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Gngt2 guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 2 [ Mus musculus (house mouse) ]

Gene ID: 14710, updated on 18-Apr-2019

Summary

Official Symbol
Gngt2provided by MGI
Official Full Name
guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 2provided by MGI
Primary source
MGI:MGI:893584
See related
Ensembl:ENSMUSG00000038811
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
AV096488
Expression
Broad expression in spleen adult (RPKM 5.4), lung adult (RPKM 5.0) and 25 other tissues See more
Orthologs

Genomic context

See Gngt2 in Genome Data Viewer
Location:
11 D; 11 59.01 cM
Exon count:
7
Annotation release Status Assembly Chr Location
106 current GRCm38.p4 (GCF_000001635.24) 11 NC_000077.6 (95842219..95845734)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 11 NC_000077.5 (95703609..95707045)

Chromosome 11 - NC_000077.6Genomic Context describing neighboring genes Neighboring gene predicted gene, 29933 Neighboring gene phosphatase, orphan 1 Neighboring gene predicted gene, 38958 Neighboring gene ABI gene family, member 3 Neighboring gene RIKEN cDNA 4833417C18 gene Neighboring gene predicted gene, 38959 Neighboring gene nuclear encoded tRNA glutamine 6 (anticodon TTG)

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Pathways from BioSystems

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
G-protein beta-subunit binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
GTPase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
signal transduction IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
G-protein beta/gamma-subunit complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
heterotrimeric G-protein complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
membrane IEA
Inferred from Electronic Annotation
more info
 
plasma membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2
Names
G-gamma-8
g gamma-C
guanine nucleotide binding protein (G protein), gamma transducing polypeptide 2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001038664.2NP_001033753.2  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2 precursor

    See identical proteins and their annotated locations for NP_001033753.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) has an alternate 5' UTR exon, compared to variant 3. Variants 1, 2, 3 and 4 encode the same protein.
    Source sequence(s)
    AA028742, BC061005, W35863
    Consensus CDS
    CCDS25284.1
    UniProtKB/Swiss-Prot
    Q61017
    UniProtKB/TrEMBL
    A2A614, Q6P8Y9
    Related
    ENSMUSP00000098101.3, ENSMUST00000100532.9
    Conserved Domains (1) summary
    smart00224
    Location:869
    GGL; G protein gamma subunit-like motifs
  2. NM_001284393.1NP_001271322.1  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2 precursor

    See identical proteins and their annotated locations for NP_001271322.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) represents the longest transcript. Variants 1, 2, 3 and 4 encode the same protein.
    Source sequence(s)
    BC061005, BE847751, BY117112
    Consensus CDS
    CCDS25284.1
    UniProtKB/Swiss-Prot
    Q61017
    UniProtKB/TrEMBL
    A2A614, Q6P8Y9
    Related
    ENSMUSP00000103339.1, ENSMUST00000107711.7
    Conserved Domains (1) summary
    smart00224
    Location:869
    GGL; G protein gamma subunit-like motifs
  3. NM_001284397.1NP_001271326.1  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2 precursor

    See identical proteins and their annotated locations for NP_001271326.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) has an alternate 5' UTR exon and also lacks an internal segment in the 5' UTR, compared to variant 3. variant 3. Variants 1, 2, 3 and 4 encode the same protein.
    Source sequence(s)
    AA423571, AI154009, AI159118, BC061005
    Consensus CDS
    CCDS25284.1
    UniProtKB/Swiss-Prot
    Q61017
    UniProtKB/TrEMBL
    A2A614, Q6P8Y9
    Related
    ENSMUSP00000103337.1, ENSMUST00000107709.7
    Conserved Domains (1) summary
    smart00224
    Location:869
    GGL; G protein gamma subunit-like motifs
  4. NM_023121.2NP_075610.1  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2 precursor

    See identical proteins and their annotated locations for NP_075610.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) lacks an internal segment in the 5' UTR, compared to variant 3. Variants 1, 2, 3 and 4 encode the same protein.
    Source sequence(s)
    AL593858, BE994683, BF470980, BY117112
    Consensus CDS
    CCDS25284.1
    UniProtKB/Swiss-Prot
    Q61017
    UniProtKB/TrEMBL
    A2A614
    Related
    ENSMUSP00000103342.2, ENSMUST00000107714.8
    Conserved Domains (1) summary
    smart00224
    Location:869
    GGL; G protein gamma subunit-like motifs

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p4 C57BL/6J

Genomic

  1. NC_000077.6 Reference GRCm38.p4 C57BL/6J

    Range
    95842219..95845734
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006532231.3XP_006532294.1  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2 isoform X1

    See identical proteins and their annotated locations for XP_006532294.1

    UniProtKB/Swiss-Prot
    Q61017
    UniProtKB/TrEMBL
    A2A614
    Conserved Domains (1) summary
    smart00224
    Location:869
    GGL; G protein gamma subunit-like motifs
  2. XM_011248737.1XP_011247039.1  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2 isoform X1

    See identical proteins and their annotated locations for XP_011247039.1

    UniProtKB/Swiss-Prot
    Q61017
    UniProtKB/TrEMBL
    A2A614
    Related
    ENSMUSP00000103340.1, ENSMUST00000107712.7
    Conserved Domains (1) summary
    smart00224
    Location:869
    GGL; G protein gamma subunit-like motifs
  3. XM_017314274.1XP_017169763.1  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2 isoform X1

    UniProtKB/Swiss-Prot
    Q61017
    UniProtKB/TrEMBL
    A2A614
    Related
    ENSMUSP00000047586.4, ENSMUST00000036088.10
    Conserved Domains (1) summary
    smart00224
    Location:869
    GGL; G protein gamma subunit-like motifs
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