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Gnai2 G protein subunit alpha i2 [ Mus musculus (house mouse) ]

Gene ID: 14678, updated on 8-Feb-2024

Summary

Official Symbol
Gnai2provided by MGI
Official Full Name
G protein subunit alpha i2provided by MGI
Primary source
MGI:MGI:95772
See related
Ensembl:ENSMUSG00000032562 AllianceGenome:MGI:95772
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Gia; Hg1c; Gnai-2; Galphai2
Summary
Predicted to enable several functions, including G-protein beta/gamma-subunit complex binding activity; GTP binding activity; and GTPase activity. Acts upstream of or within G protein-coupled acetylcholine receptor signaling pathway; adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway; and cell population proliferation. Located in cell body and dendrite. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Used to study inflammatory bowel disease 12. Orthologous to human GNAI2 (G protein subunit alpha i2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in lung adult (RPKM 259.7), thymus adult (RPKM 238.6) and 28 other tissues See more
Orthologs
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Genomic context

See Gnai2 in Genome Data Viewer
Location:
9 F1; 9 58.43 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (107491324..107512542, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (107614125..107635391, complement)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene interferon-related developmental regulator 2 Neighboring gene leucine-rich single-pass membrane protein 2 Neighboring gene STARR-positive B cell enhancer ABC_E11753 Neighboring gene sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B Neighboring gene STARR-positive B cell enhancer ABC_E8314 Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:107527067-107527220 Neighboring gene STARR-seq mESC enhancer starr_25181 Neighboring gene predicted gene, 53518 Neighboring gene STARR-seq mESC enhancer starr_25182 Neighboring gene STARR-positive B cell enhancer ABC_E5103 Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:107546963-107547072 Neighboring gene STARR-positive B cell enhancer ABC_E8315 Neighboring gene solute carrier family 38, member 3 Neighboring gene G protein subunit alpha transducin 1

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables G protein-coupled receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables G-protein beta/gamma-subunit complex binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables G-protein beta/gamma-subunit complex binding IEA
Inferred from Electronic Annotation
more info
 
enables GTP binding ISA
Inferred from Sequence Alignment
more info
PubMed 
enables GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables GTPase activity IEA
Inferred from Electronic Annotation
more info
 
enables guanyl nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within G protein-coupled acetylcholine receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in G protein-coupled adenosine receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in G protein-coupled adenosine receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in G protein-coupled receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway ISA
Inferred from Sequence Alignment
more info
PubMed 
involved_in adenylate cyclase-modulating G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within cell cycle IEA
Inferred from Electronic Annotation
more info
 
involved_in cell division ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within cell population proliferation IPI
Inferred from Physical Interaction
more info
PubMed 
involved_in gamma-aminobutyric acid signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in gamma-aminobutyric acid signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of adenylate cyclase-activating adrenergic receptor signaling pathway involved in heart process ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of apoptotic signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of calcium ion-dependent exocytosis ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of synaptic transmission ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of ERK1 and ERK2 cascade ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cell migration ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of insulin receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of neural precursor cell proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of superoxide anion generation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of urine volume ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of vascular associated smooth muscle cell proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of calcium ion transport ISO
Inferred from Sequence Orthology
more info
 
NOT acts_upstream_of_or_within regulation of heart contraction IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within signal transduction IEA
Inferred from Electronic Annotation
more info
 
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in cell body IDA
Inferred from Direct Assay
more info
PubMed 
located_in centrosome ISO
Inferred from Sequence Orthology
more info
 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in dendrite IDA
Inferred from Direct Assay
more info
PubMed 
part_of heterotrimeric G-protein complex IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in midbody ISO
Inferred from Sequence Orthology
more info
 
is_active_in neuronal dense core vesicle EXP
Inferred from Experiment
more info
PubMed 
is_active_in neuronal dense core vesicle IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
guanine nucleotide-binding protein G(i) subunit alpha-2
Names
adenylate cyclase-inhibiting G alpha protein
guanine nucleotide binding protein (G protein), alpha inhibiting 2
heterotrimeric guanine nucleotide-binding protein 1c

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001410185.1NP_001397114.1  guanine nucleotide-binding protein G(i) subunit alpha-2

    Status: VALIDATED

    Source sequence(s)
    AC162905, AL672219
    UniProtKB/Swiss-Prot
    P08752, Q3TXK7, Q6P1C0
    Related
    ENSMUSP00000142326.2, ENSMUST00000192615.6
  2. NM_008138.5NP_032164.2  guanine nucleotide-binding protein G(i) subunit alpha-2

    See identical proteins and their annotated locations for NP_032164.2

    Status: VALIDATED

    Source sequence(s)
    AK167388, CF951009, CJ134826
    Consensus CDS
    CCDS23502.1
    UniProtKB/Swiss-Prot
    P08752, Q3TXK7, Q6P1C0
    Related
    ENSMUSP00000057543.7, ENSMUST00000055704.12
    Conserved Domains (1) summary
    cd00066
    Location:34349
    G-alpha; Alpha subunit of G proteins (guanine nucleotide binding)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    107491324..107512542 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)