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Gnb1 guanine nucleotide binding protein (G protein), beta 1 [ Mus musculus (house mouse) ]

Gene ID: 14688, updated on 18-Apr-2024

Summary

Official Symbol
Gnb1provided by MGI
Official Full Name
guanine nucleotide binding protein (G protein), beta 1provided by MGI
Primary source
MGI:MGI:95781
See related
Ensembl:ENSMUSG00000029064 AllianceGenome:MGI:95781
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Hg2a; Gnb-1
Summary
Predicted to enable several functions, including GTPase binding activity; alkylglycerophosphoethanolamine phosphodiesterase activity; and spectrin binding activity. Acts upstream of or within several processes, including phospholipase C-activating G protein-coupled receptor signaling pathway; retina development in camera-type eye; and sensory perception of taste. Located in photoreceptor outer segment. Part of heterotrimeric G-protein complex. Is expressed in several structures, including alimentary system; central nervous system; eye; genitourinary system; and hemolymphoid system gland. Human ortholog(s) of this gene implicated in acute lymphoblastic leukemia; autosomal dominant non-syndromic intellectual disability 42; and myelodysplastic syndrome. Orthologous to human GNB1 (G protein subunit beta 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E18 (RPKM 188.2), large intestine adult (RPKM 186.9) and 28 other tissues See more
Orthologs
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Genomic context

Location:
4 E2; 4 86.17 cM
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (155575514..155643726)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (155491300..155559269)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 5830444B04 gene Neighboring gene cilia and flagella associated protein 74 Neighboring gene STARR-positive B cell enhancer ABC_E4738 Neighboring gene STARR-seq mESC enhancer starr_12263 Neighboring gene transmembrane protein 52 Neighboring gene NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 pseudogene Neighboring gene STARR-seq mESC enhancer starr_12266 Neighboring gene STARR-positive B cell enhancer ABC_E340 Neighboring gene STARR-positive B cell enhancer ABC_E10296 Neighboring gene NAD kinase Neighboring gene STARR-positive B cell enhancer ABC_E3559 Neighboring gene solute carrier family 35, member E2 Neighboring gene predicted gene 16023

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 
  • Targeted (1) 
  • Gene trapped (1)  1 citation

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • MGC98074

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables GTPase activity ISO
Inferred from Sequence Orthology
more info
PubMed 
enables GTPase binding ISO
Inferred from Sequence Orthology
more info
 
enables alkylglycerophosphoethanolamine phosphodiesterase activity ISO
Inferred from Sequence Orthology
more info
PubMed 
enables protein-containing complex binding ISO
Inferred from Sequence Orthology
more info
PubMed 
enables signaling receptor complex adaptor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables spectrin binding ISO
Inferred from Sequence Orthology
more info
PubMed 
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within G protein-coupled receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in G protein-coupled receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within G protein-coupled receptor signaling pathway TAS
Traceable Author Statement
more info
PubMed 
acts_upstream_of_or_within cardiac muscle cell apoptotic process ISO
Inferred from Sequence Orthology
more info
PubMed 
acts_upstream_of_or_within cell population proliferation IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within cellular response to hypoxia ISO
Inferred from Sequence Orthology
more info
PubMed 
acts_upstream_of_or_within phospholipase C-activating G protein-coupled receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within phototransduction, visible light ISO
Inferred from Sequence Orthology
more info
PubMed 
involved_in positive regulation of cytosolic calcium ion concentration ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within retina development in camera-type eye IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within sensory perception of taste IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within signal transduction IEA
Inferred from Electronic Annotation
more info
 
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in cell body ISO
Inferred from Sequence Orthology
more info
 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in dendrite ISO
Inferred from Sequence Orthology
more info
 
part_of heterotrimeric G-protein complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of heterotrimeric G-protein complex IPI
Inferred from Physical Interaction
more info
PubMed 
part_of heterotrimeric G-protein complex ISO
Inferred from Sequence Orthology
more info
PubMed 
located_in myelin sheath HDA PubMed 
located_in photoreceptor inner segment ISO
Inferred from Sequence Orthology
more info
 
located_in photoreceptor outer segment IDA
Inferred from Direct Assay
more info
PubMed 
located_in photoreceptor outer segment membrane ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane TAS
Traceable Author Statement
more info
 
is_active_in synapse EXP
Inferred from Experiment
more info
PubMed 
is_active_in synapse IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
Names
guanine nucleotide binding protein, beta 1
heterotrimeric guanine nucleotide-binding protein 2a
transducin beta chain 1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001160016.2NP_001153488.1  guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1

    See identical proteins and their annotated locations for NP_001153488.1

    Status: VALIDATED

    Source sequence(s)
    AL627405, AL670227
    Consensus CDS
    CCDS19030.1
    UniProtKB/Swiss-Prot
    P62874
    UniProtKB/TrEMBL
    Q3TQ70, Q3U1B1
    Related
    ENSMUSP00000030940.8, ENSMUST00000030940.14
    Conserved Domains (2) summary
    cd00200
    Location:48340
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:5895
    7WD40; WD40 repeat [structural motif]
  2. NM_001160017.2NP_001153489.1  guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1

    See identical proteins and their annotated locations for NP_001153489.1

    Status: VALIDATED

    Source sequence(s)
    AL627405, AL670227
    Consensus CDS
    CCDS19030.1
    UniProtKB/Swiss-Prot
    P62874
    UniProtKB/TrEMBL
    Q3TQ70, Q3U1B1
    Related
    ENSMUSP00000101241.4, ENSMUST00000105616.10
    Conserved Domains (2) summary
    cd00200
    Location:48340
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:5895
    7WD40; WD40 repeat [structural motif]
  3. NM_001420967.1NP_001407896.1  guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1

    Status: VALIDATED

    Source sequence(s)
    AL627405, AL670227
    UniProtKB/Swiss-Prot
    P62874
    UniProtKB/TrEMBL
    Q3TQ70
  4. NM_001420968.1NP_001407897.1  guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1

    Status: VALIDATED

    Source sequence(s)
    AL627405, AL670227
    UniProtKB/Swiss-Prot
    P62874
    UniProtKB/TrEMBL
    Q3TQ70
  5. NM_001420969.1NP_001407898.1  guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1

    Status: VALIDATED

    Source sequence(s)
    AL627405, AL670227
    UniProtKB/Swiss-Prot
    P62874
    UniProtKB/TrEMBL
    Q3TQ70
  6. NM_001420970.1NP_001407899.1  guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1

    Status: VALIDATED

    Source sequence(s)
    AL627405, AL670227
    UniProtKB/Swiss-Prot
    P62874
    UniProtKB/TrEMBL
    Q3TQ70
  7. NM_001420971.1NP_001407900.1  guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1

    Status: VALIDATED

    Source sequence(s)
    AL627405, AL670227
    UniProtKB/Swiss-Prot
    P62874
    UniProtKB/TrEMBL
    Q3TQ70
  8. NM_008142.5NP_032168.1  guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1

    See identical proteins and their annotated locations for NP_032168.1

    Status: VALIDATED

    Source sequence(s)
    AL627405, AL670227
    Consensus CDS
    CCDS19030.1
    UniProtKB/Swiss-Prot
    P62874
    UniProtKB/TrEMBL
    Q3TQ70, Q3U1B1
    Related
    ENSMUSP00000130123.2, ENSMUST00000165335.8
    Conserved Domains (2) summary
    cd00200
    Location:48340
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:5895
    7WD40; WD40 repeat [structural motif]

RNA

  1. NR_185220.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL627405, AL670227
  2. NR_185221.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL627405, AL670227
  3. NR_185222.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL627405, AL670227
  4. NR_185223.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL627405, AL670227

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    155575514..155643726
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017319977.2XP_017175466.1  guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 isoform X1

    UniProtKB/Swiss-Prot
    P62874
    UniProtKB/TrEMBL
    Q3TQ70, Q3U1B1
    Related
    ENSMUSP00000135091.2, ENSMUST00000176637.2
    Conserved Domains (2) summary
    cd00200
    Location:48340
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:5895
    7WD40; WD40 repeat [structural motif]