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Gnb1 guanine nucleotide binding protein (G protein), beta 1 [ Mus musculus (house mouse) ]

Gene ID: 14688, updated on 7-Apr-2019

Summary

Official Symbol
Gnb1provided by MGI
Official Full Name
guanine nucleotide binding protein (G protein), beta 1provided by MGI
Primary source
MGI:MGI:95781
See related
Ensembl:ENSMUSG00000029064
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Gnb-1; C77571; AA409223
Expression
Ubiquitous expression in CNS E18 (RPKM 188.2), large intestine adult (RPKM 186.9) and 28 other tissues See more
Orthologs

Genomic context

See Gnb1 in Genome Data Viewer
Location:
4 E2; 4 86.17 cM
Exon count:
12
Annotation release Status Assembly Chr Location
106 current GRCm38.p4 (GCF_000001635.24) 4 NC_000070.6 (155491361..155559269)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 4 NC_000070.5 (154865470..154933378)

Chromosome 4 - NC_000070.6Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 5830444B04 gene Neighboring gene cilia and flagella associated protein 74 Neighboring gene transmembrane protein 52 Neighboring gene NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 pseudogene Neighboring gene NAD kinase Neighboring gene solute carrier family 35, member E2 Neighboring gene predicted gene 16023

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1)  1 citation
  • Endonuclease-mediated (1) 

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC98074

Gene Ontology Provided by MGI

Function Evidence Code Pubs
GTPase activity ISO
Inferred from Sequence Orthology
more info
PubMed 
GTPase binding ISO
Inferred from Sequence Orthology
more info
 
alkylglycerophosphoethanolamine phosphodiesterase activity ISO
Inferred from Sequence Orthology
more info
PubMed 
protein-containing complex binding ISO
Inferred from Sequence Orthology
more info
PubMed 
spectrin binding ISO
Inferred from Sequence Orthology
more info
PubMed 
Process Evidence Code Pubs
G protein-coupled receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
G protein-coupled receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
G protein-coupled receptor signaling pathway TAS
Traceable Author Statement
more info
PubMed 
cardiac muscle cell apoptotic process ISO
Inferred from Sequence Orthology
more info
PubMed 
cell proliferation IDA
Inferred from Direct Assay
more info
PubMed 
cellular response to hypoxia ISO
Inferred from Sequence Orthology
more info
PubMed 
phospholipase C-activating G protein-coupled receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
phototransduction, visible light ISO
Inferred from Sequence Orthology
more info
PubMed 
positive regulation of cytosolic calcium ion concentration ISO
Inferred from Sequence Orthology
more info
 
protein heterotrimerization ISO
Inferred from Sequence Orthology
more info
PubMed 
retina development in camera-type eye IMP
Inferred from Mutant Phenotype
more info
PubMed 
sensory perception of taste IDA
Inferred from Direct Assay
more info
PubMed 
signal transduction IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cell body ISO
Inferred from Sequence Orthology
more info
 
dendrite ISO
Inferred from Sequence Orthology
more info
 
heterotrimeric G-protein complex IPI
Inferred from Physical Interaction
more info
PubMed 
heterotrimeric G-protein complex ISO
Inferred from Sequence Orthology
more info
PubMed 
myelin sheath HDA PubMed 
photoreceptor inner segment ISO
Inferred from Sequence Orthology
more info
 
photoreceptor outer segment IDA
Inferred from Direct Assay
more info
PubMed 
photoreceptor outer segment membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
Names
guanine nucleotide binding protein, beta 1
transducin beta chain 1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001160016.1NP_001153488.1  guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1

    See identical proteins and their annotated locations for NP_001153488.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 3' UTR, compared to variant 1. Variants 1-3 encode the same the protein.
    Source sequence(s)
    AK163844, AL627405, AL670227, U29055
    Consensus CDS
    CCDS19030.1
    UniProtKB/Swiss-Prot
    P62874
    UniProtKB/TrEMBL
    Q3TQ70
    Related
    ENSMUSP00000030940.7, ENSMUST00000030940.13
    Conserved Domains (2) summary
    cd00200
    Location:48340
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:5895
    7WD40; WD40 repeat [structural motif]
  2. NM_001160017.1NP_001153489.1  guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1

    See identical proteins and their annotated locations for NP_001153489.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' and 3' UTRs, compared to variant 1. Variants 1-3 encode the same the protein.
    Source sequence(s)
    AL627405, AL670227, BG807492, U29055
    Consensus CDS
    CCDS19030.1
    UniProtKB/Swiss-Prot
    P62874
    UniProtKB/TrEMBL
    Q3TQ70
    Related
    ENSMUSP00000101241.3, ENSMUST00000105616.9
    Conserved Domains (2) summary
    cd00200
    Location:48340
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:5895
    7WD40; WD40 repeat [structural motif]
  3. NM_008142.4NP_032168.1  guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1

    See identical proteins and their annotated locations for NP_032168.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Variants 1-3 encode the same the protein.
    Source sequence(s)
    AK163844, AL627405, AL670227
    Consensus CDS
    CCDS19030.1
    UniProtKB/Swiss-Prot
    P62874
    UniProtKB/TrEMBL
    Q3TQ70
    Related
    ENSMUSP00000130123.1, ENSMUST00000165335.7
    Conserved Domains (2) summary
    cd00200
    Location:48340
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:5895
    7WD40; WD40 repeat [structural motif]

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p4 C57BL/6J

Genomic

  1. NC_000070.6 Reference GRCm38.p4 C57BL/6J

    Range
    155491361..155559269
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017319977.1XP_017175466.1  guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 isoform X1

    UniProtKB/Swiss-Prot
    P62874
    UniProtKB/TrEMBL
    Q3TQ70
    Related
    ENSMUSP00000135091.1, ENSMUST00000176637.1
    Conserved Domains (2) summary
    cd00200
    Location:48340
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:5895
    7WD40; WD40 repeat [structural motif]
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