogene Neighboring gene predicted gene, 54207

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables AMPA glutamate receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables AMPA glutamate receptor activity ISO
Inferred from Sequence Orthology
more info
 
enables ATPase binding ISO
Inferred from Sequence Orthology
more info
 
enables PDZ domain binding ISO
Inferred from Sequence Orthology
more info
 
enables SNARE binding ISO
Inferred from Sequence Orthology
more info
 
enables amyloid-beta binding ISO
Inferred from Sequence Orthology
more info
 
enables cytoskeletal protein binding ISO
Inferred from Sequence Orthology
more info
 
enables extracellularly glutamate-gated ion channel activity IDA
Inferred from Direct Assay
more info
PubMed 
enables glutamate receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables immunoglobulin binding ISO
Inferred from Sequence Orthology
more info
 
enables ionotropic glutamate receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
enables ionotropic glutamate receptor activity ISO
Inferred from Sequence Orthology
more info
 
enables ionotropic glutamate receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables kainate selective glutamate receptor activity ISO
Inferred from Sequence Orthology
more info
 
enables ligand-gated monoatomic ion channel activity IEA
Inferred from Electronic Annotation
more info
 
enables ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential ISO
Inferred from Sequence Orthology
more info
 
enables monoatomic ion channel activity IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein kinase binding ISO
Inferred from Sequence Orthology
more info
 
enables protein-containing complex binding ISO
Inferred from Sequence Orthology
more info
 
enables scaffold protein binding ISO
Inferred from Sequence Orthology
more info
 
enables signaling receptor activity ISO
Inferred from Sequence Orthology
more info
 
enables transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential IDA
Inferred from Direct Assay
more info
PubMed 
enables transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in cellular response to brain-derived neurotrophic factor stimulus ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to glycine ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within chemical synaptic transmission IDA
Inferred from Direct Assay
more info
PubMed 
involved_in chemical synaptic transmission ISO
Inferred from Sequence Orthology
more info
 
involved_in establishment of protein localization ISO
Inferred from Sequence Orthology
more info
 
involved_in ionotropic glutamate receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in modulation of chemical synaptic transmission IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within monoatomic ion transport IEA
Inferred from Electronic Annotation
more info
 
involved_in monoatomic ion transport IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of synaptic transmission ISO
Inferred from Sequence Orthology
more info
 
involved_in protein tetramerization ISO
Inferred from Sequence Orthology
more info
 
involved_in receptor internalization ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of receptor recycling ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of synaptic transmission, glutamatergic ISO
Inferred from Sequence Orthology
more info
 
involved_in synaptic transmission, glutamatergic IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
part_of AMPA glutamate receptor complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of AMPA glutamate receptor complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of AMPA glutamate receptor complex ISO
Inferred from Sequence Orthology
more info
 
is_active_in Schaffer collateral - CA1 synapse IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in Schaffer collateral - CA1 synapse IMP
Inferred from Mutant Phenotype
more info
PubMed 
is_active_in Schaffer collateral - CA1 synapse ISO
Inferred from Sequence Orthology
more info
 
located_in asymmetric synapse ISO
Inferred from Sequence Orthology
more info
 
located_in axon ISO
Inferred from Sequence Orthology
more info
 
located_in cell surface ISO
Inferred from Sequence Orthology
more info
 
located_in dendrite IDA
Inferred from Direct Assay
more info
PubMed 
located_in dendrite ISO
Inferred from Sequence Orthology
more info
 
located_in dendrite cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in dendrite membrane ISO
Inferred from Sequence Orthology
more info
 
located_in dendritic shaft ISO
Inferred from Sequence Orthology
more info
 
is_active_in dendritic spine IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in dendritic spine ISO
Inferred from Sequence Orthology
more info
 
located_in dendritic spine head ISO
Inferred from Sequence Orthology
more info
 
located_in dendritic spine neck ISO
Inferred from Sequence Orthology
more info
 
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in glutamatergic synapse IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in glutamatergic synapse ISO
Inferred from Sequence Orthology
more info
 
located_in growth cone ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in membrane ISO
Inferred from Sequence Orthology
more info
 
located_in neuron projection IDA
Inferred from Direct Assay
more info
PubMed 
located_in neuronal cell body ISO
Inferred from Sequence Orthology
more info
 
located_in perikaryon ISO
Inferred from Sequence Orthology
more info
 
located_in perisynaptic space IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in postsynaptic density IDA
Inferred from Direct Assay
more info
PubMed 
located_in postsynaptic density ISO
Inferred from Sequence Orthology
more info
 
is_active_in postsynaptic density membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
is_active_in postsynaptic density membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in postsynaptic density membrane IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in postsynaptic density membrane ISO
Inferred from Sequence Orthology
more info
 
located_in postsynaptic membrane IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in postsynaptic membrane ISO
Inferred from Sequence Orthology
more info
 
located_in presynapse ISO
Inferred from Sequence Orthology
more info
 
is_active_in presynaptic active zone membrane ISO
Inferred from Sequence Orthology
more info
 
is_active_in presynaptic membrane ISO
Inferred from Sequence Orthology
more info
 
located_in presynaptic membrane ISO
Inferred from Sequence Orthology
more info
 
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
 
located_in somatodendritic compartment IDA
Inferred from Direct Assay
more info
PubMed 
located_in spine synapse ISO
Inferred from Sequence Orthology
more info
 
located_in synapse IDA
Inferred from Direct Assay
more info
PubMed 
located_in synapse ISO
Inferred from Sequence Orthology
more info
 
located_in synaptic membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in synaptic vesicle IDA
Inferred from Direct Assay
more info
PubMed 
located_in synaptic vesicle membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in synaptic vesicle membrane ISO
Inferred from Sequence Orthology
more info
 
located_in terminal bouton ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
glutamate receptor 2
Names
AMPA selective glutamate receptor
AMPA-selective glutamate receptor 2
glutamate receptor B
glutamate receptor ionotropic, AMPA 2

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001039195.3NP_001034284.2  glutamate receptor 2 isoform 3 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs at the 3' end compared to transcript variant 1, and encodes a shorter isoform (3) with a distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AC121908, AC163349
    Related
    ENSMUST00000194383.6
  2. NM_001083806.3NP_001077275.2  glutamate receptor 2 isoform 1 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes isoform 1 (also known as the flip isoform).
    Source sequence(s)
    AC121908, AC163349
    Consensus CDS
    CCDS38459.1
    UniProtKB/TrEMBL
    A0A8C6GH75, E9QKC0
    Related
    ENSMUSP00000103374.2, ENSMUST00000107745.8
    Conserved Domains (2) summary
    cd13715
    Location:413794
    PBP2_iGluR_AMPA; The ligand-binding domain of the AMPA (alpha-amino-3-hydroxyl-5-methyl-4-isoxazolepropionic acid) subtypes of ionotropic glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily
    cd06389
    Location:28398
    PBP1_iGluR_AMPA_GluR2; N-terminal leucine-isoleucine-valine binding protein (LIVBP)-like domain of the GluR2 subunit of the AMPA receptor
  3. NM_001357924.2NP_001344853.2  glutamate receptor 2 isoform 4 precursor

    Status: REVIEWED

    Source sequence(s)
    AC121908, AC163349
    Conserved Domains (2) summary
    cd13715
    Location:413794
    PBP2_iGluR_AMPA; The ligand-binding domain of the AMPA (alpha-amino-3-hydroxyl-5-methyl-4-isoxazolepropionic acid) subtypes of ionotropic glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily
    cd06389
    Location:28398
    PBP1_iGluR_AMPA_GluR2; N-terminal leucine-isoleucine-valine binding protein (LIVBP)-like domain of the GluR2 subunit of the AMPA receptor
  4. NM_001357927.2NP_001344856.2  glutamate receptor 2 isoform 5 precursor

    Status: REVIEWED

    Source sequence(s)
    AC121908, AC163349
    Conserved Domains (2) summary
    cd13715
    Location:413794
    PBP2_iGluR_AMPA; The ligand-binding domain of the AMPA (alpha-amino-3-hydroxyl-5-methyl-4-isoxazolepropionic acid) subtypes of ionotropic glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily
    cd06389
    Location:28398
    PBP1_iGluR_AMPA_GluR2; N-terminal leucine-isoleucine-valine binding protein (LIVBP)-like domain of the GluR2 subunit of the AMPA receptor
  5. NM_013540.4NP_038568.3  glutamate receptor 2 isoform 2 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate exon in the 3' coding region compared to transcript variant 1, and encodes an isoform (2, also known as the flop isoform) that is the same length as isoform 1, but with few amino acid differences.
    Source sequence(s)
    AC121908, AC163349
    Consensus CDS
    CCDS17423.1
    UniProtKB/TrEMBL
    A0A8C6GGW2, G5E8H1
    Related
    ENSMUSP00000074787.5, ENSMUST00000075316.10
    Conserved Domains (2) summary
    cd13715
    Location:413794
    PBP2_iGluR_AMPA; The ligand-binding domain of the AMPA (alpha-amino-3-hydroxyl-5-methyl-4-isoxazolepropionic acid) subtypes of ionotropic glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily
    cd06389
    Location:28398
    PBP1_iGluR_AMPA_GluR2; N-terminal leucine-isoleucine-valine binding protein (LIVBP)-like domain of the GluR2 subunit of the AMPA receptor

RNA

  1. NR_152147.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC121908, AC163349
  2. NR_152148.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC121908, AC163349
  3. NR_152149.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC121908, AC163349, AI841956

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    80588757..80711534 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006501014.4XP_006501077.1  glutamate receptor 2 isoform X1

    UniProtKB/TrEMBL
    A0A8C6MQY8
    Related
    ENSMUSP00000141447.2, ENSMUST00000192463.2
    Conserved Domains (2) summary
    cd13715
    Location:413794
    PBP2_iGluR_AMPA; The ligand-binding domain of the AMPA (alpha-amino-3-hydroxyl-5-methyl-4-isoxazolepropionic acid) subtypes of ionotropic glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily
    cd06389
    Location:28398
    PBP1_iGluR_AMPA_GluR2; N-terminal leucine-isoleucine-valine binding protein (LIVBP)-like domain of the GluR2 subunit of the AMPA receptor

RNA

  1. XR_004941283.1 RNA Sequence

  2. XR_003954287.1 RNA Sequence

  3. XR_004941289.1 RNA Sequence

  4. XR_375488.4 RNA Sequence

  5. XR_001783655.3 RNA Sequence

  6. XR_001783653.3 RNA Sequence

  7. XR_003954286.1 RNA Sequence

  8. XR_003954284.2 RNA Sequence

  9. XR_003954283.2 RNA Sequence

  10. XR_001783662.3 RNA Sequence

  11. XR_003954288.2 RNA Sequence

  12. XR_004941284.1 RNA Sequence

  13. XR_001783652.3 RNA Sequence

  14. XR_001783657.3 RNA Sequence

  15. XR_001783656.3 RNA Sequence

  16. XR_003954285.2 RNA Sequence

  17. XR_001783654.3 RNA Sequence

  18. XR_004941287.1 RNA Sequence

  19. XR_004941288.1 RNA Sequence

  20. XR_004941286.1 RNA Sequence

  21. XR_003954282.2 RNA Sequence

  22. XR_004941280.1 RNA Sequence

  23. XR_004941279.1 RNA Sequence

  24. XR_004941285.1 RNA Sequence

  25. XR_004941282.1 RNA Sequence

  26. XR_004941281.1 RNA Sequence