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Got1 glutamic-oxaloacetic transaminase 1, soluble [ Mus musculus (house mouse) ]

Gene ID: 14718, updated on 18-Apr-2024

Summary

Official Symbol
Got1provided by MGI
Official Full Name
glutamic-oxaloacetic transaminase 1, solubleprovided by MGI
Primary source
MGI:MGI:95791
See related
Ensembl:ENSMUSG00000025190 AllianceGenome:MGI:95791
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
cCAT; Got-1; cAspAT
Summary
Enables L-aspartate:2-oxoglutarate aminotransferase activity and phosphatidylserine decarboxylase activity. Acts upstream of or within several processes, including dicarboxylic acid metabolic process; fatty acid homeostasis; and glycerol biosynthetic process. Located in cytosol. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; integumental system; and sensory organ. Human ortholog(s) of this gene implicated in amyloidosis; amyotrophic lateral sclerosis; pancreatic ductal adenocarcinoma; and transient cerebral ischemia. Orthologous to human GOT1 (glutamic-oxaloacetic transaminase 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in heart adult (RPKM 196.6), liver adult (RPKM 107.5) and 20 other tissues See more
Orthologs
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Genomic context

Location:
19 C3; 19 36.67 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (43488191..43514743, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (43499752..43524605, complement)

Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 38568 Neighboring gene STARR-seq mESC enhancer starr_46194 Neighboring gene cyclin M1 Neighboring gene STARR-seq mESC enhancer starr_46196 Neighboring gene STARR-positive B cell enhancer mm9_chr19:43592413-43592714 Neighboring gene STARR-positive B cell enhancer ABC_E1525 Neighboring gene STARR-positive B cell enhancer ABC_E1213 Neighboring gene translocase of inner mitochondrial membrane 23 homolog pseudogene Neighboring gene predicted gene, 34636

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (4)  1 citation
  • Targeted (2) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables L-aspartate:2-oxoglutarate aminotransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables L-aspartate:2-oxoglutarate aminotransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables L-aspartate:2-oxoglutarate aminotransferase activity ISO
Inferred from Sequence Orthology
more info
 
enables L-cysteine transaminase activity ISO
Inferred from Sequence Orthology
more info
 
enables carboxylic acid binding ISO
Inferred from Sequence Orthology
more info
 
enables catalytic activity IEA
Inferred from Electronic Annotation
more info
 
enables phosphatidylserine decarboxylase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables pyridoxal phosphate binding IEA
Inferred from Electronic Annotation
more info
 
enables transaminase activity IEA
Inferred from Electronic Annotation
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within Notch signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within amino acid biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
involved_in amino acid metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in aspartate biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within aspartate biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in aspartate catabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in aspartate metabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular response to mechanical stimulus ISO
Inferred from Sequence Orthology
more info
 
involved_in dicarboxylic acid metabolic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within fatty acid homeostasis IDA
Inferred from Direct Assay
more info
PubMed 
involved_in gluconeogenesis IDA
Inferred from Direct Assay
more info
PubMed 
involved_in gluconeogenesis ISO
Inferred from Sequence Orthology
more info
PubMed 
acts_upstream_of_or_within glutamate catabolic process to 2-oxoglutarate IDA
Inferred from Direct Assay
more info
PubMed 
involved_in glutamate catabolic process to 2-oxoglutarate ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within glutamate catabolic process to aspartate IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within glycerol biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in glycerol biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of collagen biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of cytosolic calcium ion concentration ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of mitochondrial depolarization ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within oxaloacetate metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in oxaloacetate metabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of transforming growth factor beta receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in response to transition metal nanoparticle ISO
Inferred from Sequence Orthology
more info
 
involved_in transdifferentiation ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in axon terminus ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in cytosol IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
aspartate aminotransferase, cytoplasmic
Names
cysteine aminotransferase, cytoplasmic
cysteine transaminase, cytoplasmic
cytosolic aspartate aminotransferase
glutamate oxaloacetate transaminase 1, soluble
transaminase A
NP_034454.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_010324.2NP_034454.2  aspartate aminotransferase, cytoplasmic

    See identical proteins and their annotated locations for NP_034454.2

    Status: VALIDATED

    Source sequence(s)
    AK146445, AK147807, AV574373, BY441762, CK334037
    Consensus CDS
    CCDS29832.1
    UniProtKB/Swiss-Prot
    P05201, Q3UJH8
    Related
    ENSMUSP00000026196.8, ENSMUST00000026196.14
    Conserved Domains (2) summary
    pfam00155
    Location:31405
    Aminotran_1_2; Aminotransferase class I and II
    cl18945
    Location:1413
    AAT_I; Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000085.7 Reference GRCm39 C57BL/6J

    Range
    43488191..43514743 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RNA

  1. XR_004940117.1 RNA Sequence