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GRIA2 glutamate ionotropic receptor AMPA type subunit 2 [ Homo sapiens (human) ]

Gene ID: 2891, updated on 6-May-2021

Summary

Official Symbol
GRIA2provided by HGNC
Official Full Name
glutamate ionotropic receptor AMPA type subunit 2provided by HGNC
Primary source
HGNC:HGNC:4572
See related
Ensembl:ENSG00000120251 MIM:138247
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GLUR2; GLURB; GluA2; HBGR2; NEDLIB; gluR-2; gluR-B; GluR-K2
Summary
Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. This gene product belongs to a family of glutamate receptors that are sensitive to alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA), and function as ligand-activated cation channels. These channels are assembled from 4 related subunits, GRIA1-4. The subunit encoded by this gene (GRIA2) is subject to RNA editing (CAG->CGG; Q->R) within the second transmembrane domain, which is thought to render the channel impermeable to Ca(2+). Human and animal studies suggest that pre-mRNA editing is essential for brain function, and defective GRIA2 RNA editing at the Q/R site may be relevant to amyotrophic lateral sclerosis (ALS) etiology. Alternative splicing, resulting in transcript variants encoding different isoforms, (including the flip and flop isoforms that vary in their signal transduction properties), has been noted for this gene. [provided by RefSeq, Jul 2008]
Expression
Restricted expression toward brain (RPKM 36.3) See more
Orthologs
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Genomic context

See GRIA2 in Genome Data Viewer
Location:
4q32.1
Exon count:
19
Annotation release Status Assembly Chr Location
109.20210226 current GRCh38.p13 (GCF_000001405.39) 4 NC_000004.12 (157220120..157370583)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (158141272..158287227)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene RNA, U6 small nuclear 582, pseudogene Neighboring gene chromatin accessibility complex subunit 1 pseudogene Neighboring gene uncharacterized LOC112268471 Neighboring gene uncharacterized LOC107986238 Neighboring gene long intergenic non-protein coding RNA 2433

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of glutamate receptor, ionotropic, AMPA 2 (GRIA2) by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables AMPA glutamate receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables AMPA glutamate receptor activity ISS
Inferred from Sequence or Structural Similarity
more info
 
contributes_to AMPA glutamate receptor activity NAS
Non-traceable Author Statement
more info
PubMed 
enables amyloid-beta binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables amyloid-beta binding NAS
Non-traceable Author Statement
more info
PubMed 
enables ionotropic glutamate receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
enables ligand-gated ion channel activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables signaling receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
part_of AMPA glutamate receptor complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of AMPA glutamate receptor complex ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in asymmetric synapse ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in dendrite ISS
Inferred from Sequence or Structural Similarity
more info
 
is_active_in dendritic spine IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in dendritic spine NAS
Non-traceable Author Statement
more info
PubMed 
located_in endocytic vesicle membrane TAS
Traceable Author Statement
more info
 
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
 
located_in excitatory synapse NAS
Non-traceable Author Statement
more info
PubMed 
located_in external side of plasma membrane TAS
Traceable Author Statement
more info
PubMed 
located_in integral component of plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in neuronal cell body ISS
Inferred from Sequence or Structural Similarity
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in plasma membrane TAS
Traceable Author Statement
more info
 
located_in postsynapse TAS
Traceable Author Statement
more info
PubMed 
located_in postsynaptic density ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in postsynaptic density membrane IEA
Inferred from Electronic Annotation
more info
 
located_in postsynaptic endocytic zone NAS
Non-traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
glutamate receptor 2
Names
AMPA-selective glutamate receptor 2
glutamate receptor, ionotropic, AMPA 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_000826.6NP_000817.5  glutamate receptor 2 isoform 1 precursor

    Status: REVIEWED

    Source sequence(s)
    AC079233, AC112240
    Consensus CDS
    CCDS3797.1
    Related
    ENSP00000296526.7, ENST00000296526.12
    Conserved Domains (2) summary
    cd13715
    Location:413794
    PBP2_iGluR_AMPA; The ligand-binding domain of the AMPA (alpha-amino-3-hydroxyl-5-methyl-4-isoxazolepropionic acid) subtypes of ionotropic glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily
    cd06389
    Location:28398
    PBP1_iGluR_AMPA_GluR2; N-terminal leucine-isoleucine-valine binding protein (LIVBP)-like domain of the GluR2 subunit of the AMPA receptor
  2. NM_001083619.3NP_001077088.2  glutamate receptor 2 isoform 2 precursor

    Status: REVIEWED

    Source sequence(s)
    AC079233, AC112240
    Consensus CDS
    CCDS43274.1
    Related
    ENSP00000264426.9, ENST00000264426.14
    Conserved Domains (2) summary
    cd13715
    Location:413794
    PBP2_iGluR_AMPA; The ligand-binding domain of the AMPA (alpha-amino-3-hydroxyl-5-methyl-4-isoxazolepropionic acid) subtypes of ionotropic glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily
    cd06389
    Location:28398
    PBP1_iGluR_AMPA_GluR2; N-terminal leucine-isoleucine-valine binding protein (LIVBP)-like domain of the GluR2 subunit of the AMPA receptor
  3. NM_001083620.3NP_001077089.2  glutamate receptor 2 isoform 3

    Status: REVIEWED

    Source sequence(s)
    AC079233, AC112240
    Consensus CDS
    CCDS43275.1
    Related
    ENSP00000377403.2, ENST00000393815.6
    Conserved Domains (2) summary
    cd13715
    Location:366747
    PBP2_iGluR_AMPA; The ligand-binding domain of the AMPA (alpha-amino-3-hydroxyl-5-methyl-4-isoxazolepropionic acid) subtypes of ionotropic glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily
    cl10011
    Location:1351
    Periplasmic_Binding_Protein_type1; Type 1 periplasmic binding fold superfamily
  4. NM_001379000.3NP_001365929.3  glutamate receptor 2 isoform 4

    Status: REVIEWED

    Source sequence(s)
    AC079233, AC112240
    Related
    ENSP00000318144.6, ENST00000323661.10
    Conserved Domains (2) summary
    cd13715
    Location:366747
    PBP2_iGluR_AMPA; The ligand-binding domain of the AMPA (alpha-amino-3-hydroxyl-5-methyl-4-isoxazolepropionic acid) subtypes of ionotropic glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily
    cl10011
    Location:1351
    Periplasmic_Binding_Protein_type1; Type 1 periplasmic binding fold superfamily
  5. NM_001379001.3NP_001365930.3  glutamate receptor 2 isoform 3

    Status: REVIEWED

    Source sequence(s)
    AC079233, AC112240
    Related
    ENSP00000426845.1, ENST00000507898.5
    Conserved Domains (2) summary
    cd13715
    Location:366747
    PBP2_iGluR_AMPA; The ligand-binding domain of the AMPA (alpha-amino-3-hydroxyl-5-methyl-4-isoxazolepropionic acid) subtypes of ionotropic glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily
    cl10011
    Location:1351
    Periplasmic_Binding_Protein_type1; Type 1 periplasmic binding fold superfamily

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210226

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p13 Primary Assembly

    Range
    157220120..157370583
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RNA

  1. XR_001741212.2 RNA Sequence

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