Format

Send to:

Choose Destination

PPM1N protein phosphatase, Mg2+/Mn2+ dependent 1N (putative) [ Homo sapiens (human) ]

Gene ID: 147699, updated on 13-Mar-2020

Summary

Official Symbol
PPM1Nprovided by HGNC
Official Full Name
protein phosphatase, Mg2+/Mn2+ dependent 1N (putative)provided by HGNC
Primary source
HGNC:HGNC:26845
See related
Ensembl:ENSG00000213889
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Expression
Broad expression in spleen (RPKM 1.5), lymph node (RPKM 0.6) and 20 other tissues See more
Orthologs

Genomic context

See PPM1N in Genome Data Viewer
Location:
19q13.32
Exon count:
4
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (45497964..45502694)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (46001731..46005768)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene FosB proto-oncogene, AP-1 transcription factor subunit Neighboring gene reticulon 2 Neighboring gene uncharacterized LOC107985314 Neighboring gene vasodilator stimulated phosphoprotein Neighboring gene uncharacterized LOC107985315 Neighboring gene outer mitochondrial membrane lipid metabolism regulator OPA3

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of protein phosphatase, Mg2+/Mn2+ dependent, 1N (PPM1N) by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells PubMed

Go to the HIV-1, Human Interaction Database

General gene information

Markers

Homology

Clone Names

  • FLJ40125

Gene Ontology Provided by GOA

Function Evidence Code Pubs
magnesium ion binding IEA
Inferred from Electronic Annotation
more info
 
magnesium-dependent protein serine/threonine phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
manganese ion binding IEA
Inferred from Electronic Annotation
more info
 
protein serine/threonine phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
negative regulation of I-kappaB kinase/NF-kappaB signaling IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of canonical Wnt signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein dephosphorylation IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
probable protein phosphatase 1N
NP_001073870.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001080401.1NP_001073870.1  probable protein phosphatase 1N

    See identical proteins and their annotated locations for NP_001073870.1

    Status: VALIDATED

    Source sequence(s)
    AC138534
    Consensus CDS
    CCDS46115.1
    UniProtKB/Swiss-Prot
    Q8N819
    Related
    ENSP00000397050.2, ENST00000451287.6
    Conserved Domains (2) summary
    cd00143
    Location:66326
    PP2Cc; Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence ...
    pfam07830
    Location:320394
    PP2C_C; Protein serine/threonine phosphatase 2C, C-terminal domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

    Range
    45497964..45502694
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RNA

  1. XR_002958254.1 RNA Sequence

  2. XR_001753603.2 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_178494.2: Suppressed sequence

    Description
    NM_178494.2: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
Support Center