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CSRP2 cysteine and glycine rich protein 2 [ Homo sapiens (human) ]

Gene ID: 1466, updated on 3-Jun-2018
Official Symbol
CSRP2provided by HGNC
Official Full Name
cysteine and glycine rich protein 2provided by HGNC
Primary source
HGNC:HGNC:2470
See related
Ensembl:ENSG00000175183 MIM:601871; Vega:OTTHUMG00000169919
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CRP2; LMO5; SmLIM
Summary
CSRP2 is a member of the CSRP family of genes, encoding a group of LIM domain proteins, which may be involved in regulatory processes important for development and cellular differentiation. CRP2 contains two copies of the cysteine-rich amino acid sequence motif (LIM) with putative zinc-binding activity, and may be involved in regulating ordered cell growth. Other genes in the family include CSRP1 and CSRP3. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]
Expression
Ubiquitous expression in esophagus (RPKM 37.2), placenta (RPKM 35.3) and 23 other tissues See more
Orthologs
See CSRP2 in Genome Data Viewer
Location:
12q21.2
Exon count:
6
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 12 NC_000012.12 (76858715..76879040, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (77252495..77272814, complement)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene RWD domain containing 1 pseudogene 3 Neighboring gene zinc finger DHHC-type containing 17 Neighboring gene RAN binding protein 1 pseudogene Neighboring gene E2F transcription factor 7

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
molecular_function ND
No biological Data available
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
cell differentiation NAS
Non-traceable Author Statement
more info
PubMed 
multicellular organism development IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
focal adhesion HDA PubMed 
nucleus NAS
Non-traceable Author Statement
more info
PubMed 
Preferred Names
cysteine and glycine-rich protein 2
Names
LIM domain only 5, smooth muscle
LIM domain only protein 5
LMO-5
cysteine-rich protein 2
smooth muscle cell LIM protein

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001300965.1NP_001287894.1  cysteine and glycine-rich protein 2

    See identical proteins and their annotated locations for NP_001287894.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC124784, BC000992, BX461295, CN408330
    Consensus CDS
    CCDS9015.1
    UniProtKB/Swiss-Prot
    Q16527
    UniProtKB/TrEMBL
    A0A024RBB5
    Related
    ENSP00000450056.1, OTTHUMP00000242478, ENST00000546966.5, OTTHUMT00000406575
    Conserved Domains (2) summary
    cd09480
    Location:963
    LIM1_CRP2; The first LIM domain of Cysteine Rich Protein 2 (CRP2)
    cd09840
    Location:119172
    LIM2_CRP2; The second LIM domain of Cysteine Rich Protein 2 (CRP2)
  2. NM_001321.2NP_001312.1  cysteine and glycine-rich protein 2

    See identical proteins and their annotated locations for NP_001312.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC124784, BC000992, BX461295
    Consensus CDS
    CCDS9015.1
    UniProtKB/Swiss-Prot
    Q16527
    UniProtKB/TrEMBL
    A0A024RBB5
    Related
    ENSP00000310901.5, OTTHUMP00000242476, ENST00000311083.9, OTTHUMT00000406572
    Conserved Domains (2) summary
    cd09480
    Location:963
    LIM1_CRP2; The first LIM domain of Cysteine Rich Protein 2 (CRP2)
    cd09840
    Location:119172
    LIM2_CRP2; The second LIM domain of Cysteine Rich Protein 2 (CRP2)

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p12 Primary Assembly

    Range
    76858715..76879040 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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