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GNGT2 G protein subunit gamma transducin 2 [ Homo sapiens (human) ]

Gene ID: 2793, updated on 7-Jun-2020

Summary

Official Symbol
GNGT2provided by HGNC
Official Full Name
G protein subunit gamma transducin 2provided by HGNC
Primary source
HGNC:HGNC:4412
See related
Ensembl:ENSG00000167083 MIM:139391
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GNG8; GNG9; GNGT8; G-GAMMA-8; G-GAMMA-C
Summary
Phototransduction in rod and cone photoreceptors is regulated by groups of signaling proteins. The encoded protein is thought to play a crucial role in cone phototransduction. It belongs to the G protein gamma family and localized specifically in cones. Several transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Nov 2010]
Expression
Broad expression in spleen (RPKM 5.8), lymph node (RPKM 4.5) and 21 other tissues See more
Orthologs

Genomic context

See GNGT2 in Genome Data Viewer
Location:
17q21.32
Exon count:
5
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 17 NC_000017.11 (49206234..49210574, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (47283596..47287936, complement)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene beta-1,4-N-acetyl-galactosaminyltransferase 2 Neighboring gene ribosomal protein S10 pseudogene 25 Neighboring gene tRNA-Gln (anticodon TTG) 1-1 Neighboring gene uncharacterized LOC105371816 Neighboring gene ABI family member 3 Neighboring gene phosphoethanolamine/phosphocholine phosphatase 1 Neighboring gene uncharacterized FLJ40194

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Phenotypes

NHGRI GWAS Catalog

Description
Identification of 23 new prostate cancer susceptibility loci using the iCOGS custom genotyping array.
NHGRI GWA Catalog

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
G-protein beta-subunit binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
GTPase activity IDA
Inferred from Direct Assay
more info
PubMed 
GTPase activity NAS
Non-traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
G protein-coupled receptor signaling pathway NAS
Non-traceable Author Statement
more info
PubMed 
phototransduction NAS
Non-traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
G-protein beta/gamma-subunit complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
heterotrimeric G-protein complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
heterotrimeric G-protein complex IDA
Inferred from Direct Assay
more info
PubMed 
heterotrimeric G-protein complex NAS
Non-traceable Author Statement
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2
Names
G protein cone gamma 8 subunit
G-gamma-9
g gamma-C
gamma-T2 subunit
guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 2
guanine nucleotide binding protein gamma 9
guanine nucleotide binding protein gamma transducing activity polypeptide 2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_009841.1 RefSeqGene

    Range
    5001..8148
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001198754.2NP_001185683.1  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2

    See identical proteins and their annotated locations for NP_001185683.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. All four variants encode the same protein.
    Source sequence(s)
    AC069454, BU742490, DA248836
    Consensus CDS
    CCDS11545.1
    UniProtKB/Swiss-Prot
    O14610
    Related
    ENSP00000421710.1, ENST00000507680.6
    Conserved Domains (1) summary
    smart00224
    Location:869
    GGL; G protein gamma subunit-like motifs
  2. NM_001198755.1NP_001185684.1  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2

    See identical proteins and their annotated locations for NP_001185684.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. All four variants encode the same protein.
    Source sequence(s)
    AC069454, AK312839, BU742490
    Consensus CDS
    CCDS11545.1
    UniProtKB/Swiss-Prot
    O14610
    Related
    ENSP00000422879.1, ENST00000511673.1
    Conserved Domains (1) summary
    smart00224
    Location:869
    GGL; G protein gamma subunit-like motifs
  3. NM_001198756.1NP_001185685.1  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2

    See identical proteins and their annotated locations for NP_001185685.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. All four variants encode the same protein.
    Source sequence(s)
    AC069454, BM723861, BU742490
    Consensus CDS
    CCDS11545.1
    UniProtKB/Swiss-Prot
    O14610
    Related
    ENSP00000426022.1, ENST00000511277.5
    Conserved Domains (1) summary
    smart00224
    Location:869
    GGL; G protein gamma subunit-like motifs
  4. NM_031498.2NP_113686.1  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2

    See identical proteins and their annotated locations for NP_113686.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. All four variants encode the same protein.
    Source sequence(s)
    AI857683, BC008663, BU742490
    Consensus CDS
    CCDS11545.1
    UniProtKB/Swiss-Prot
    O14610
    Related
    ENSP00000300406.2, ENST00000300406.6
    Conserved Domains (1) summary
    smart00224
    Location:869
    GGL; G protein gamma subunit-like motifs

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p13 Primary Assembly

    Range
    49206234..49210574 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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