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SLC25A10 solute carrier family 25 member 10 [ Homo sapiens (human) ]

Gene ID: 1468, updated on 7-Jun-2020

Summary

Official Symbol
SLC25A10provided by HGNC
Official Full Name
solute carrier family 25 member 10provided by HGNC
Primary source
HGNC:HGNC:10980
See related
Ensembl:ENSG00000183048 MIM:606794
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
DIC
Summary
This gene encodes a member of a family of proteins that translocate small metabolites across the mitochondrial membrane. The encoded protein exchanges dicarboxylates, such as malate and succinate, for phosphate, sulfate, and other small molecules, thereby providing substrates for metabolic processes including the Krebs cycle and fatty acid synthesis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Aug 2012]
Expression
Broad expression in kidney (RPKM 33.1), liver (RPKM 15.3) and 20 other tissues See more
Orthologs

Genomic context

See SLC25A10 in Genome Data Viewer
Location:
17q25.3
Exon count:
12
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 17 NC_000017.11 (81712236..81721016)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (79679266..79688046)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene hepatocyte growth factor-regulated tyrosine kinase substrate Neighboring gene microRNA 6786 Neighboring gene mitochondrial ribosomal protein L12 Neighboring gene uncharacterized LOC105371929 Neighboring gene uncharacterized LOC105376789 Neighboring gene glucagon receptor

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
antiporter activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
dicarboxylic acid transmembrane transporter activity TAS
Traceable Author Statement
more info
 
malate transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
oxaloacetate transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
succinate transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
sulfate transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
thiosulfate transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
dicarboxylic acid transport TAS
Traceable Author Statement
more info
 
gluconeogenesis TAS
Traceable Author Statement
more info
 
ion transport TAS
Traceable Author Statement
more info
 
malate transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mitochondrial transport IEA
Inferred from Electronic Annotation
more info
 
oxaloacetate transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
oxaloacetate(2-) transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
phosphate ion transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
succinate transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
sulfate transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
sulfate transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
sulfide oxidation, using sulfide:quinone oxidoreductase TAS
Traceable Author Statement
more info
 
thiosulfate transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
mitochondrial inner membrane TAS
Traceable Author Statement
more info
 
mitochondrion IDA
Inferred from Direct Assay
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleus HDA PubMed 

General protein information

Preferred Names
mitochondrial dicarboxylate carrier
Names
dicarboxylate ion carrier
solute carrier family 25 (mitochondrial carrier; dicarboxylate transporter), member 10

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001270888.2NP_001257817.1  mitochondrial dicarboxylate carrier isoform 1

    See identical proteins and their annotated locations for NP_001257817.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes isoform 1.
    Source sequence(s)
    AC139530, AI081980, BC015797, HY259124
    Consensus CDS
    CCDS59301.1
    UniProtKB/Swiss-Prot
    Q9UBX3
    UniProtKB/TrEMBL
    A0A0S2Z3G3
    Related
    ENSP00000328403.5, ENST00000331531.9
    Conserved Domains (1) summary
    pfam00153
    Location:95190
    Mito_carr; Mitochondrial carrier protein
  2. NM_001270953.1NP_001257882.1  mitochondrial dicarboxylate carrier isoform 3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) uses an alternate splice site in the coding region, which results in a frameshift, compared to variant 1. The encoded isoform (3) has a distinct C-terminus and is longer than isoform 1.
    Source sequence(s)
    AC139530, AI081980, BC007355, BM561945, HY259124
    Consensus CDS
    CCDS74176.1
    UniProtKB/Swiss-Prot
    Q9UBX3
    UniProtKB/TrEMBL
    F6RGN5
    Related
    ENSP00000446242.2, ENST00000545862.5
    Conserved Domains (1) summary
    pfam00153
    Location:1393
    Mito_carr; Mitochondrial carrier protein
  3. NM_012140.5NP_036272.2  mitochondrial dicarboxylate carrier isoform 2

    See identical proteins and their annotated locations for NP_036272.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the coding region, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
    Source sequence(s)
    AC139530, AI081980, BC007355, HY259124
    Consensus CDS
    CCDS11786.1
    UniProtKB/Swiss-Prot
    Q9UBX3
    UniProtKB/TrEMBL
    A0A0S2Z382
    Related
    ENSP00000345580.5, ENST00000350690.10
    Conserved Domains (1) summary
    pfam00153
    Location:198284
    Mito_carr; Mitochondrial carrier protein

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p13 Primary Assembly

    Range
    81712236..81721016
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017024220.1XP_016879709.1  mitochondrial dicarboxylate carrier isoform X1

    UniProtKB/TrEMBL
    B4E1E9
    Conserved Domains (1) summary
    pfam00153
    Location:155241
    Mito_carr; Mitochondrial carrier protein
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