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Gnai3 G protein subunit alpha i3 [ Mus musculus (house mouse) ]

Gene ID: 14679, updated on 8-Feb-2024

Summary

Official Symbol
Gnai3provided by MGI
Official Full Name
G protein subunit alpha i3provided by MGI
Primary source
MGI:MGI:95773
See related
Ensembl:ENSMUSG00000000001 AllianceGenome:MGI:95773
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Hg1a; Gnai-3; Galphai3
Summary
Predicted to enable several functions, including G-protein beta/gamma-subunit complex binding activity; GDP binding activity; and GTPase activating protein binding activity. Predicted to be involved in several processes, including positive regulation of NAD(P)H oxidase activity; positive regulation of superoxide anion generation; and positive regulation of vascular associated smooth muscle cell proliferation. Predicted to act upstream of or within G protein-coupled receptor signaling pathway. Located in Golgi apparatus. Is expressed in early conceptus; inner ear; and oocyte. Orthologous to human GNAI3 (G protein subunit alpha i3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in placenta adult (RPKM 67.1), CNS E11.5 (RPKM 42.8) and 26 other tissues See more
Orthologs
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Genomic context

See Gnai3 in Genome Data Viewer
Location:
3 F2.3; 3 46.83 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (108014591..108053468, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (108107275..108146152, complement)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene adenosine monophosphate deaminase 2 Neighboring gene predicted gene 12500 Neighboring gene G protein subunit alpha transducin 2 Neighboring gene STARR-positive B cell enhancer ABC_E2092 Neighboring gene STARR-positive B cell enhancer ABC_E2093 Neighboring gene G protein-coupled receptor 61 Neighboring gene predicted gene, 40122

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables G protein-coupled receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables G protein-coupled serotonin receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables G-protein beta/gamma-subunit complex binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables G-protein beta/gamma-subunit complex binding IEA
Inferred from Electronic Annotation
more info
 
enables GDP binding ISO
Inferred from Sequence Orthology
more info
 
enables GTP binding IEA
Inferred from Electronic Annotation
more info
 
enables GTPase activating protein binding ISO
Inferred from Sequence Orthology
more info
 
enables GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables GTPase activity ISO
Inferred from Sequence Orthology
more info
 
enables GTPase activity TAS
Traceable Author Statement
more info
PubMed 
enables guanyl nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein domain specific binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within G protein-coupled receptor signaling pathway TAS
Traceable Author Statement
more info
PubMed 
involved_in GTP metabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in adenylate cyclase-modulating G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in adenylate cyclase-modulating G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within cell cycle IEA
Inferred from Electronic Annotation
more info
 
involved_in cell division ISO
Inferred from Sequence Orthology
more info
 
involved_in dopamine receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in dopamine receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of apoptotic signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of macroautophagy ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of superoxide anion generation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of vascular associated smooth muscle cell proliferation ISO
Inferred from Sequence Orthology
more info
 
NOT acts_upstream_of_or_within regulation of heart contraction IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within signal transduction IEA
Inferred from Electronic Annotation
more info
 
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
 
involved_in vesicle fusion ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in Golgi apparatus IDA
Inferred from Direct Assay
more info
PubMed 
colocalizes_with Golgi membrane ISO
Inferred from Sequence Orthology
more info
 
located_in centrosome ISO
Inferred from Sequence Orthology
more info
 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
colocalizes_with endoplasmic reticulum membrane ISO
Inferred from Sequence Orthology
more info
 
part_of heterotrimeric G-protein complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of heterotrimeric G-protein complex TAS
Traceable Author Statement
more info
PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in midbody ISO
Inferred from Sequence Orthology
more info
 
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane TAS
Traceable Author Statement
more info
 
located_in zymogen granule ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
guanine nucleotide-binding protein G(i) subunit alpha-3
Names
g(i) alpha-3
guanine nucleotide binding protein (G protein), alpha inhibiting 3
guanine nucleotide binding protein, alpha inhibiting 3
guanine nucleotide-binding protein G(i) subunit alpha
guanine nucleotide-binding protein G(k) subunit alpha
heterotrimeric guanine nucleotide-binding protein 1a

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_010306.3NP_034436.1  guanine nucleotide-binding protein G(i) subunit alpha-3

    See identical proteins and their annotated locations for NP_034436.1

    Status: VALIDATED

    Source sequence(s)
    AK169285, BP765831, BY126665
    Consensus CDS
    CCDS17751.1
    UniProtKB/Swiss-Prot
    A2AE36, Q3TGV1, Q61019, Q9DC51
    UniProtKB/TrEMBL
    Q3TJH1
    Related
    ENSMUSP00000000001.5, ENSMUST00000000001.5
    Conserved Domains (1) summary
    cd00066
    Location:34348
    G-alpha; Alpha subunit of G proteins (guanine nucleotide binding)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    108014591..108053468 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)