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GOT1 glutamic-oxaloacetic transaminase 1 [ Homo sapiens (human) ]

Gene ID: 2805, updated on 25-Nov-2021

Summary

Official Symbol
GOT1provided by HGNC
Official Full Name
glutamic-oxaloacetic transaminase 1provided by HGNC
Primary source
HGNC:HGNC:4432
See related
Ensembl:ENSG00000120053 MIM:138180
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
AST1; cCAT; GIG18; cAspAT; ASTQTL1
Summary
Glutamic-oxaloacetic transaminase is a pyridoxal phosphate-dependent enzyme which exists in cytoplasmic and mitochondrial forms, GOT1 and GOT2, respectively. GOT plays a role in amino acid metabolism and the urea and tricarboxylic acid cycles. The two enzymes are homodimeric and show close homology. [provided by RefSeq, Jul 2008]
Expression
Broad expression in heart (RPKM 196.1), liver (RPKM 87.7) and 14 other tissues See more
Orthologs
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Genomic context

See GOT1 in Genome Data Viewer
Location:
10q24.2
Exon count:
9
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 10 NC_000010.11 (99396870..99430624, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (101156627..101190381, complement)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene Sharpr-MPRA regulatory region 10329 Neighboring gene cyclin and CBS domain divalent metal cation transport mediator 1 Neighboring gene uncharacterized LOC107984261 Neighboring gene GOT1 divergent transcript Neighboring gene long intergenic non-protein coding RNA 1475

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
A genome-wide scan of Ashkenazi Jewish Crohn's disease suggests novel susceptibility loci.
GeneReviews: Not available
Aspartate aminotransferase, serum level of, quantitative trait locus 1
MedGen: C3280741 OMIM: 614419 GeneReviews: Not available
Compare labs
Genome-wide association study identifies genetic variants in GOT1 determining serum aspartate aminotransferase levels.
GeneReviews: Not available
Genome-wide association study of liver enzymes in korean children.
GeneReviews: Not available

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables L-aspartate:2-oxoglutarate aminotransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables L-aspartate:2-oxoglutarate aminotransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables L-aspartate:2-oxoglutarate aminotransferase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
enables L-cysteine:2-oxoglutarate aminotransferase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
enables phosphatidylserine decarboxylase activity IEA
Inferred from Electronic Annotation
more info
 
enables pyridoxal phosphate binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in 2-oxoglutarate metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in Notch signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in aspartate biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in aspartate catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in aspartate metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in cellular response to insulin stimulus IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in fatty acid homeostasis IEA
Inferred from Electronic Annotation
more info
 
involved_in glutamate catabolic process to 2-oxoglutarate IEA
Inferred from Electronic Annotation
more info
 
involved_in glutamate catabolic process to aspartate IEA
Inferred from Electronic Annotation
more info
 
involved_in glutamate metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in glycerol biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in oxaloacetate metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in response to glucocorticoid IEP
Inferred from Expression Pattern
more info
PubMed 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in extracellular exosome HDA PubMed 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 
located_in nucleus HDA PubMed 

General protein information

Preferred Names
aspartate aminotransferase, cytoplasmic
Names
aspartate aminotransferase 1
aspartate transaminase 1
cysteine aminotransferase, cytoplasmic
cysteine transaminase, cytoplasmic
glutamate oxaloacetate transaminase 1
glutamic-oxaloacetic transaminase 1, soluble
growth-inhibiting protein 18
testis secretory sperm-binding protein Li 196a
transaminase A
NP_002070.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_032044.1 RefSeqGene

    Range
    5150..38904
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_002079.3NP_002070.1  aspartate aminotransferase, cytoplasmic

    See identical proteins and their annotated locations for NP_002070.1

    Status: REVIEWED

    Source sequence(s)
    AL391684, DA581933, EB387028
    Consensus CDS
    CCDS7479.1
    UniProtKB/Swiss-Prot
    P17174
    UniProtKB/TrEMBL
    A0A140VK69
    Related
    ENSP00000359539.5, ENST00000370508.7
    Conserved Domains (1) summary
    PTZ00376
    Location:5412
    PTZ00376; aspartate aminotransferase; Provisional

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p13 Primary Assembly

    Range
    99396870..99430624 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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