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Csrp2 cysteine and glycine-rich protein 2 [ Mus musculus (house mouse) ]

Gene ID: 13008, updated on 18-Sep-2024

Summary

Official Symbol
Csrp2provided by MGI
Official Full Name
cysteine and glycine-rich protein 2provided by MGI
Primary source
MGI:MGI:1202907
See related
Ensembl:ENSMUSG00000020186 AllianceGenome:MGI:1202907
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Crp2; SmLim
Summary
Predicted to enable actinin binding activity. Predicted to be a structural constituent of muscle. Predicted to be involved in muscle tissue development and sarcomere organization. Predicted to act upstream of or within cell differentiation. Predicted to be active in Z disc and nucleus. Is expressed in several structures, including cardiovascular system; central nervous system; cranium; genitourinary system; and gut. Orthologous to human CSRP2 (cysteine and glycine rich protein 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in bladder adult (RPKM 126.9), CNS E11.5 (RPKM 76.3) and 22 other tissues See more
Orthologs
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Genomic context

See Csrp2 in Genome Data Viewer
Location:
10 D1; 10 57.84 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (110756037..110775375)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (110920176..110939514)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 1700020G17 gene Neighboring gene predicted gene, 22186 Neighboring gene predicted gene, 22236 Neighboring gene zinc finger, DHHC domain containing 17 Neighboring gene STARR-positive B cell enhancer ABC_E9351 Neighboring gene predicted gene, 51781

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Targeted (2)  1 citation

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables actinin binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables structural constituent of muscle IBA
Inferred from Biological aspect of Ancestor
more info
 
Process Evidence Code Pubs
involved_in cell differentiation IEA
Inferred from Electronic Annotation
more info
 
involved_in muscle tissue development IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in sarcomere organization IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
is_active_in Z disc IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
cysteine and glycine-rich protein 2
Names
DLP-1
cysteine-rich protein 2
double LIM protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_007792.4NP_031818.3  cysteine and glycine-rich protein 2

    See identical proteins and their annotated locations for NP_031818.3

    Status: VALIDATED

    Source sequence(s)
    AK012647, BY333413, CK031156
    Consensus CDS
    CCDS24165.1
    UniProtKB/Swiss-Prot
    P97314, Q9CZG5
    UniProtKB/TrEMBL
    Q71V27, Q9D1M8
    Related
    ENSMUSP00000020403.6, ENSMUST00000020403.7
    Conserved Domains (2) summary
    cd09480
    Location:963
    LIM1_CRP2; The first LIM domain of Cysteine Rich Protein 2 (CRP2)
    cd09840
    Location:119172
    LIM2_CRP2; The second LIM domain of Cysteine Rich Protein 2 (CRP2)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    110756037..110775375
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)