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GNAI1 G protein subunit alpha i1 [ Homo sapiens (human) ]

Gene ID: 2770, updated on 29-Mar-2021

Summary

Official Symbol
GNAI1provided by HGNC
Official Full Name
G protein subunit alpha i1provided by HGNC
Primary source
HGNC:HGNC:4384
See related
Ensembl:ENSG00000127955 MIM:139310
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
Gi
Summary
Guanine nucleotide binding proteins are heterotrimeric signal-transducing molecules consisting of alpha, beta, and gamma subunits. The alpha subunit binds guanine nucleotide, can hydrolyze GTP, and can interact with other proteins. The protein encoded by this gene represents the alpha subunit of an inhibitory complex. The encoded protein is part of a complex that responds to beta-adrenergic signals by inhibiting adenylate cyclase. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]
Expression
Ubiquitous expression in fat (RPKM 39.3), brain (RPKM 28.1) and 22 other tissues See more
Orthologs
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Genomic context

See GNAI1 in Genome Data Viewer
Location:
7q21.11
Exon count:
9
Annotation release Status Assembly Chr Location
109.20210226 current GRCh38.p13 (GCF_000001405.39) 7 NC_000007.14 (80134831..80226181)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (79764147..79855497)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105375372 Neighboring gene ribosomal protein L10 pseudogene 11 Neighboring gene uncharacterized LOC107986743 Neighboring gene RNA, 7SL, cytoplasmic 869, pseudogene Neighboring gene uncharacterized LOC107986744

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env HIV-1 gp120-mediated phosphorylation of WAVE2 requires both G(alpha)i-dependent and -independent pathways, and is conserved both in X4 and R5 viral infection of resting CD4 T cells and primary macrophages PubMed
env HIV-1 gp120 induces IL-1beta release from macrophages in a time- and concentration-dependent manner through binding to the chemokine receptor CCR5 and coupling to G(i)alpha protein PubMed
env CXCR4-tropic and CXCR4/CCR5 dual-tropic HIV-1 gp120 induce the cleavage of CD62 ligand by a mechanism dependent on matrix metalloproteinases 1 and 3, CD4, CXCR4, Galpha(i), and p38 MAPK, whereas CCR5-tropic gp120 does not PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
G protein-coupled receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
G protein-coupled receptor binding ISS
Inferred from Sequence or Structural Similarity
more info
 
G protein-coupled serotonin receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
G-protein beta/gamma-subunit complex binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
GDP binding ISS
Inferred from Sequence or Structural Similarity
more info
 
GTP binding ISS
Inferred from Sequence or Structural Similarity
more info
 
GTPase activating protein binding IEA
Inferred from Electronic Annotation
more info
 
GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
GTPase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
GTPase activity TAS
Traceable Author Statement
more info
 
magnesium ion binding ISS
Inferred from Sequence or Structural Similarity
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
G protein-coupled receptor signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
G protein-coupled receptor signaling pathway TAS
Traceable Author Statement
more info
 
adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway TAS
Traceable Author Statement
more info
 
adenylate cyclase-modulating G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cell cycle IEA
Inferred from Electronic Annotation
more info
 
cell division IMP
Inferred from Mutant Phenotype
more info
PubMed 
cellular response to forskolin ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of synaptic transmission IEA
Inferred from Electronic Annotation
more info
 
positive regulation of protein localization to cell cortex IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein folding TAS
Traceable Author Statement
more info
 
regulation of cAMP-mediated signaling ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of mitotic spindle organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
response to peptide hormone ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
cell cortex region IDA
Inferred from Direct Assay
more info
PubMed 
centrosome IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
extracellular exosome HDA PubMed 
heterotrimeric G-protein complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
lysosomal membrane HDA PubMed 
membrane raft IEA
Inferred from Electronic Annotation
more info
 
midbody IDA
Inferred from Direct Assay
more info
PubMed 
nucleus IEA
Inferred from Electronic Annotation
more info
 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
guanine nucleotide-binding protein G(i) subunit alpha-1
Names
Gi1 protein alpha subunit
adenylate cyclase-inhibiting G alpha protein
guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001256414.2NP_001243343.1  guanine nucleotide-binding protein G(i) subunit alpha-1 isoform 2

    See identical proteins and their annotated locations for NP_001243343.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (2) is shorter at the N-terminus compared to isoform 1.
    Source sequence(s)
    AC080066, AK304442, BC026326
    Consensus CDS
    CCDS59061.1
    UniProtKB/Swiss-Prot
    P63096
    Related
    ENSP00000410572.2, ENST00000457358.7
    Conserved Domains (1) summary
    cd00066
    Location:1296
    G-alpha; Alpha subunit of G proteins (guanine nucleotide binding)
  2. NM_002069.6NP_002060.4  guanine nucleotide-binding protein G(i) subunit alpha-1 isoform 1

    See identical proteins and their annotated locations for NP_002060.4

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC004159, AC080066
    Consensus CDS
    CCDS5595.1
    UniProtKB/Swiss-Prot
    P63096
    Related
    ENSP00000497260.1, ENST00000649796.2
    Conserved Domains (1) summary
    cd00066
    Location:34348
    G-alpha; Alpha subunit of G proteins (guanine nucleotide binding)

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210226

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p13 Primary Assembly

    Range
    80134831..80226181
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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