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GOT1 glutamic-oxaloacetic transaminase 1 [ Homo sapiens (human) ]

Gene ID: 2805, updated on 8-Oct-2018

Summary

Official Symbol
GOT1provided by HGNC
Official Full Name
glutamic-oxaloacetic transaminase 1provided by HGNC
Primary source
HGNC:HGNC:4432
See related
Ensembl:ENSG00000120053 MIM:138180; Vega:OTTHUMG00000018882
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
AST1; cCAT; GIG18; cAspAT; ASTQTL1
Summary
Glutamic-oxaloacetic transaminase is a pyridoxal phosphate-dependent enzyme which exists in cytoplasmic and mitochondrial forms, GOT1 and GOT2, respectively. GOT plays a role in amino acid metabolism and the urea and tricarboxylic acid cycles. The two enzymes are homodimeric and show close homology. [provided by RefSeq, Jul 2008]
Expression
Broad expression in heart (RPKM 196.1), liver (RPKM 87.7) and 14 other tissues See more
Orthologs

Genomic context

See GOT1 in Genome Data Viewer
Location:
10q24.2
Exon count:
9
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 10 NC_000010.11 (99396870..99430773, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (101156627..101190530, complement)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene Sharpr-MPRA regulatory region 10329 Neighboring gene cyclin and CBS domain divalent metal cation transport mediator 1 Neighboring gene uncharacterized LOC107984261 Neighboring gene uncharacterized LOC101927300 Neighboring gene long intergenic non-protein coding RNA 1475 Neighboring gene NK2 homeobox 3

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Aspartate aminotransferase, serum level of, quantitative trait locus 1
MedGen: C3280741 OMIM: 614419 GeneReviews: Not available
Compare labs

NHGRI GWAS Catalog

Description
A genome-wide scan of Ashkenazi Jewish Crohn's disease suggests novel susceptibility loci.
NHGRI GWA Catalog
Genome-wide association study identifies genetic variants in GOT1 determining serum aspartate aminotransferase levels.
NHGRI GWA Catalog
Genome-wide association study of liver enzymes in korean children.
NHGRI GWA Catalog

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
L-aspartate:2-oxoglutarate aminotransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
L-aspartate:2-oxoglutarate aminotransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
L-aspartate:2-oxoglutarate aminotransferase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
L-aspartate:2-oxoglutarate aminotransferase activity TAS
Traceable Author Statement
more info
 
L-cysteine:2-oxoglutarate aminotransferase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
carboxylic acid binding IEA
Inferred from Electronic Annotation
more info
 
phosphatidylserine decarboxylase activity IEA
Inferred from Electronic Annotation
more info
 
pyridoxal phosphate binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
2-oxoglutarate metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
 
Notch signaling pathway IEA
Inferred from Electronic Annotation
more info
 
aspartate biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
aspartate catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
aspartate metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
 
cellular amino acid biosynthetic process TAS
Traceable Author Statement
more info
 
cellular response to insulin stimulus IEP
Inferred from Expression Pattern
more info
PubMed 
cellular response to mechanical stimulus IEA
Inferred from Electronic Annotation
more info
 
fatty acid homeostasis IEA
Inferred from Electronic Annotation
more info
 
gluconeogenesis TAS
Traceable Author Statement
more info
 
glutamate catabolic process to 2-oxoglutarate IEA
Inferred from Electronic Annotation
more info
 
glutamate catabolic process to aspartate IEA
Inferred from Electronic Annotation
more info
 
glutamate metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
 
glycerol biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of collagen biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
negative regulation of cytosolic calcium ion concentration IEA
Inferred from Electronic Annotation
more info
 
negative regulation of mitochondrial depolarization IEA
Inferred from Electronic Annotation
more info
 
oxaloacetate metabolic process IEA
Inferred from Electronic Annotation
more info
 
positive regulation of transforming growth factor beta receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
response to cadmium ion IEA
Inferred from Electronic Annotation
more info
 
response to carbohydrate IEA
Inferred from Electronic Annotation
more info
 
response to glucocorticoid IEP
Inferred from Expression Pattern
more info
PubMed 
response to immobilization stress IEA
Inferred from Electronic Annotation
more info
 
response to transition metal nanoparticle IEA
Inferred from Electronic Annotation
more info
 
transdifferentiation IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
axon terminus IEA
Inferred from Electronic Annotation
more info
 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
 
cytosol TAS
Traceable Author Statement
more info
 
extracellular exosome HDA PubMed 
lysosome IEA
Inferred from Electronic Annotation
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleus HDA PubMed 

General protein information

Preferred Names
aspartate aminotransferase, cytoplasmic
Names
aspartate aminotransferase 1
aspartate transaminase 1
cysteine aminotransferase, cytoplasmic
cysteine transaminase, cytoplasmic
glutamate oxaloacetate transaminase 1
glutamic-oxaloacetic transaminase 1, soluble
growth-inhibiting protein 18
testis secretory sperm-binding protein Li 196a
transaminase A
NP_002070.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_032044.1 RefSeqGene

    Range
    5001..38904
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_002079.2NP_002070.1  aspartate aminotransferase, cytoplasmic

    Status: REVIEWED

    Source sequence(s)
    AL391684, DA581933, EB387028
    Consensus CDS
    CCDS7479.1
    UniProtKB/Swiss-Prot
    P17174
    UniProtKB/TrEMBL
    A0A140VK69
    Related
    ENSP00000359539.5, OTTHUMP00000020254, ENST00000370508.6, OTTHUMT00000049794
    Conserved Domains (1) summary
    PTZ00376
    Location:5412
    PTZ00376; aspartate aminotransferase; Provisional

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p12 Primary Assembly

    Range
    99396870..99430773 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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