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SLC25A10 solute carrier family 25 member 10 [ Homo sapiens (human) ]

Gene ID: 1468, updated on 11-Sep-2019

Summary

Official Symbol
SLC25A10provided by HGNC
Official Full Name
solute carrier family 25 member 10provided by HGNC
Primary source
HGNC:HGNC:10980
See related
Ensembl:ENSG00000183048 MIM:606794
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
DIC
Summary
This gene encodes a member of a family of proteins that translocate small metabolites across the mitochondrial membrane. The encoded protein exchanges dicarboxylates, such as malate and succinate, for phosphate, sulfate, and other small molecules, thereby providing substrates for metabolic processes including the Krebs cycle and fatty acid synthesis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Aug 2012]
Expression
Broad expression in kidney (RPKM 33.1), liver (RPKM 15.3) and 20 other tissues See more
Orthologs

Genomic context

See SLC25A10 in Genome Data Viewer
Location:
17q25.3
Exon count:
12
Annotation release Status Assembly Chr Location
109.20190905 current GRCh38.p13 (GCF_000001405.39) 17 NC_000017.11 (81712236..81721016)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (79679266..79688046)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene hepatocyte growth factor-regulated tyrosine kinase substrate Neighboring gene microRNA 6786 Neighboring gene mitochondrial ribosomal protein L12 Neighboring gene uncharacterized LOC105371929 Neighboring gene uncharacterized LOC105376789 Neighboring gene glucagon receptor

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from BioSystems

  • Degradation of cysteine and homocysteine, organism-specific biosystem (from REACTOME)
    Degradation of cysteine and homocysteine, organism-specific biosystemWhile in humans excess methionine is converted to homocysteine, homocysteine and its transsulfuration product cysteine can be degraded to several end products, two of which, taurine and hydrogen sulf...
  • Gluconeogenesis, organism-specific biosystem (from REACTOME)
    Gluconeogenesis, organism-specific biosystemThe reactions of gluconeogenesis convert mitochondrial pyruvate to cytosolic glucose 6-phosphate which in turn can be hydrolyzed to glucose and exported from the cell. Gluconeogenesis is confined to ...
  • Glucose metabolism, organism-specific biosystem (from REACTOME)
    Glucose metabolism, organism-specific biosystemGlucose is the major form in which dietary sugars are made available to cells of the human body. Its breakdown is a major source of energy for all cells, and is essential for the brain and red blood ...
  • Metabolism, organism-specific biosystem (from REACTOME)
    Metabolism, organism-specific biosystemMetabolic processes in human cells generate energy through the oxidation of molecules consumed in the diet and mediate the synthesis of diverse essential molecules not taken in the diet as well as th...
  • Metabolism of amino acids and derivatives, organism-specific biosystem (from REACTOME)
    Metabolism of amino acids and derivatives, organism-specific biosystemThis group of reactions is responsible for: 1) the breakdown of amino acids; 2) the synthesis of urea from ammonia and amino groups generated by amino acid breakdown; 3) the synthesis of the ten amin...
  • Metabolism of carbohydrates, organism-specific biosystem (from REACTOME)
    Metabolism of carbohydrates, organism-specific biosystemThese pathways together are responsible for: 1) the extraction of energy and carbon skeletons for biosyntheses from dietary sugars and related molecules; 2) the short-term storage of glucose in the b...
  • Organic anion transporters, organism-specific biosystem (from REACTOME)
    Organic anion transporters, organism-specific biosystemThe SLC17 gene family encode proteins which are organic anion transporters. There are three distinct subfamilies within SLC17; vesicular glutamate transporters (VGLUT1-3 encoded by SLC17A7,6 and 8), ...
  • Proximal tubule bicarbonate reclamation, organism-specific biosystem (from KEGG)
    Proximal tubule bicarbonate reclamation, organism-specific biosystemOne of the major tasks of the renal proximal tubule (PT) is to secrete acid into the tubule lumen, thereby reabsorbing approximately 80% of the filtered bicarbonate (HCO3(-)), as well as generating "...
  • Proximal tubule bicarbonate reclamation, conserved biosystem (from KEGG)
    Proximal tubule bicarbonate reclamation, conserved biosystemOne of the major tasks of the renal proximal tubule (PT) is to secrete acid into the tubule lumen, thereby reabsorbing approximately 80% of the filtered bicarbonate (HCO3(-)), as well as generating "...
  • SLC-mediated transmembrane transport, organism-specific biosystem (from REACTOME)
    SLC-mediated transmembrane transport, organism-specific biosystemProteins with transporting functions can be roughly classified into 3 categories: ATP-powered pumps, ion channels, and transporters. Pumps utilize the energy released by ATP hydrolysis to power the m...
  • Sulfide oxidation to sulfate, organism-specific biosystem (from REACTOME)
    Sulfide oxidation to sulfate, organism-specific biosystemWhile the human body is very economical with sulfur amino acids (SAA), superfluous SAA are degraded via cysteine to toxic hydrogen sulfide which must be dealt with. The pathway to oxidize this gas is...
  • Sulfur amino acid metabolism, organism-specific biosystem (from REACTOME)
    Sulfur amino acid metabolism, organism-specific biosystemThe main sulfur amino acids are methionine, cysteine, homocysteine and taurine. Of these, the first two are proteinogenic.This group of reactions contains all processes that 1) break down sulfur amin...
  • Transmembrane transport of small molecules, organism-specific biosystem (from REACTOME)
    Transmembrane transport of small molecules, organism-specific biosystem
    Transmembrane transport of small molecules
  • Transport of inorganic cations/anions and amino acids/oligopeptides, organism-specific biosystem (from REACTOME)
    Transport of inorganic cations/anions and amino acids/oligopeptides, organism-specific biosystemTeleologically, one might argue that inorganic cation and anion transport would be evolutionarily among the oldest transport functions. Eight families comprise the group that transports exclusively i...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
antiporter activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
dicarboxylic acid transmembrane transporter activity TAS
Traceable Author Statement
more info
 
malate transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
oxaloacetate transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
succinate transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
sulfate transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
thiosulfate transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
dicarboxylic acid transport TAS
Traceable Author Statement
more info
PubMed 
gluconeogenesis TAS
Traceable Author Statement
more info
 
ion transport TAS
Traceable Author Statement
more info
 
malate transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mitochondrial transport IEA
Inferred from Electronic Annotation
more info
 
oxaloacetate transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
oxaloacetate(2-) transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
phosphate ion transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
succinate transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
sulfate transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
sulfate transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
sulfide oxidation, using sulfide:quinone oxidoreductase TAS
Traceable Author Statement
more info
 
thiosulfate transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
mitochondrial inner membrane TAS
Traceable Author Statement
more info
 
mitochondrion IDA
Inferred from Direct Assay
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleus HDA PubMed 

General protein information

Preferred Names
mitochondrial dicarboxylate carrier
Names
dicarboxylate ion carrier
solute carrier family 25 (mitochondrial carrier; dicarboxylate transporter), member 10

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001270888.2NP_001257817.1  mitochondrial dicarboxylate carrier isoform 1

    See identical proteins and their annotated locations for NP_001257817.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes isoform 1.
    Source sequence(s)
    AC139530, AI081980, BC015797, HY259124
    Consensus CDS
    CCDS59301.1
    UniProtKB/Swiss-Prot
    Q9UBX3
    UniProtKB/TrEMBL
    A0A0S2Z3G3
    Related
    ENSP00000328403.5, ENST00000331531.9
    Conserved Domains (1) summary
    pfam00153
    Location:95190
    Mito_carr; Mitochondrial carrier protein
  2. NM_001270953.1NP_001257882.1  mitochondrial dicarboxylate carrier isoform 3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) uses an alternate splice site in the coding region, which results in a frameshift, compared to variant 1. The encoded isoform (3) has a distinct C-terminus and is longer than isoform 1.
    Source sequence(s)
    AC139530, AI081980, BC007355, BM561945, HY259124
    Consensus CDS
    CCDS74176.1
    UniProtKB/Swiss-Prot
    Q9UBX3
    UniProtKB/TrEMBL
    F6RGN5
    Related
    ENSP00000446242.2, ENST00000545862.5
    Conserved Domains (1) summary
    pfam00153
    Location:1393
    Mito_carr; Mitochondrial carrier protein
  3. NM_012140.5NP_036272.2  mitochondrial dicarboxylate carrier isoform 2

    See identical proteins and their annotated locations for NP_036272.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the coding region, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
    Source sequence(s)
    AC139530, AI081980, BC007355, HY259124
    Consensus CDS
    CCDS11786.1
    UniProtKB/Swiss-Prot
    Q9UBX3
    UniProtKB/TrEMBL
    A0A0S2Z382
    Related
    ENSP00000345580.5, ENST00000350690.10
    Conserved Domains (1) summary
    pfam00153
    Location:198284
    Mito_carr; Mitochondrial carrier protein

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p13 Primary Assembly

    Range
    81712236..81721016
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017024220.1XP_016879709.1  mitochondrial dicarboxylate carrier isoform X1

    UniProtKB/TrEMBL
    B4E1E9
    Conserved Domains (1) summary
    pfam00153
    Location:155241
    Mito_carr; Mitochondrial carrier protein
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