U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Gnai1 G protein subunit alpha i1 [ Mus musculus (house mouse) ]

Gene ID: 14677, updated on 23-Nov-2023

Summary

Official Symbol
Gnai1provided by MGI
Official Full Name
G protein subunit alpha i1provided by MGI
Primary source
MGI:MGI:95771
See related
Ensembl:ENSMUSG00000057614 AllianceGenome:MGI:95771
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Hg1b; Gnai-1; Gialpha1
Summary
Predicted to enable several functions, including G-protein beta/gamma-subunit complex binding activity; GTPase activating protein binding activity; and guanyl ribonucleotide binding activity. Predicted to be involved in several processes, including cellular response to forskolin; positive regulation of protein localization to cell cortex; and regulation of mitotic spindle organization. Predicted to act upstream of or within signal transduction. Predicted to be located in several cellular components, including centrosome; membrane raft; and midbody. Predicted to be part of heterotrimeric G-protein complex. Is expressed in several structures, including Grueneberg ganglion; forelimb; gonad; gut; and nervous system. Orthologous to human GNAI1 (G protein subunit alpha i1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in frontal lobe adult (RPKM 36.7), cerebellum adult (RPKM 28.5) and 17 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See Gnai1 in Genome Data Viewer
Location:
5 A3; 5 8.16 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2023_04 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (18470133..18565411, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (18265135..18360413, complement)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 31612 Neighboring gene G protein subunit alpha transducin 3 Neighboring gene predicted gene, 54321 Neighboring gene predicted gene 3527 Neighboring gene predicted gene, 31752 Neighboring gene transketolase pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (5)  1 citation
  • Endonuclease-mediated (2) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables D2 dopamine receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables G protein-coupled receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables G protein-coupled serotonin receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables G protein-coupled serotonin receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables G-protein beta/gamma-subunit complex binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables GDP binding ISO
Inferred from Sequence Orthology
more info
 
enables GTP binding ISO
Inferred from Sequence Orthology
more info
 
enables GTPase activating protein binding ISO
Inferred from Sequence Orthology
more info
 
enables GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables GTPase activity ISO
Inferred from Sequence Orthology
more info
 
enables GTPase activity TAS
Traceable Author Statement
more info
PubMed 
enables guanyl nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables magnesium ion binding ISO
Inferred from Sequence Orthology
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
located_in cell cortex ISO
Inferred from Sequence Orthology
more info
 
located_in cell cortex region ISO
Inferred from Sequence Orthology
more info
 
located_in centrosome ISO
Inferred from Sequence Orthology
more info
 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
part_of heterotrimeric G-protein complex IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in intracellular anatomical structure IDA
Inferred from Direct Assay
more info
PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in midbody ISO
Inferred from Sequence Orthology
more info
 
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane TAS
Traceable Author Statement
more info
 
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
guanine nucleotide-binding protein G(i) subunit alpha-1
Names
adenylate cyclase-inhibiting G alpha protein
guanine nucleotide binding protein (G protein), alpha inhibiting 1
guanine nucleotide binding protein, alpha inhibiting 1
heterotrimeric guanine nucleotide-binding protein 1b

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_010305.1NP_034435.1  guanine nucleotide-binding protein G(i) subunit alpha-1

    See identical proteins and their annotated locations for NP_034435.1

    Status: VALIDATED

    Source sequence(s)
    AC116505, BC032995, BY740128
    Consensus CDS
    CCDS39018.1
    UniProtKB/Swiss-Prot
    B2RSH2
    UniProtKB/TrEMBL
    Q3TJH1
    Related
    ENSMUSP00000074259.6, ENSMUST00000074694.7
    Conserved Domains (1) summary
    cd00066
    Location:34348
    G-alpha; Alpha subunit of G proteins (guanine nucleotide binding)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2023_04

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    18470133..18565411 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)