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Grk4 G protein-coupled receptor kinase 4 [ Mus musculus (house mouse) ]

Gene ID: 14772, updated on 22-Jan-2023

Summary

Official Symbol
Grk4provided by MGI
Official Full Name
G protein-coupled receptor kinase 4provided by MGI
Primary source
MGI:MGI:95801
See related
Ensembl:ENSMUSG00000052783 AllianceGenome:MGI:95801
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
GRK; Gprk4; Gprk2l; A830025H08Rik
Summary
Predicted to enable rhodopsin kinase activity. Predicted to be involved in G protein-coupled receptor internalization and protein phosphorylation. Predicted to act upstream of or within phosphorylation. Predicted to be located in cytosol; dendrite; and neuronal cell body. Predicted to be active in cytoplasm. Is expressed in brain and testis. Human ortholog(s) of this gene implicated in essential hypertension. Orthologous to human GRK4 (G protein-coupled receptor kinase 4). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in testis adult (RPKM 7.6), bladder adult (RPKM 0.8) and 10 other tissues See more
Orthologs
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Genomic context

See Grk4 in Genome Data Viewer
Location:
5 B2; 5 17.91 cM
Exon count:
21
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (34817641..34912649)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (34660250..34755305)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene major facilitator superfamily domain containing 10 Neighboring gene NOP14 nucleolar protein Neighboring gene predicted gene 15522 Neighboring gene microRNA 467g Neighboring gene huntingtin Neighboring gene Myb/SANT-like DNA-binding domain containing 1

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (1) 
  • Endonuclease-mediated (1) 

Pathways from PubChem

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables G protein-coupled receptor kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables protein kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables rhodopsin kinase activity ISO
Inferred from Sequence Orthology
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in G protein-coupled receptor internalization ISO
Inferred from Sequence Orthology
more info
 
involved_in desensitization of G protein-coupled receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
 
involved_in protein phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in receptor internalization ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in dendrite ISO
Inferred from Sequence Orthology
more info
 
located_in neuronal cell body ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
G protein-coupled receptor kinase 4
Names
G protein-coupled receptor kinase 2, groucho gene related
g protein-coupled receptor kinase GRK4
NP_001074212.1
NP_062370.2
XP_006503805.1
XP_017176159.1
XP_017176160.1
XP_030109995.1
XP_030109996.1
XP_030109997.1
XP_030109998.1
XP_036020689.1
XP_036020690.1
XP_036020691.1
XP_036020692.1
XP_036020693.1
XP_036020694.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001080743.1NP_001074212.1  G protein-coupled receptor kinase 4 isoform 2

    See identical proteins and their annotated locations for NP_001074212.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate 3' exon structure and differs in the 3' UTR and the 3' coding region, compared to variant 1. It encodes isoform 2, which is shorter than isoform 1.
    Source sequence(s)
    AC151669, AK132685, BY719486
    Consensus CDS
    CCDS39070.1
    UniProtKB/Swiss-Prot
    O70291
    UniProtKB/TrEMBL
    Q8BP13
    Related
    ENSMUSP00000074223.5, ENSMUST00000074651.11
    Conserved Domains (1) summary
    cl02565
    Location:51145
    RGS; Regulator of G protein signaling (RGS) domain superfamily
  2. NM_019497.2NP_062370.2  G protein-coupled receptor kinase 4 isoform 1

    See identical proteins and their annotated locations for NP_062370.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AK132685, BY719486
    Consensus CDS
    CCDS19219.1
    UniProtKB/Swiss-Prot
    O70291, Q3V151
    Related
    ENSMUSP00000001112.8, ENSMUST00000001112.14
    Conserved Domains (3) summary
    smart00220
    Location:186448
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd05605
    Location:185469
    STKc_GRK4_like; Catalytic domain of G protein-coupled Receptor Kinase 4-like Serine/Threonine Kinases
    cl02565
    Location:51183
    RGS; Regulator of G protein signaling (RGS) domain superfamily

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    34817641..34912649
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036164798.1XP_036020691.1  G protein-coupled receptor kinase 4 isoform X6

    Conserved Domains (1) summary
    cl21453
    Location:1259
    PKc_like; Protein Kinases, catalytic domain
  2. XM_036164800.1XP_036020693.1  G protein-coupled receptor kinase 4 isoform X7

    Conserved Domains (2) summary
    cl02565
    Location:51183
    RGS; Regulator of G protein signaling (RGS) domain superfamily
    cl21453
    Location:185352
    PKc_like; Protein Kinases, catalytic domain
  3. XM_006503742.5XP_006503805.1  G protein-coupled receptor kinase 4 isoform X8

    Conserved Domains (2) summary
    cl02565
    Location:51183
    RGS; Regulator of G protein signaling (RGS) domain superfamily
    cl21453
    Location:185352
    PKc_like; Protein Kinases, catalytic domain
  4. XM_017320670.3XP_017176159.1  G protein-coupled receptor kinase 4 isoform X4

    Conserved Domains (2) summary
    cd05605
    Location:185468
    STKc_GRK4_like; Catalytic domain of G protein-coupled Receptor Kinase 4-like Serine/Threonine Kinases
    cl02565
    Location:51183
    RGS; Regulator of G protein signaling (RGS) domain superfamily
  5. XM_017320671.3XP_017176160.1  G protein-coupled receptor kinase 4 isoform X5

    Conserved Domains (3) summary
    cl02565
    Location:51183
    RGS; Regulator of G protein signaling (RGS) domain superfamily
    cl11395
    Location:373438
    Pkinase_C; Protein kinase C terminal domain
    cl21453
    Location:185393
    PKc_like; Protein Kinases, catalytic domain
  6. XM_036164796.1XP_036020689.1  G protein-coupled receptor kinase 4 isoform X1

    Conserved Domains (2) summary
    cd05605
    Location:185469
    STKc_GRK4_like; Catalytic domain of G protein-coupled Receptor Kinase 4-like Serine/Threonine Kinases
    cl02565
    Location:51183
    RGS; Regulator of G protein signaling (RGS) domain superfamily
  7. XM_030254136.2XP_030109996.1  G protein-coupled receptor kinase 4 isoform X6

    Conserved Domains (1) summary
    cl21453
    Location:1259
    PKc_like; Protein Kinases, catalytic domain
  8. XM_036164801.1XP_036020694.1  G protein-coupled receptor kinase 4 isoform X6

    Conserved Domains (1) summary
    cl21453
    Location:1259
    PKc_like; Protein Kinases, catalytic domain
  9. XM_036164797.1XP_036020690.1  G protein-coupled receptor kinase 4 isoform X2

    Conserved Domains (2) summary
    cd05605
    Location:146430
    STKc_GRK4_like; Catalytic domain of G protein-coupled Receptor Kinase 4-like Serine/Threonine Kinases
    cl02565
    Location:12144
    RGS; Regulator of G protein signaling (RGS) domain superfamily
  10. XM_030254135.2XP_030109995.1  G protein-coupled receptor kinase 4 isoform X3

    Conserved Domains (2) summary
    cd05605
    Location:145429
    STKc_GRK4_like; Catalytic domain of G protein-coupled Receptor Kinase 4-like Serine/Threonine Kinases
    cl02565
    Location:11143
    RGS; Regulator of G protein signaling (RGS) domain superfamily
  11. XM_030254137.2XP_030109997.1  G protein-coupled receptor kinase 4 isoform X6

    Conserved Domains (1) summary
    cl21453
    Location:1259
    PKc_like; Protein Kinases, catalytic domain
  12. XM_036164799.1XP_036020692.1  G protein-coupled receptor kinase 4 isoform X6

    Conserved Domains (1) summary
    cl21453
    Location:1259
    PKc_like; Protein Kinases, catalytic domain
  13. XM_030254138.1XP_030109998.1  G protein-coupled receptor kinase 4 isoform X6

    Conserved Domains (1) summary
    cl21453
    Location:1259
    PKc_like; Protein Kinases, catalytic domain

RNA

  1. XR_003955585.2 RNA Sequence

  2. XR_003955583.2 RNA Sequence