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GRIA2 glutamate ionotropic receptor AMPA type subunit 2 [ Homo sapiens (human) ]

Gene ID: 2891, updated on 1-Jun-2020

Summary

Official Symbol
GRIA2provided by HGNC
Official Full Name
glutamate ionotropic receptor AMPA type subunit 2provided by HGNC
Primary source
HGNC:HGNC:4572
See related
Ensembl:ENSG00000120251 MIM:138247
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GLUR2; GLURB; GluA2; HBGR2; gluR-2; gluR-B; GluR-K2
Summary
Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. This gene product belongs to a family of glutamate receptors that are sensitive to alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA), and function as ligand-activated cation channels. These channels are assembled from 4 related subunits, GRIA1-4. The subunit encoded by this gene (GRIA2) is subject to RNA editing (CAG->CGG; Q->R) within the second transmembrane domain, which is thought to render the channel impermeable to Ca(2+). Human and animal studies suggest that pre-mRNA editing is essential for brain function, and defective GRIA2 RNA editing at the Q/R site may be relevant to amyotrophic lateral sclerosis (ALS) etiology. Alternative splicing, resulting in transcript variants encoding different isoforms, (including the flip and flop isoforms that vary in their signal transduction properties), has been noted for this gene. [provided by RefSeq, Jul 2008]
Expression
Restricted expression toward brain (RPKM 36.3) See more
Orthologs

Genomic context

See GRIA2 in Genome Data Viewer
Location:
4q32.1
Exon count:
19
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 4 NC_000004.12 (157220120..157370583)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (158141736..158287227)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene RNA, U6 small nuclear 582, pseudogene Neighboring gene chromatin accessibility complex subunit 1 pseudogene Neighboring gene uncharacterized LOC112268471 Neighboring gene uncharacterized LOC107986238 Neighboring gene long intergenic non-protein coding RNA 2433

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of glutamate receptor, ionotropic, AMPA 2 (GRIA2) by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
AMPA glutamate receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
AMPA glutamate receptor activity ISS
Inferred from Sequence or Structural Similarity
more info
 
contributes_to AMPA glutamate receptor activity NAS
Non-traceable Author Statement
more info
PubMed 
amyloid-beta binding ISS
Inferred from Sequence or Structural Similarity
more info
 
amyloid-beta binding NAS
Non-traceable Author Statement
more info
PubMed 
glutamate receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
ionotropic glutamate receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
ligand-gated ion channel activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
signaling receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
chemical synaptic transmission TAS
Traceable Author Statement
more info
PubMed 
ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
ionotropic glutamate receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
modulation of chemical synaptic transmission IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of NMDA receptor activity TAS
Traceable Author Statement
more info
 
regulation of postsynaptic membrane potential IEA
Inferred from Electronic Annotation
more info
 
signal transduction TAS
Traceable Author Statement
more info
PubMed 
synaptic transmission, glutamatergic IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
synaptic transmission, glutamatergic TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
AMPA glutamate receptor complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
AMPA glutamate receptor complex ISS
Inferred from Sequence or Structural Similarity
more info
 
asymmetric synapse ISS
Inferred from Sequence or Structural Similarity
more info
 
dendrite ISS
Inferred from Sequence or Structural Similarity
more info
 
dendritic spine IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
dendritic spine NAS
Non-traceable Author Statement
more info
PubMed 
endocytic vesicle membrane TAS
Traceable Author Statement
more info
 
endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
 
excitatory synapse NAS
Non-traceable Author Statement
more info
PubMed 
external side of plasma membrane TAS
Traceable Author Statement
more info
PubMed 
integral component of plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
neuronal cell body ISS
Inferred from Sequence or Structural Similarity
more info
 
plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 
postsynapse TAS
Traceable Author Statement
more info
PubMed 
postsynaptic density ISS
Inferred from Sequence or Structural Similarity
more info
 
postsynaptic density membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
postsynaptic endocytic zone NAS
Non-traceable Author Statement
more info
PubMed 
postsynaptic membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
glutamate receptor 2
Names
AMPA-selective glutamate receptor 2
glutamate receptor B flip isoform
glutamate receptor, ionotropic, AMPA 2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_000826.6NP_000817.5  glutamate receptor 2 isoform 1 precursor

    Status: REVIEWED

    Source sequence(s)
    AC079233, AC112240
    Consensus CDS
    CCDS3797.1
    Related
    ENSP00000296526.7, ENST00000296526.12
  2. NM_001083619.3NP_001077088.2  glutamate receptor 2 isoform 2 precursor

    Status: REVIEWED

    Source sequence(s)
    AC079233, AC112240
    Consensus CDS
    CCDS43274.1
    Related
    ENSP00000264426.9, ENST00000264426.13
  3. NM_001083620.3NP_001077089.2  glutamate receptor 2 isoform 3

    Status: REVIEWED

    Source sequence(s)
    AC079233, AC112240
    Consensus CDS
    CCDS43275.1
    Related
    ENSP00000377403.2, ENST00000393815.6
  4. NM_001379000.3NP_001365929.3  glutamate receptor 2 isoform 4

    Status: REVIEWED

    Source sequence(s)
    AC079233, AC112240
  5. NM_001379001.3NP_001365930.3  glutamate receptor 2 isoform 3

    Status: REVIEWED

    Source sequence(s)
    AC079233, AC112240

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p13 Primary Assembly

    Range
    157220120..157370583
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RNA

  1. XR_001741212.2 RNA Sequence

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